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Recent trends in weight loss emphasize not just shedding pounds but maintaining health and long-term results. Among the top anti-obesity medications—Phentermine, Qsymia, Contrave, Saxenda, and Wegovy—each varies in mechanism, efficacy, side effects, and risk of weight regain. Phentermine suppresses appetite via CNS stimulation but has high yo-yo risk. Qsymia combines Phentermine and Topiramate for stronger effects and moderate rebound risk. Contrave targets emotional eating and shows a lower relapse rate. Saxenda, a daily GLP-1 analog injection, offers good weight loss but mid-level rebound risk. Wegovy, a once-weekly semaglutide injection, delivers the most durable weight loss with the lowest regain risk (only ~40–45% regain after 1 year). Ultimately, the best choice depends on individual lifestyle, medical conditions, and adherence capacity.