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Catch up with the recent Portrait webinar series with your host Dr Gorkem Hamali. Gorkem is chatting with Dr Kevin Fernando who discusses the practicalities and pitfalls of GLP-1 RA's in type 2 diabetes and obesity.

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Is The Keto Diet Good For Fibromyalgia? In this informative video, we will discuss the ketogenic diet and its potential role in managing fibromyalgia symptoms. Fibromyalgia is a complex condition characterized by widespread pain, fatigue, and a variety of neurological issues. Many individuals living with fibromyalgia often seek alternative methods to alleviate their symptoms, including dietary changes. The ketogenic diet, known for its low-carb and high-fat approach, may offer some benefits for those affected by this condition. By shifting the body into a state of ketosis, this diet utilizes fat for energy instead of carbohydrates, which could impact inflammation, oxidative stress, and energy levels. We will explore how these factors relate to fibromyalgia and the possible advantages of incorporating this diet into a treatment plan. We will also highlight the importance of consulting with healthcare professionals before making any significant dietary changes, especially for individuals on medications. Additionally, we will provide practical tips for implementing the ketogenic diet safely and effectively. Join us as we navigate the potential benefits of the ketogenic diet for fibromyalgia management and share strategies for integrating it into your current treatment plan. Don’t forget to subscribe for more helpful discussions on health and wellness topics. ⬇️ Subscribe to our channel for more valuable insights. 🔗Subscribe: https://www.youtube.com/@Pharmaceutical-Insights/?sub_confirmation=1 #KetoDiet #Fibromyalgia #ChronicPain #HealthTips #Nutrition #DietaryChanges #PainManagement #Ketosis #Fatigue #Wellness #ChronicIllness #EnergyLevels #Neurotransmitters #Inflammation #HealthyLiving #DietAndHealth About Us: Welcome to Pharmaceutical Insights! Our channel is dedicated to providing clear and informative content on a variety of topics related to pharmaceutical drugs, prescription medications, over-the-counter medicines, drug side effects, and medication safety. We also discuss medical treatments, alternative medicine, and pain management drugs, ensuring you have access to the information you need to make informed health decisions. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

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Interventions like ketogenic metabolic therapy (aka ketogenic diet) are being used to treat serious mental illnesses like major depression, bipolar and schizophrenia. Georgia Ede, MD is a pioneer in Metabolic Psychiatry, and has used a ketogenic diet to help hundreds of patients improve their symptoms of mental illess. Dr. Georgia Ede is a Harvard-trained psychiatrist and worldwide expert in nutritional psychiatry. Dr. Ede has over a decade of real-world experience using nutrition as a treatment for mental illness. In her talk, she describes her real-world experience using ketogenic metabolic interventions to restore brain function in psychiatric disorders. Bio: https://www.diagnosisdiet.com/about Twitter: @GeorgiaEdeMD This video was recorded at the first ever Metabolic Psychiatry roadmap retreat, hosted by Baszucki Group and the Milken Institute for Strategic Philanthropy in May, 2022 in Santa Barbara. The conference brought together physicians, neuroscientists, dieticians, entrepreneurs, venture capitalists and philanthropists to build community in the emerging field of Metabolic Psychiatry. Learn more about metabolic psychiatry and meet the visionary Metabolic Mind Award Winners at https://tinyurl.com/Baszucki-Group About us: Metabolic Mind™ is a nonprofit initiative incubated by Baszucki Group. Our mission over time will be to provide resources and build community in metabolic psychiatry. JOIN OUR MAILING LIST AT https://metabolicmind.org/ Other resources for Metabolic Psychiatry, metabolic neuroscience and ketogenic metabolic therapy for mental disorders: Diagnosis Diet - https://www.diagnosisdiet.com/ New Study: Serious Mental Illness Improves on Ketogenic Diet - https://www.psychologytoday.com/us/blog/diagnosis-diet/202207/new-study-serious-mental-illness-improves-ketogenic-diet The Role of Ketogenic Metabolic Therapy on the Brain in Serious Mental Illness: A Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728807/ Chris Palmer MD - https://www.chrispalmermd.com/ Stanford Metabolic Psychiatry- https://metabolicpsychiatry.com/ What Is Metabolic Psychiatry? 5 Questions Answered by Dr. Shebani Sethi https://med.stanford.edu/news/all-news/2022/11/metabolic-psychiatry.html Baszucki Group - https://baszuckigroup.com/our-work/metabolism-mental-health/ BipolarCast: Keto + Bipolar youtube channel, Hosted by Matt Baszucki and Iain Campbell, PhD https://www.youtube.com/channel/UCDB-iMvEJ-HeHqpamIN5JWw https://twitter.com/IainCampbellPhD Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. #MetabolicMind #KetoForMentalHealth #MetabolicPsychiatry #BipolarTreatment #MetabolicNeuroscience #KetogenicMetabolicTherapy #NutritionalKetosis #MentalIllnessTreatment #MentalHealthIsMetabolicHealth

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Drs Akshay Jain and Lorenzo Leggio discuss GLP-1 RA therapy and its potential to mitigate alcohol misuse syndrome. https://www.staging.medscape.com/viewarticle/glp-1-ra-therapy-alcohol-use-disorder-2024a1000fur?src=soc_yt --TRANSCRIPT-- Akshay B. Jain, MD: Today we are very excited to have Dr Leggio join us all the way from the National Institutes of Health (NIH). He is an addiction physician scientist in the intramural research program at NIH. Welcome, Dr Leggio. Thanks for joining us. Lorenzo Leggio, MD, PhD: Thank you so much. Jain: We'll get right into this. Your session was, in my mind, extremely informative. The session looked at glucagon-like peptide 1 receptor agonist (GLP-1 RA) therapy and its potential effects on mitigating alcohol misuse syndrome, so, reduction of alcohol addiction potentially. We've seen in some previous clinical trials, including many from your group, that alcohol use is known to be reduced — the overall risk of incidence, as well as recurrence of alcohol use — in individuals who are on GLP-1 RA therapy. Can you share more insights about the data already out there? Leggio: At the preclinical level, we have a very robust line of studies, experiments, and publications looking at the effect of GLP-1 RAs, starting from exenatide up to, more recently, semaglutide. They show that these GLP-1 RAs do reduce alcohol drinking. They used different animal models of excessive alcohol drinking, using different species — for example, mice, rats, nonhuman primates — models that reflect the excessive alcohol drinking behavior that we see in patients, like physical alcohol dependence or binge-like alcohol drinking, and other behaviors in animal models that reflect the human condition. In addition to that, we recently have seen an increase in human evidence that GLP-1 RAs may reduce alcohol drinking. For example, there is some anecdotal evidence and some analyses using social media showing that people on GLP-1 RAs report drinking less alcohol. There are also some pharmacoepidemiology studies which are very intriguing and quite promising. In this case, people have been looking at electronic medical records; they have used the pharmacoepidemiology approaches to match patients on GLP-1 RAs because of diabetes or obesity, and have compared and matched to patients on different drugs as the controls. A study was recently published in Nature Communications by a group in Cleveland in collaboration with Dr Nora Volkow from the National Institute on Drug Abuse. This study shows the association between being on a GLP-1 RA and the lower incidence of alcohol use disorder and lower drinking. There is also some promise from prospective randomized clinical trials. In particular, there was one clinical trial from Denmark, a well-known and -conducted clinical trial where they looked at exenatide, and they didn't see an effect of exenatide compared with placebo in the main analysis. But in a subanalysis, they did see that exenatide reduced alcohol drinking, but only in patients with alcohol use disorder and obesity. This suggests that these medications may work for some patients and not for other patients. That's fine, because just like in any other field in medicine, including diabetes, obesity, hypertension, Parkinson's, and depression, not all medications work for everybody. If these medications will work for alcohol addiction, we do not expect that they will work for everybody. One ongoing question in the field is to try to identify the phenotypes or the subgroup of people who may be more responsive to these medications. Jain: This is such a fascinating field, and all these studies are coming out. In your review of all the literature so far, do you think this is dose dependent? Also, we see that, for instance, with certain individuals, when they take GLP-1 RA therapy, they might have a lot of gastrointestinal (GI) side effects. Recent studies have shown that the rate of these GI side effects does not necessarily correlate with the amount of weight loss. In the alcohol addiction field, do you think that the GI side effects, things like nausea, could also have a potential role in mitigating the alcohol addiction? Leggio: This is a great question. They may play a role; they may contribute, too, but we don't think that they are the driving mechanism of why people drink less, for at least a couple of reasons. One is that, similar to the obesity field, the data we have so far don't necessarily show a relationship between the GI side effects and the reduction in drinking. Plus, the reduction in drinking is likely to happen later when many GI side effects are gone or attenuated. Transcript in its entirety can be found by clicking here: https://www.staging.medscape.com/viewarticle/glp-1-ra-therapy-alcohol-use-disorder-2024a1000fur?src=soc_yt

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