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In continuation of my update "Metformin" GLP-1 receptor agonists, a class of drug used to treat type 2 diabetes, likely trump the widely prescribed metformin for curbing dementia risk in people with the condition, finds the largest study of its kind, published in the open access journal BMJ Open Diabetes Research & Care. The findings suggest that future clinical guidelines for the treatment of type 2 diabetes would do well to consider prioritizing drugs with both blood glucose and neuroprotective effects, say the researchers. Published research suggests that both GLP-1 receptor agonists and metformin, which are widely used to treat type 2 diabetes, protect the brains of people with the disease. But as yet there have been no direct real-world comparisons of the potential impact of these drugs on dementia risk—a risk that is around 70% higher in people with type 2 diabetes. To explore this further, the researchers drew on anonymized electronic health records from a global health research network (Trinetx) spanning the period 2004 to 2024 to track the development of dementia in patients with type 2 diabetes, treated with either GLP-1 receptor agonists or metformin (87,229 patients in each group; average age 58) for at least six consecutive months. There was no significant difference in vascular dementia risk between the two types of drug when used as first line therapy. But GLP-1 receptor agonist use was associated with a significantly lower cumulative (10%) risk of developing dementia, overall, with an incidence of almost 2.5% (2,130 people) compared with an incidence of nearly 5% (4,215 people) for metformin. And specifically, taking this type of drug was associated with a 12% lower risk of developing Alzheimer's disease, and a 25% lower risk of developing non-vascular dementias than metformin use. Further in-depth analyses showed that these positive effects were evident across all age groups, but with the strongest effect among the over 60s, women, and those of white ethnicity. Risk of death from any cause was also lower: nearly 5% of those treated with GLP-1 receptor agonists died compared with nearly 9% of those treated with metformin. "Both medications demonstrate neuroprotective properties, such as reducing neuroinflammation and oxidative stress, improving insulin sensitivity, and enhancing cerebrovascular health, which likely contribute to their benefits in overall dementia," explain the researchers. But unlike metformin, whose benefits primarily derive from systemic metabolic effects, GLP-1 receptor agonists exert direct central nervous system effects by crossing the blood-brain barrier, they add. "However, the multifactorial nature of [vascular dementia], driven by cerebrovascular damage, such as small vessel disease and white matter lesions, poses significant challenges for pharmacological interventions targeting metabolic or neurodegenerative pathways," they continue. This is an observational study, and as such, no firm conclusions can be drawn about cause and effect. And the researchers point out that the tracking period, while sufficient for observing dementia outcomes, may not fully capture long-term cognitive effects, especially given the progressive nature of Alzheimer's disease. REF:https://www.med-chemist.com/2025/07/glp-1-diabetes-drugs-likely-trump.html
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Oprah Keto Pills have become a buzzword that has been associated with Shark Tank show. Many individuals are interested in this product that guarantees weight loss quickly without any extra efforts on your part. However, there are conflicting reports about these pills and whether they were endorsed by the popular television program. This article will delve into the truth and fiction regarding Oprah keto pills in shark tank.
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However, even with these contradictory accounts, people still want to know more about Oprah Keto Pills. These pills allegedly contain a special blend of ingredients which enable your body to enter ketosis where it starts using fat for energy instead of carbohydrates. The result is rapid weight loss and high energy levels which make it an ideal option for those who want to lose weight within a short period.
Another assertion regarding the Oprah Keto Pills is that they have proven effective within weeks and can be used by anybody to cut down their weight drastically. Some users have stated losing a lot of pounds after taking them for only few days or week as reported by most of consumers who posted their comments online. This has further increased interest in it and led to arguments as concerns its safety and efficacy.
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However, it is important to be cautious with products like the Oprah Keto Pills and do some research before testing them. Nonetheless, a visit to a healthcare professional is always recommended for advice on any new loss procedure. Furthermore, different people have different responses hence only that which is good for one individual may be bad for another.
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Although semaglutide weight loss pills offer convenience and ease of use, some individuals may prefer the injections for a variety of reasons. Injections may provide a more consistent and controlled delivery of the medication compared to pills, which could lead to better results in some cases. Additionally, some individuals may prefer the injection form if they have concerns about the absorption of the medication when taken orally.
Clinical trials have shown that semaglutide injections can be highly effective in promoting weight loss. Individuals taking semaglutide injections have typically experienced significant weight loss compared to those taking a placebo. This weight loss is often sustained over a long period, making semaglutide injections a promising option for individuals looking to lose weight and improve their health.
In addition to weight loss, semaglutide injections have been shown to have other positive effects on health. Studies have demonstrated that semaglutide can help improve blood sugar levels, reduce the risk of cardiovascular events, and improve overall metabolic health. This makes semaglutide injections a comprehensive treatment option for individuals looking to improve both their weight and their overall health.
Comparison of Semaglutide Weight Loss Pills and Injections
When comparing semaglutide weight loss pills and injections, it is important to consider individual preferences and needs. Some individuals may prefer the convenience and ease of use of the pills, while others may prefer the consistency and control of the injections. Both forms of semaglutide have been shown to be effective in promoting weight loss and improving health, so the choice between the two may ultimately come down to personal preference.
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