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In this presentation from CKD Update 2024, Dr. Satinath Mukhopadhyay explores the renal benefits of combining SGLT2 inhibitors and GLP-1 receptor agonists in patients with type 2 diabetes. He discusses the additive and possibly synergistic effects of this combination in improving renal outcomes, reducing eGFR decline, and enhancing cardiovascular and metabolic control. The session highlights key trials such as FLOW, and explains the underlying mechanisms of action, including inflammation reduction, fibrosis regulation, and improved sodium handling in the kidneys. Key points covered: * A case study showing renal improvement with SGLT2 inhibitors and GLP-1 receptor agonists * The FLOW trial outcomes and benefits of the combination therapy * The mechanisms of action, including effects on blood pressure, weight, and glycemic control * The importance of combination therapy in improving renal outcomes in type 2 diabetes * Proposals for optimal renal protection therapies in diabetic patients Dr. Mukhopadhyay also addresses the practical considerations of this therapy, including the potential challenges due to costs and coverage.
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