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Drs Piña and Borlaug discuss the CMR substudy from the SUMMIT trial of tirzepatide in HFpEF/obesity. How does weight loss affect pericardial fat and skeletal muscle? https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt --TRANSCRIPT-- Ileana L. Piña, MD, MPH: Hello. I’m Ileana Piña, from Thomas Jefferson University in Philadelphia, Pennsylvania, and this is my blog. It’s a little bit different blog because I’m really interviewing a good friend about these glucagon-like peptide 1 (GLP-1) inhibitors. Some of our heart failure patients are getting their GLP-1 inhibitors from their primary care physicians, but many questions have arisen with the trial called SUMMIT. With us today is Barry Borlaug, who is in charge of the research section with the cardiovascular section of Mayo, and that is Mayo, Rochester, where it must be much colder even than here in Philadelphia. Barry, congratulations on that trial. Tell our audience a little bit about how the trial was structured because it’s important how we get into your information. SUMMIT Recap Barry A. Borlaug, MD: Thanks, Ileana. SUMMIT was a randomized, double-blind, placebo-controlled trial, testing the GLP-1/glucose-dependent insulinotropic polypeptide (GIP) agonist tirzepatide vs placebo in patients with heart failure with preserved ejection fraction (HFpEF). Unlike some other trials, this was real HFpEF with an ejection fraction of 50% or above. Patients were randomized 1:1 to tirzepatide, titrated up to 15 mg once weekly, or placebo and treated for a minimum of 52 weeks. The dual primary endpoints were worsening heart failure or cardiovascular death and quality of life by the Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score. The median duration of follow-up was 2 years. We continued follow-up until the last patient enrolled completed the full 52-week period of treatment. We found that, as compared to placebo, tirzepatide reduced the risk of worsening heart failure or cardiovascular death by 38%, which was statistically significant, and also improved the KCCQ clinical summary score. In addition to that, we also looked at other patient-centered outcomes like 6-minute walk distance and biochemical markers like C-reactive protein (CRP). We saw that there was also a significant improvement in exercise function measured by 6-minute walk distance and about a 40% decrease in CRP levels. Piña: How long did the total trial last, including the time that the drugs were being administered? Borlaug: The longest duration of follow-up was 3 years, and the median follow-up was 2 years. Piña: Were any of these patients also on sodium-glucose cotransporter 2 ( SGLT2) inhibitors ? Borlaug: Yeah, a minority of patients were also on SGLT2 inhibitors, about 17%. Piña: What was the baseline KCCQ score? Borlaug: Very poor. A s you know, physician-reported heart failure severity often doesn’t agree with patient reports. Overall, 72% of the patients were judged by their physicians to have class II heart failure, but the mean KCCQ score was just over 53, so pretty severe patient-reported limitations or severe HFpEF. Despite this — and this is often the case in HFpEF and obesity-related HFpEF — the median N-terminal pro-B-type natriuretic peptide ( NT-proBNP) was only 175. Piña: I was very surprised at that. Very surprised. That really is low. That was NT-proBNP. That wasn’t BNP. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt
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What are the best supplements for your heart? Our expert shares her tips and top supplements to help your heart. Your heart is one of THE most important organs, and sometimes we need a helping hand making sure we get all our body needs. Katie Brown, product developer at Myprotein is here to tell us what supplements we can use to keep the heart healthy. There are a lot of risk factors for poor heart health; heart disease, diabetes, high blood pressure, high cholesterol and things that we can’t change like genetics, age and gender, which puts us all at a different level of risk. A range of lifestyle factors can also play a role, including if you smoke, your exercise regularity, if you’re stressed or if you’re not getting enough sleep. Of course, having a balanced diet can help keep your heart healthier. But seriously, heart problems aren’t a joke. If you have any symptoms of heart disease or any other heart related problems, please speak to your doctor. *** Chapters: 00:00 - Introduction 00:40 - What are the risk factors? 01:11 - How fibre can help 02:15 - How much fibre should you have? 02:37 - Increasing Stanol intake 03:05 - Balancing salt intake 03:25 - Supplements that help heart health 04:57 - Any more heart health questions? ********************************* Subscribe to our channel: https://www.youtube.com/user/MyproteinUK?sub_confirmation=1 If you like this, you'll love this: https://youtu.be/W2F37FrEJsA Find more expert advice here: https://www.youtube.com/watch?v=IbLIyA6AlS4&list=PLkb17OgnhB-E3HuYJuEacRqMjrokvPxpI Download the Myprotein App: https://bit.ly/3dhVVUE ********************************* #HeartHealth #SupplementsToHelpHeart #MyProtein Heart Health: What Supplements Do You Need? | Nutritionist Explains... | Myprotein Official YouTube channel for Europe's No. 1 Online Sports Nutrition Brand, Myprotein. Stay tuned for brand new videos every single week that help to inspire and motivate you to keep pushing further on your fitness journey. From challenging workouts to evidence-based nutrition videos — we've got it all.
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Kelly Clarkson’s 40-Pound Weight Loss: Her Secret Diet Revealed! Join this channel to get access to perks: https://www.youtube.com/channel/UC8JFa_zl1NRxeRKyeVfLzjQ/join About Jaxcey N24: The Jaxcey N24 team brings you the latest breaking entertainment, fashion and Pop Culture news. Featuring exclusive segments, celebrity highlights, trend reports and more, the Jaxcey N24 channel Subcribe now. ⚠ All information disseminated in this video is collected from respective websites / books / journals / magazines / national and international media / documentaries. ⚠ Some images used in this video do not represent actual persons, events, times or places; It is used to fill the void in the scene. ⚠ After downloading this video, do not redistribute it in any form of promotion. Copyright Disclaimer: =================== This channel may use some copyrighted materials without specific authorization of the owner but the contents used here fall under “Fair Use”. Copyright Disclaimer under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair use. If you have any issue, problem or query feel free to mail us. Anti-Piracy Warning: This content is copyrighted to Jaxcey N24. Any unauthorized reproduction, redistribution, or re-upload is strictly prohibited from this material. Legal action will be taken against those who violate the copyright of the following material presented.
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What if looking good and feeling good were two sides of the same coin? In this eye-opening conversation with Mary Kelly and Jemika Sivak from Skin Sanctuary Med Spa and Integrative Health, we dive deep into the fascinating world where beauty treatments meet functional medicine. The duo shatters common misconceptions about aesthetic procedures like Botox, explaining how these treatments have evolved far beyond Hollywood celebrities to become accessible options for everyday wellness. You'll discover the science behind collagen stimulation, learning how innovative techniques like PRF (Platelet-Rich Fibrin) use your body's own healing mechanisms to rejuvenate skin and even restore hair. Their strategic approach focuses not on freezing expressions but on enhancing natural features while preventing signs of aging. But this conversation goes much deeper than skin deep. We explore the revolutionary concept of "health span" versus "lifespan," addressing why so many people spend their retirement years managing preventable chronic conditions instead of thriving. Jemika breaks down the functional medicine approach that looks at root causes rather than symptoms, explaining the crucial connection between gut health and everything from mental clarity to immune function. Most shocking is their revelation that the "Four Horsemen" of modern health—heart disease, cancer, neurodegenerative diseases, and type 2 diabetes—are up to 80% preventable through lifestyle choices. Whether you're curious about red light therapy's ability to recharge your cellular batteries or wondering about the real story behind weight loss medications like GLP-1 agonists, this episode delivers practical wisdom without judgment. The experts emphasize that perfection isn't necessary—making healthy choices just 80% of the time can dramatically improve your quality of life. Ready to reimagine your approach to aging and wellness? This conversation might just change how you think about the connection between looking good, feeling good, and living well. #botox #glp-1 #guthealth #bradweisman #skinsantuarymedspa
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The Keto Diet has become increasingly popular in recent years, with many people turning to this low-carb, high-fat diet to help them lose weight and improve their overall health. However, like any diet plan, sticking to the Keto Diet can be challenging, especially for those who lead busy lifestyles and don’t always have time to prepare healthy meals. This is where Keto Diet pills come in, offering a convenient way to supplement the diet and help users stay on track with their weight loss goals.
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When Keto Diet pills first made an appearance on Shark Tank, they were met with a mix of skepticism and excitement. Some of the sharks were wary of the claims made by the entrepreneurs behind these pills, while others saw the potential for a lucrative business opportunity. Despite the initial skepticism, Keto Diet pills began to gain traction in the market as more and more people started to see results from using them.
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As the popularity of the Keto Diet continued to grow, so too did the demand for Keto Diet pills. Entrepreneurs on Shark Tank saw an opportunity to capitalize on this trend and began to pitch a variety of Keto Diet pills to the sharks. Some of these products focused on boosting energy levels and improving athletic performance, while others emphasized their ability to support mental clarity and focus.
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Over time, Keto Diet pills evolved to offer a range of benefits beyond just weight loss. Some products claimed to improve skin health, reduce inflammation, and even enhance cognitive function. These additional benefits made Keto Diet pills even more appealing to a wide range of consumers looking to improve their overall well-being.
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As the Keto Diet continues to gain popularity and more research is conducted on its health benefits, the future of Keto Diet pills looks promising. With advancements in technology and a growing understanding of how the body responds to different nutrients, we can expect to see even more innovative Keto Diet pills hitting the market in the years to come.
Whether you’re looking to lose weight, boost energy levels, or improve your overall health, Keto Diet pills offer a convenient and effective way to support your goals. By incorporating these supplements into your daily routine and pairing them with a balanced diet and regular exercise, you can maximize the benefits of the Keto Diet and achieve lasting results.
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Looking for quick weight loss? Think again! In this short clip from our podcast, Nutritionist & Dietitian Nidhi Mehra Ji explains why weight loss is a gradual process — just like weight gain doesn’t happen overnight, neither does fat loss. ✅ What you’ll learn: Why slow and steady weight loss is sustainable The dangers of fast crash diets Importance of consistency, not shortcuts Mindset shift needed for real transformation 🎯 Be patient. Trust the process. Stay consistent. 🔔 Subscribe for more expert wellness insights and realistic health advice. ------------------------------------- *About Healthy Podcast* ------------------------------------- Welcome to The Healthy Podcast, your ultimate guide to health and wellness! Where we interact with doctors and experts on common health problems and bring their suggestions and practical solutions to you. *Follow Us on:* Instagram:- https://www.instagram.com/healthypodcastofficial FB: https://www.facebook.com/healthypodcastofficial Website: https://healthypodcast.in/ Here, you'll find a wide range of topics related to health, wellness, fitness, nutrition, mental health, and more. Our team of experienced professionals and specialists work diligently to bring you the latest insights and research-based tips. #HealthyPodcast #HealthTips #Wellness
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Taking control of your GLP-1 weight loss journey just got easier! If you're using medications like Ozempic, Wegovy, Mounjaro, or Saxenda, managing your injections and staying on track is key. Introducing Shotwise – your ultimate companion app designed to simplify your GLP-1 treatment and help you monitor your progress effortlessly. Shotwise is all about making your GLP-1 journey smoother. Never miss another dose with our injection scheduler and customizable reminders. Quickly and easily log your injections, including dose details and injection sites, so you can avoid overlaps and stay organized. Plus, visualize your weight loss progress with our intuitive weight tracker, detailed charts, and trends. Seeing your injection history and weight trends together gives you valuable insights into your treatment. Tailor Shotwise to your life with customizable notifications, ensuring managing your GLP-1 treatment for weight loss is truly hassle-free. Whether you're using Ozempic, Wegovy, Mounjaro, Zepbound, or another GLP-1 medication, Shotwise is here to support you. Ready to simplify your GLP-1 experience and stay motivated on your weight loss journey? Learn more about Shotwise and download the app today! #GLP1 #WeightLoss #Ozempic #Wegovy #Mounjaro #Zepbound #Saxenda #GLP1App #InjectionTracker #WeightLossApp #HealthApp #Shotwise #GLP1Treatment #WeightManagement #GLP1WeightLoss #WeightLossJourney #MedicationManagement
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