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Three drugs: Liraglutide (Saxenda), Semaglutide (Wegovy), and Tirzepatide (Zepbound / Mounjaro) have been licensed for weight loss in patients who are overweight or obese. In this video I will discuss the mechanisms of action of these medicines, the licensed indications, method of administration, efficacy, side effects, and what happens to body weight after stopping treatment. TIMESTAMPS: 00:00 Introduction 00:26 Licensed Drugs 01:37 Mechanisms of Action 05:45 Licensed Indications 06:32 Method of Administration 07:14 Efficacy 08:49 Side Effects 09:47 Stopping Treatment References: Liraglutide: . SCALE Diabetes trial: https://pubmed.ncbi.nlm.nih.gov/26284720/ . SCALE Maintenance trial: https://pubmed.ncbi.nlm.nih.gov/23812094/ . SCALE Obesity & Prediabetes: https://pubmed.ncbi.nlm.nih.gov/26132939/ Semaglutide: . STEP 1 trial: https://pubmed.ncbi.nlm.nih.gov/33567185/ . STEP 2 trial: https://pubmed.ncbi.nlm.nih.gov/33667417/ . STEP 3 trial: https://pubmed.ncbi.nlm.nih.gov/33625476/ . STEP 4 trial: https://pubmed.ncbi.nlm.nih.gov/33755728/ Tirzepatide: . SURMOUNT 1: https://pubmed.ncbi.nlm.nih.gov/35658024/ . SURMOUNT 2: https://pubmed.ncbi.nlm.nih.gov/37385275/ . SURMOUNT 3: https://pubmed.ncbi.nlm.nih.gov/37840095/ . SURMOUNT 4: https://pubmed.ncbi.nlm.nih.gov/38078870/ Liraglutide vs Semaglutide: . STEP 8 trial: https://pubmed.ncbi.nlm.nih.gov/35015037/ What happens to body weight after stopping treatment: . SURMOUNT 4: https://pubmed.ncbi.nlm.nih.gov/38078870/ . STEP 4 trial: https://pubmed.ncbi.nlm.nih.gov/33755728/ . Liver Inte. 2019;39:941-949: https://pubmed.ncbi.nlm.nih.gov/30721572/ Other References: Effect of dual GIP / GLP-1 on Weight loss: https://pubmed.ncbi.nlm.nih.gov/36909312/ This video is purely of educational purposes and is intended for primary care physicians. It is not and should not be used by patients to treat themselves. The advice is to always speak to your doctor and follow his or her advice with regards to any condition you have or any treatment you are likely to undertake. #semaglutide #tirzepatide #wegovyweightloss #mounjaroweightloss #weightlossmedication #saxenda #glp1

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Building more muscle does not actually help you burn more calories. This is a myth that refuses to die, and it's been championed by fitness gurus for decades. But the truth is, building more muscle doesn't actually make that much difference in terms of how many calories you burn. As an example, adding an extra pound of muscle will help you burn another 4 to 7 calories per day at rest. That means if you build 10 pounds of muscle, with pure muscle, you're going to be burning an extra 40 to 70 calories per day. That's not even the same amount as an apple. So why is muscle building so important and what's the relationship with fat loss? It's not about how much muscle burns at rest. It's about what happens to your body after a training session. During a typical low intensity workout like walking, your body has an elevated level of calorie burning for up to 30 minutes after you're done exercising. Not much of a boost. But with weight training, what you get is a 24-hour boost in calorie burning potential. This is called post-exercise oxygen consumption. The microscopic damage and stress on your body requires that your body upregulate its calorie burning potential for the next day or two. This is where you really get the calorie burning impact. So, while building more muscle will not necessarily help you burn more calories just because muscle is sitting on your body, the lifestyle that leads to building muscle does help you burn more calories. Beyond that, we know that muscle mass is positively correlated with all-cause mortality, better insulin regulation and several other factors that improve metabolic health. So, despite the truth about this myth of muscle burning more calories at rest, it is important to weight train if you're looking at losing fat. Resistance training should absolutely be part of your weight loss regimen. Follow me for more practical health tips and to learn how to rebuild your body pain-free.

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