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🚀 Stay ahead in combination products, pharma, and medical devices 👉 https://www.letscombinate.com 🎙️ Listen to more expert discussions on regulations, drug delivery, and quality 👉 https://www.letscombinate.com/ Get expert insights on FDA regulations, risk management, quality systems, and the latest trends in drug-device combination products. Ben Locwin discusses the science, quality, and future of GLP-1 receptor agonists, revolutionary drugs used in diabetes and obesity treatment. The episode explores the history and development of GLP-1s, their commercial viability, manufacturing challenges, and regulatory landscapes. Ben dives into the mechanisms of GLP-1s, including their influence on appetite, blood sugar, and gastrointestinal effects. They also touch on the capacity issues in production, the impact of compounding, and the sustainability concerns associated with injector pens. The conversation provides an in-depth look at the pharmaceutical industry’s response to the surge in GLP-1 demand, highlighting the broader implications for patient care and market trends. 00:00 Introduction to GLP Receptor Agonists 00:46 Guest Introduction: Ben Locwin 01:48 Historical Context of GLP-1 Development 05:54 Mechanisms and Effects of GLP-1 09:51 Market Impact and Manufacturing Challenges 11:16 Regulatory and Advertising Considerations 17:44 Sustainability and Injector Pen Issues 19:40 Risk Management and Future Directions 23:31 Conclusion Ben Locwin is a Healthcare Executive, MMA fighter, Jiu Jtisu pro and Quality and Regulatory SME working in medical devices, pharma and other regulated industries. Subhi Saadeh is a Quality Professional and host of Let's Combinate. With a background in Quality, Manufacturing Operations and R&D he's worked in Large Medical Device/Pharma organizations to support the development and launch of Hardware Devices, Disposable Devices, and Combination Products for Vaccines, Generics, and Biologics. Subhi serves currently as the International Committee Chair for the Combination Products Coalition(CPC) and as a member of ASTM Committee E55 and also served as a committee member on AAMI's Combination Products Committee. For questions, inquiries or suggestions please reach out at letscombinate.com or on the show's LinkedIn Page.

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This video explains what GLP-1 is, describing it as a hormone released in the gut after eating food, influencing appetite control. It covers how GLP-1 signals the body to stop eating and slows digestion so nutrients can be absorbed, affecting weight management. Learn about how this system works in your body. _________________________________________________________ CHAPTERS 00:00 – What GLP-1 Does in the Body 00:44 – How It Suppresses Appetite 01:11 – Hormones, Metabolism & Weight Loss 01:35 – Muscle Loss Risks with GLP-1s 02:06 – Glucose Control & Cardiovascular Benefits 03:14 – Brain Health & Fasting Support 03:40 – Common Side Effects & GI Issues 04:12 – Long-Term Concerns: Retinopathy & Cancer Risk 05:34 – Unknowns of Long-Term Use 06:22 – Liraglutide vs Semaglutide 06:39 – Starting Doses & Caution on Overdosing 07:59 – Who Should Avoid GLP-1s 09:13 – Animal Studies & Thyroid Cancer Debate 10:06 – Drug & Supplement Interactions ▶️▬▬▬▬💰Support the Channel 👉 Products, Sponsors, and Referrals Codes💰▬▬▬▬◀️ Lvlup Health - Purchase Peptides like BPC-157 and Professional Grade Supplements: ➢💊https://lvluphealth.com/?ref=DrMoe = Use Code "DrMoe15" for 15% off 💸 Methylene Blue Troches ➢🔵 https://bit.ly/4hoBB1N = use code DRMOE for discount 💸 Cosmic Nootropic - Phenylpiracetam and Nootropics ➢https://tinyurl.com/CosmicNootropicDrMoe 💸 Get 10% off with code DRMOE 💸 My Linktree ➢https://linktr.ee/dr.michaelmoeller Connect with Dr. Moeller ~ 📺 Click here to Subscribe: @DrMichaelMoeller 📲 Instagram: https://www.instagram.com/dr.michaelmoeller/ ⏰ TikTok: https://www.tiktok.com/@dr.michaelmoeller?is_from_webapp=1&sender_device=pc ____________________________ The information in this video is for informational and educational purposes only and is not intended as medical advice. It reflects the opinions of Dr. Michael Moeller and is provided for entertainment and general knowledge. This content is not a substitute for professional medical guidance, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions regarding your health, especially before starting any new supplement, nutrition, or lifestyle program. Dr. Michael Moeller and the publisher of this content are not responsible for any health outcomes related to the use of this information. Viewers taking prescription or over-the-counter medications should seek medical advice before making any changes.

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