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With millions of people now taking GLP-1 agonists like Ozempic and Wegovy, I was curious to learn if there are known genetic mutations that predispose people to have serious side effects from these medications. So exploring the pharmacogenomic aspects of Ozempic and Wegovy. To answer these questions Dr. Josiah Allen is joining the show. Josiah Allen, PharmD, has spent over 15 years in the field of pharmacogenomics, beginning at the Mayo Clinic where he helped develop the GeneSight test. As a founding employee and the first medical science liaison at Assurex Health, he helped GeneSight become one of the fastest growing molecular diagnostic tests in history. He later served as director of medical affairs at OneOme and now works at St. Elizabeth Healthcare in Edgewood, KY, as a precision medicine pharmacist and PGY2 Clinical Pharmacogenomics pharmacy residency program director. He earned his bachelor's degree in psychology from Wheaton College and his Doctor of Pharmacy degree from the University of Minnesota. Topics Covered: The basics of pharmacogenomics and its role in personalized medicine. How genetic mutations, like those in the RET gene, influence medication risks. The pharmacogenomics of GLP-1 agonists (like Ozempic and Wegovy), including their contraindications for patients with RET mutations. Insights into the overlap between ACMG secondary findings and pharmacogenomic implications. Case studies illustrating the real-world impact of pharmacogenomics. Key Takeaways: GLP-1 agonists, such as Ozempic and Wegovy, carry a black box warning due to an association with thyroid cancer, particularly in individuals with RET gene mutations. Over one-third of the ACMG secondary findings genes have pharmacogenomic implications, emphasizing the need for clinicians to integrate genetic insights into prescribing practices. Pharmacists and geneticists need closer collaboration to bridge the gap between clinical genomics and pharmacogenomics for safer medication use. Get ready, genetic nerds—another brand-new episode of DNA Today drops next Friday! You can always count on us to deliver fresh content every Friday. While you wait, why not dive into our library of over 300 episodes? Binge them all on Apple Podcasts, Spotify, our website, or wherever you love to listen—just search “DNA Today.” DNA Today is hosted and produced by Kira Dineen, MS, LCGC, CG(ASCP)CM . Our Video Lead is Amanda Andreoli. Our Social Media Lead is Kajal Patel. Our Outreach Intern is Liv Davidson. And our logo Graphic Designer is Ashlyn Enokian, MS, CGC. See what else we are up to on Instagram, X (Twitter), BluSky, Threads, LinkedIn, Facebook, YouTube all at DNATodayPodcast. Our website is DNAToday.com. Questions/inquiries can be sent to [email protected].

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Join this channel to get access to perks: https://www.youtube.com/channel/UCnQiofnuXFcloJRoJTsc1FQ/join Download my FREE GLP-1/GIP Medication Information Sheet: http://eepurl.com/gdB2qn Subscribe to the channel: https://www.youtube.com/@theofficialdrdan?sub_confirmation=1 Watch my previous videos about how to fight obesity and about the best medicine for weight loss: ▪️ Watch This Before Taking Mounjaro: https://youtu.be/BmkVtGgejhk ▪️ From Ozempic to Mounjaro: https://youtu.be/L9e46iFWwIs ▪️ Muscle Loss with Ozempic, Wegovy & Mounjaro: https://youtu.be/lnEH-v64aG0 ▪️ Managing Nausea from Ozempic, Wegovy and Trulicity!: https://youtu.be/3R1Fwhf02LE ▪️ Ozempic: Stomach Paralysis Update: https://youtu.be/MPyROywaM0g ▪️ How to Switch from Ozempic (or Wegovy) to Mounjaro: https://youtu.be/L9e46iFWwIs ▪️ Ozempic Paralyzed My Stomach: https://youtu.be/tj9thkkN5aM ▪️ How to Inject Mounjaro: step-by-step tutorial: https://youtu.be/piVHr7UqYDg – Live in Alberta? Come see me at my Pharmacist-led Obesity Clinic at Apothecare Pharmacy - http://apothecarerx.ca – Products to support your weight-loss journey: USA: https://amzn.to/3RC7MSd Canada: https://amzn.to/45gq4vg – Sign up for my newsletter: http://eepurl.com/gdB2qn – Contact Me: [email protected] – Have questions or need support on your weight-loss journey? Book a consultation with me: https://calendly.com/drdanconsult/he – For more about weight loss via habit mastery, visit https://www.healthevolved.co Join me on social media: ▪️ https://www.facebook.com/theofficialdrdan ▪️ https://www.instagram.com/theofficialdrdan ▪️ *NEW TIKTOK ACCOUNT: https://www.tiktok.com/@officialdrdan #weightloss #obesity #obesitymedicine #ozempicweightloss #weightlossjourney #ozempic #mounjaro #youtubeshort #youtubeshorts #wegovy #weightlosstips #howtolosebellyfat #howtoloseweight #howtoloseweightfast #weightlossmedication #weightlosschallenge