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It is leptin resistance that is the cause of obesity. Leptin is the hormone which regulates body fat. So it is leptin failure or leptin resistance that is responsible for obesity. Insulin does not regulate body fat. Leptin does. That is why Leptin resistance is the cause of obesity. Not insulin resistance. The gut hormone - GLP-1 is unique in that it is a leptin sensitizer. It reverses leptin resistance. This is why the GLP-1 meds are so effective for obesity. They reverse leptin resistance. It seems that there is a failure in gut GLP-1 production and this is what causes leptin resistance and obesity. The question then is - what causes this failure in gut GLP-1 production and is there anything we can do to fix it?