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Calling all those with a passion for cardiovascular prevention! In this episode of the CardioNerds Cardiovascular Prevention Series, we take a deep dive into the world of glucagon-like peptide-1 (GLP-1) receptor agonists. Along the way, you’ll hear about the biology of the GLP-1 molecule and its related peptides, learn more about how GLP-1 agonists promote glycemic control, weight loss, and cardiometabolic health, and explore the current body of literature supporting the individualized application of these medications to patients with diabetes, obesity, and/or ASCVD. Join Dr. Christian Faaborg-Andersen (CardioNerds Academy Fellow and Internal Medicine Resident at MGH), Dr. Gurleen Kaur (Director of the CardioNerds Internship, Chief of House Einthoven, and Internal Medicine resident at BWH), and Dr. Rick Ferraro (CardioNerds Academy House Faculty and Cardiology Fellow at JHH) for a wide-ranging discussion on GLP-1 and GIP agonists with Dr. Dennis Bruemmer (Cardiologist and Director of the Center for Cardiometabolic Health in the section of Preventive Cardiology at the Cleveland Clinic). Show notes were drafted by Dr. Christian Faaborg-Andersen. Audio editing was performed by CardioNerds Academy Intern, student Dr. Tina Reddy. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. Claim CME for this episode HERE. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - GLP-1 Agonists: Mechanisms to Applications The selection and dosing of GLP-1 and GIP agonists (GLP-1s and GIPs) depends on their intended use as an anti-glycemic or anti-obesity agent. The cardiovascular benefits of GLP-1s and GIPs may be independent of improvements in glycemic control, and in part be driven by reduction in inflammation, a key driver of arterial plaque formation. In patients with comorbid coronary artery disease, obesity, and diabetes, GLP-1 agonists and SGLT-2 inhibitors should be used as first-line agents, over metformin. Tirzepatide is a dual agonist that activates GIP and GLP-1 receptors. GIP is highly expressed in the brain, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Caution should be used with GLP-1 agonists in patients with long-standing diabetes complicated by gastroparesis, as well as incompletely treated diabetic retinopathy. GI upset is not uncommon with GLP-1/GIP agonists, and switching to a different agonist is unlikely to help. Show notes - GLP-1 Agonists: Mechanisms to Applications What are the mechanisms of action by which GLP-1 and GIP controls blood sugar and body weight? Glucagon-like peptide-1 (GLP-1) is an endogenous hormone that is secreted in response to an oral glucose load. It promotes insulin release, inhibits glucagon secretion, and slows gastric emptying via the brain-intestine axis, leading to satiety. GLP-1 agonists are medications that mimic the effect of this hormone and, on average, lower hemoglobin A1C by 0.8% to 1.5%. These medications include semaglutide, liraglutide, and dulaglutide. Glucose-dependent insulinotropic polypeptide (GIP) is also an endogenous hormone, similarly secreted by the body in response to an oral glucose load such as a meal. GIP is highly expressed in the arcuate nucleus and hypothalamus, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Tirzepatide is a dual GLP-1/GIP agonist. What is the role of GLP-1/GIP agonists in patients with overweight/obesity and/or type 2 diabetes? How does the dosing of GLP-1/GIP medications change with their intended disease target?
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When it comes to managing erectile dysfunction (ED), people are constantly seeking natural remedies to alleviate symptoms and improve their overall sexual health. One emerging trend in the market is the use of CBD gummies, which are infused with cannabidiol (CBD), a compound derived from the cannabis plant known for its potential health benefits. In recent years, CBD has gained popularity for its analgesic, anti-inflammatory, and anti-anxiety properties. But can CBD gummies really help with ED, and what is their potential for weight loss enthusiasts? In this article, we will explore the reviews on CBD gummies for ED and decipher their potential benefits for individuals looking to improve their sexual health and support their weight loss journey.
The Science Behind CBD Gummies
CBD, one of the many cannabinoids found in the cannabis plant, interacts with the endocannabinoid system in the body, which plays a crucial role in regulating various physiological processes, including mood, appetite, pain sensation, and reproductive function. By influencing the endocannabinoid system, CBD may help alleviate symptoms associated with ED, such as stress, anxiety, and inflammation, which can contribute to erectile problems. Additionally, CBD has been shown to improve blood flow and circulation, which are essential for achieving and maintaining an erection.
When it comes to weight loss, CBD may also have some potential benefits. Studies have found that CBD can help regulate metabolism, reduce appetite, and promote fat browning, a process where white adipose tissue is converted into brown fat, which burns calories to generate heat. By supporting these mechanisms, CBD gummies may aid weight loss enthusiasts in achieving their goals by helping them control their appetite, boost their metabolism, and burn fat more effectively.
Reviews on CBD Gummies for ED
Many individuals have reported positive experiences with using CBD gummies to manage their ED symptoms. Some users have noted that CBD helps them relax, reduces performance anxiety, and enhances sensations, leading to improved sexual performance and satisfaction. Additionally, CBD gummies are convenient and discreet, making them a popular choice for individuals looking for a natural and non-invasive solution to their ED concerns.
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When it comes to weight loss, CBD gummies have also received positive feedback from users who have incorporated them into their wellness routines. Many individuals have reported that CBD gummies help curb their cravings, boost their energy levels, and support their overall weight loss efforts. By providing a tasty and convenient way to consume CBD, gummies make it easier for individuals to incorporate this compound into their daily regimen and reap its potential benefits for weight management.
Final Thoughts
Overall, CBD gummies show promise as a natural remedy for individuals dealing with ED and seeking to support their weight loss journey. With their potential to alleviate stress, anxiety, and inflammation, as well as regulate metabolism, reduce appetite, and promote fat browning, CBD gummies offer a holistic approach to improving sexual health and achieving weight loss goals. As with any supplement, it is essential to consult with a healthcare provider before incorporating CBD gummies into your routine to ensure they are safe and suitable for your individual needs. By harnessing the power of CBD gummies, individuals can potentially enhance their sexual performance, support their weight loss efforts, and improve their overall well-being.
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Are you looking to enhance your keto diet with a convenient and delicious supplement? Look no further than Keto Prime Gummies! These gummies are specially formulated to support your keto journey by providing you with the essential nutrients and benefits you need to stay on track and reach your goals. With Keto Prime Gummies, you can enjoy the benefits of a keto-friendly supplement in a tasty, easy-to-use gummy form.
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Keto Prime Gummies are designed to support your keto lifestyle by providing you with a powerful combination of ingredients that can help boost your energy levels, improve mental clarity, and enhance your overall well-being. These gummies contain key nutrients like exogenous ketones, MCT oil, and collagen, which are essential for maintaining ketosis and promoting fat burning. By incorporating Keto Prime Gummies into your daily routine, you can stay on track with your keto diet and experience greater results.
One of the main benefits of Keto Prime Gummies is their ability to help curb cravings and reduce hunger, making it easier for you to stick to your keto diet and avoid the temptation of unhealthy snacks. By providing your body with the nutrients it needs to stay in ketosis, these gummies can help you stay focused and energized throughout the day, allowing you to stay on track with your weight loss goals.
In addition to supporting your keto lifestyle, Keto Prime Gummies are also a convenient and delicious way to enjoy the benefits of a keto-friendly supplement. With their tasty fruit flavors and easy-to-use gummy form, these gummies are a convenient option for busy individuals who are looking for a simple and enjoyable way to enhance their keto diet. Simply take the recommended dose each day to experience the benefits of Keto Prime Gummies.
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When you choose Keto Prime Gummies, you can experience a range of benefits that can help support your keto diet and improve your overall health. These gummies are packed with essential nutrients and ingredients that can help boost your energy levels, enhance your mental clarity, and support healthy weight loss. By incorporating Keto Prime Gummies into your daily routine, you can enjoy the following benefits:
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Results may vary for each individual, but many users report experiencing benefits within a few weeks of using Keto Prime Gummies regularly. Consistency is key, so be sure to take the gummies as directed to maximize their effectiveness.
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