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CardioNerds (Drs. Gurleen Kaur and Richard Ferraro) and episode FIT Lead Dr. Spencer Carter (Cardiology Fellow at UT Southwestern) discuss the clinical implementation of GLP-1 receptor agonists with Dr. Neha Pagidapati (Faculty at Duke University School of Medicine). In this episode of the CardioNerds Cardiovascular Prevention Series, we discuss the clinical implementation of glucagon-like peptide-1 (GLP-1) receptor agonists. We cover the clinical indications, metabolic and cardiovascular benefits, and potential limitations of these emerging and exciting therapies. Show notes were drafted by Dr. Spencer Carter. Audio editing was performed by CardioNerds Academy Intern, student Dr. Pacey Wetstein. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. Claim CME for this episode HERE. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - Clinical Implementation of GLP-1 Receptor Agonists GLP-1 agonists work through a variety of mechanisms to counteract metabolic disease. They increase insulin secretion, inhibit glucagon secretion, slow gastric motility, and increase satiety to limit excess energy intake. Patients with type II diabetes and an elevated risk for atherosclerotic cardiovascular disease should be considered for GLP-1 agonist therapy regardless of hemoglobin A1c. GLP-1 agonists offer significant ASCVD risk reduction even in the absence of diabetes. Newer data suggest a significant reduction in cardiovascular events with GLP-1 agonist therapy in patients who are overweight or obese and have a prior history of heart disease. GLP-1 agonists should generally be avoided in patients with a history of medullary thyroid cancer or MEN2. As these medications slow gastric emptying, relative contraindications include history of recurrent pancreatitis and gastroparesis. GLP-1 agonists should be initially prescribed at the lowest dose and slowly uptitrated to avoid gastrointestinal side effects. Show notes - Clinical Implementation of GLP-1 Receptor Agonists What were the groundbreaking findings of the STEP1 and SURMOUNT-1 trials and how these impact cardiovascular wellness? The STEP1 and SURMOUNT trials demonstrated sustained clinically relevant reduction in body weight with semaglutide and tripeptide, respectively, in patients with overweight and obesity. As obesity is an important risk factor for the development of cardiovascular disease, weight reduction meaningfully contributes to cardiovascular wellness. What were the findings of the LEADER trial and their implications for patients with type II diabetes and high cardiovascular risk? The LEADER trial demonstrated a significant reduction in the rate of cardiovascular death, nonfatal MI, or nonfatal stroke in patients with type II diabetes treated with liraglutide. GLP-1 receptor agonist therapy should be considered in all patients with type II diabetes and elevated ASCVD risk regardless of A1c or current hyperglycemic therapy. What are current indications for GLP1 agonists in the context of cardiometabolic disease. GLP-1 receptor agonists should be considered in patients with type II diabetes and high ASCVD risk OR patients without diabetes who are overweight/obese and have a history of cardiovascular disease. What are important side effects or contraindications to GLP1 agents when used for cardiovascular risk reduction and wellness? GLP-1 receptor agonists should be avoided in patients with a history of medullary thyroid cancer or MEN2. Relative contraindications include recurrent pancreatitis, gastroparesis,
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🎙️In this riveting episode, join us as we dive deep into the transformative world of fat loss, intermittent fasting, and the realities of navigating Instagram hate. Coach Shanaya, a renowned fitness expert and wellness coach, shares her personal journey and professional insights that have helped countless individuals redefine their health and self-worth. TO GET FEATURED ON @Shashankfitness MAIL AT: [email protected] IG : https://www.instagram.com/rajput_shashanksingh/ Shanaya's Insta: https://www.instagram.com/coachshanaya/ Shanaya's YT: https://www.youtube.com/@UCvCss6w0h-ln2sK6_LbaFdg Fuelone Protein: https://shorturl.at/gAfKv (Code: SHASHANKFONE for discounts) Episode Highlights: Unlocking the Secrets of Fat Loss: Coach Shanaya breaks down the science behind fat loss, explaining how sustainable weight management goes beyond crash diets and quick fixes. Discover her tried-and-tested methods that focus on nourishing your body, boosting metabolism, and embracing a lifestyle that celebrates long-term success. Intermittent Fasting Demystified: With a surge in popularity, intermittent fasting is more than just a trend—it’s a powerful tool for balancing hormones and optimizing body composition. In this episode, learn about various fasting protocols (like the 16/8 method and extended fasting periods) and how they can be tailored to fit your lifestyle. Coach Shanaya provides clear, evidence-based advice on how to incorporate fasting into your daily routine without sacrificing energy, focus, or your social life. Navigating Instagram Hate in the Digital Age: Social media is a double-edged sword, offering both inspiration and criticism. Coach Shanaya addresses the often-overlooked impact of online negativity, sharing personal experiences and strategies to build resilience against the backdrop of Instagram hate. Learn how to filter out the noise, foster a supportive online community, and use your platform as a source of empowerment rather than self-doubt. Why You Should Listen: Whether you're on the cusp of a fitness journey, looking for ways to break through a plateau, or simply in need of inspiration to overcome digital negativity, this podcast episode is packed with actionable insights and heartfelt advice. Coach Shanaya’s holistic approach integrates physical fitness with mental resilience, offering a balanced perspective that resonates with both beginners and seasoned wellness enthusiasts. Takeaway for Today: For Your Body: Embrace fat loss as a journey of self-care rather than a battle against calories. For Your Mind: Understand that intermittent fasting isn’t just about skipping meals—it’s about tuning into your body’s natural rhythms. For Your Digital Life: Equip yourself with the tools to counteract social media negativity and maintain a positive, authentic online presence. Join the Conversation: We invite you to engage with us—share your thoughts, ask questions, and let us know your experiences with fat loss, intermittent fasting, or dealing with online criticism. Your story might just inspire someone else on their journey to health and happiness. Timestamps: 00:00 - Coming up 00:49 - Introduction 02:10 - Collagen Powder 03:28 - Non worthy supplements 09:29 - Fake and Real Influencers 10:05 - Controversy and attention 11:39 - Ishaan Thakur 15:44 - FuelOne 16:02 - Rohit Chauhan 19:55 - Natural and Enhanced Bodybuilding 24:44 - Money or Fame 28:05 - Amidst Criticism and Hate 32:02 - Supplements for Vegetarians 33:15 - Intermittent fasting and cardio 34:57 - Female content creators 36:22 - Untold Secret 38:15 - Reaction on Hate comments 39:34 - Maturity and Physique 40:25 - Biggest misconception 40:18 - Deload week 42:02 - Old school vs Bio mechanics 49:15 - Confidence and Transformation 51:02 - Smoking and Drinking effect on health 53:20 - Fitness Industry in coming years 55:39 - Strict action to be taken 57:08 - Message to audience 01:02:23 - Outro Don't Forget: Like, subscribe, and hit the notification bell for more insightful discussions with industry experts like Coach Shanaya. Together, let’s pave the way for a healthier, more resilient you! #FatLossJourney #IntermittentFasting #coachshanayapodcast #WeightLossGoals #BurnFat #GetLean #ShredFat #HealthyTransformation #FitnessMotivation #FatLossTips #FitAndHealthy #coachshanaya #shanayasingh #shashanksinghfitness #shashanksinghunfiltered #shanayabiomechanics #youtubepodcast #fitnesspodcast #weightlossfemaleinfulencer #musclebuilding
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The ketogenic diet has gained immense popularity in recent years due to its ability to help with weight loss, manage blood sugar levels, and improve energy levels. One of the challenges of following a keto diet is finding delicious treats that are low in carbs and sugar. This is where Keto Gummies come in, a product that was recently featured on Shark Tank and has been creating quite a buzz in the keto community.
Keto Gummies: What are They?
Keto Gummies are gummy bears that are specifically formulated to be low in carbs and sugar, making them the perfect snack for anyone following a ketogenic diet. These gummies are made with high-quality ingredients such as gelatin, erythritol, and natural flavors, and come in a variety of delicious flavors like raspberry, lemon, and orange. Each serving of Keto Gummies contains just 2g of net carbs, making them a guilt-free treat for keto dieters.
One of the great things about Keto Gummies is that they are convenient and easy to take on the go. Whether you need a quick snack to curb your cravings or a sweet treat to satisfy your sweet tooth, Keto Gummies are the perfect option. They are also free from artificial colors and preservatives, making them a healthier alternative to traditional gummy candies.
Not only are Keto Gummies delicious, but they also provide a source of collagen, which is beneficial for skin, joint, and gut health. Collagen is a protein that is essential for maintaining the structure and integrity of the skin, joints, and digestive system. By incorporating Keto Gummies into your diet, you can support your overall health and well-being while enjoying a tasty treat.
Why Keto Gummies are Worth Trying
There are several reasons why Keto Gummies are worth trying for anyone following a ketogenic diet. Firstly, they are a convenient and delicious way to satisfy your sweet cravings without derailing your diet. By having a pack of Keto Gummies on hand, you can indulge in a tasty treat whenever you feel the urge, without having to worry about consuming too many carbs or sugar.
Additionally, Keto Gummies are a great option for anyone looking to boost their collagen intake. Collagen plays a crucial role in maintaining the health of the skin, joints, and gut, and incorporating Keto Gummies into your diet is an easy way to support these essential functions. With just 2g of net carbs per serving, Keto Gummies are a guilt-free way to enjoy the benefits of collagen.
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Another reason to try Keto Gummies is that they are free from artificial colors and preservatives. Many traditional gummy candies contain artificial ingredients that can have negative effects on your health. By choosing Keto Gummies, you can enjoy a healthier alternative that is made with natural flavors and ingredients.
Where to Buy Keto Gummies
If you’re interested in trying Keto Gummies for yourself, you may be wondering where you can purchase them. Keto Gummies are available for purchase online through the official website, where you can choose from a variety of flavors and sizes. You can also find Keto Gummies in select health food stores and specialty retailers, so be sure to keep an eye out for them during your next shopping trip.
When purchasing Keto Gummies, it’s important to read the product label carefully to ensure that you are getting a genuine product that meets your dietary needs. Look for products that are made with high-quality ingredients and free from artificial additives. By choosing Keto Gummies, you can enjoy a delicious and nutritious snack that supports your keto lifestyle.
In conclusion, Keto Gummies are a tasty and convenient treat that is perfect for anyone following a ketogenic diet. With their low carb and sugar content, natural ingredients, and collagen benefits, Keto Gummies are a great option for satisfying your sweet cravings while staying on track with your diet. Give Keto Gummies a try today and experience the deliciousness for yourself!
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