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Robert A. Gabbay, MD, PhD, discusses the use of basal insulin in combination with a glucagon-like peptide-1 receptor agonist for the treatment of patients with diabetes.

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Are you feeling trapped on a fat loss plateau with no idea why? You've been eating clean, hitting the gym, and even cutting calories, yet the scale refuses to budge. It’s frustrating and can make you doubt your entire wellness journey. But what if I told you there's a crucial mindset shift you need to embrace to unleash your body's natural fat-burning power? In this video, we’ll explore the shocking reasons behind your stalled weight loss and share powerful tips to rev up your metabolism, cultivate healthy habits, and finally achieve the weight loss results you’ve been striving for. Get ready to smash through that plateau and start shedding pounds for good! ============================================================== Disclaimer https://docs.google.com/document/d/1F8Q-7rmFXYjamTtqeTdXX20dgpQnIvHrCGJW3RIbtEw/edit?usp=sharing Privacy Policy: https://docs.google.com/document/d/1cK5q-VsOdZHvQAN_aE-3TDAXEeqlGANzR4aGS8WubnU/pub Terms and Conditions: https://docs.google.com/document/d/10PDMPFf25PsDadDhS02plUly3U8A2htbLEJOhkVYE-o/edit?usp=sharing

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New weight-loss drugs have transformed care for people with obesity. In this Clinical Reviews podcast, Robert F. Kushner, MD, MS, of Northwestern University Feinberg School of Medicine joins JAMA Deputy Editor Mary McGrae McDermott, MD, to discuss prescribing these drugs to improve health outcomes and minimize adverse effects in people with obesity. Related Content: Medications for Obesity https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.10816?utm_campaign=podcasts&utm_medium=social&utm_source=youtube&utm_content=public Podcast was originally published on July 22, 2024. https://edhub.ama-assn.org/jn-learning/audio-player/10.1001/jama.2024.13339?utm_campaign=podcasts&utm_medium=social&utm_source=youtube&utm_content=public --------------------------------------------------------------------------------- Follow JAMA Clinical Reviews on: Youtube: https://www.youtube.com/playlist?list=PL4VOPuLXRs1cP8cNKw0kuc358Wpfm03Lk Apple Podcasts: https://podcasts.apple.com/us/podcast/jama-clinical-reviews-interviews/id1027430378 Spotify: https://open.spotify.com/show/229VuDiWHzVc9S5OwBfLiY Pocket Casts: https://pca.st/3ghw Your podcast app of choice: https://pod.link/1027430378 Website: https://jamanetwork.com/journals/jama/pages/jama-clinical-reviews --------------------------------------------------------------------------------- For more from JAMA • https://www.jama.com • https://www.facebook.com/JAMAJournal • https://www.twitter.com/JAMA_Current • https://www.linkedin.com/company/jamanetwork Follow the JAMA Network • https://www.jamanetwork.com • http://www.jamanetworkaudio.com • https://www.facebook.com/JAMANetwork • https://www.twitter.com/JAMANetwork • https://www.instagram.com/JAMANetwork • https://www.pinterest.com/JAMANetwork

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Semaglutide, a medication that has been used for the treatment of type 2 diabetes, has garnered attention in recent years for its potential in aiding weight loss. The drug works by mimicking a hormone called glucagon-like peptide-1 (GLP-1) that regulates blood sugar levels and helps control appetite. This has led to speculation about whether Semaglutide could be used specifically for weight loss purposes. In this article, we will explore the current status of Semaglutide as a weight loss treatment.

Research on Semaglutide for Weight Loss

Several clinical trials have been conducted to investigate the efficacy of Semaglutide for weight loss in individuals who are overweight or obese. One of the most notable studies is the STEP program, which consists of four phase 3 trials that evaluated the effectiveness of Semaglutide compared to a placebo in promoting weight loss. The results have been promising, with participants receiving Semaglutide showing significantly greater weight loss compared to those on a placebo.

In one of the trials, participants who received Semaglutide lost an average of 15-20% of their body weight over a 68-week period. This is a significant amount of weight loss that could have a substantial impact on the health and well-being of individuals struggling with obesity. The results of these trials have led to increased excitement about the potential of Semaglutide as a weight loss treatment.

Furthermore, Semaglutide has also been shown to have other beneficial effects on metabolic health, such as improving blood sugar levels, reducing blood pressure, and lowering cholesterol. These additional benefits make Semaglutide a promising option for individuals who not only want to lose weight but also improve their overall health.

Approval Status of Semaglutide for Weight Loss

While Semaglutide has not yet been approved by the FDA specifically for weight loss, it is already FDA-approved for the treatment of type 2 diabetes. The success of the STEP trials has raised hopes that Semaglutide could eventually receive approval as a weight loss medication. Pharmaceutical companies are currently seeking approval from regulatory authorities for the use of Semaglutide as a weight loss treatment.

It is important to note that even though Semaglutide has shown promising results in clinical trials, it may not be suitable for everyone. Like any medication, Semaglutide can have side effects and contraindications that need to be considered. It is crucial for individuals considering Semaglutide for weight loss to discuss the risks and benefits with their healthcare provider before starting treatment.

In conclusion, while Semaglutide is not yet approved for weight loss, the results of clinical trials suggest that it could be a valuable tool in helping individuals achieve significant weight loss. With further research and regulatory approval, Semaglutide may soon become a mainstream option for those looking to improve their health through weight loss.

Potential Side Effects of Semaglutide

As with any medication, Semaglutide can potentially cause side effects in some individuals. Common side effects of Semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects usually subside over time as the body adjusts to the medication. In rare cases, Semaglutide can also lead to more serious side effects such as pancreatitis or kidney problems. It is essential to consult with a healthcare provider before starting Semaglutide to understand the potential risks and benefits.





Additionally, Semaglutide may interact with other medications or supplements that a person is taking. It is crucial to inform healthcare providers of any medications being used to prevent potential drug interactions. Pregnant or breastfeeding individuals should also consult with a healthcare provider before using Semaglutide, as its effects on pregnancy and breastfeeding are not fully understood.

Overall, while Semaglutide shows promise as a weight loss medication, individuals considering its use should be aware of the potential side effects and risks associated with the drug. Working closely with healthcare providers can help ensure that Semaglutide is used safely and effectively for weight loss purposes.

Cost and Accessibility of Semaglutide

One potential barrier to the widespread use of Semaglutide for weight loss is its cost. As a newer medication, Semaglutide may be expensive and not covered by all insurance plans. However, some pharmaceutical companies offer assistance programs or discounts to make Semaglutide more accessible to individuals who could benefit from it.

Accessibility can also be a concern, as Semaglutide may not be readily available in all regions or healthcare settings. Individuals interested in using Semaglutide for weight loss should inquire with their healthcare provider about the availability of the medication and any potential barriers to access. They may also consider participating in clinical trials or research studies to access Semaglutide at a reduced cost or for free.

Overall, while cost and accessibility may present challenges for some individuals, the potential benefits of Semaglutide for weight loss make it a compelling option for those struggling with obesity. With increased awareness and advocacy, Semaglutide could become more widely available and affordable for individuals seeking to improve their health through weight loss.

Long-term Effects and Considerations

Another important aspect to consider when using Semaglutide for weight loss is the long-term effects of the medication. While clinical trials have demonstrated significant weight loss in the short term, it is essential to understand how Semaglutide may impact health outcomes over an extended period. Research is ongoing to evaluate the long-term effects of Semaglutide on weight maintenance, metabolic health, and overall well-being.

Individuals using Semaglutide for weight loss should also be aware of the importance of lifestyle changes such as diet and exercise in conjunction with medication. Sustainable weight loss and improvements in health require a holistic approach that includes healthy habits and behaviors. Semaglutide can be a valuable tool in this process, but it is not a standalone solution.

In conclusion, while Semaglutide shows promise as a weight loss medication, individuals should be mindful of the long-term effects, lifestyle considerations, and overall health implications of using the drug. Working closely with healthcare providers and maintaining lifestyle changes can help ensure the safe and effective use of Semaglutide for weight loss and improved health outcomes.

As the research and development of Semaglutide for weight loss continue to progress, individuals may have questions about the medication and its potential benefits. Here are some frequently asked questions about Semaglutide as a weight loss treatment:

Frequently Asked Questions

Q: Is Semaglutide approved for weight loss?

A: Semaglutide is not currently approved for weight loss by regulatory authorities, but it is being studied for this purpose in clinical trials.

Q: What are the potential side effects of Semaglutide?

A: Common side effects of Semaglutide include nausea, vomiting, diarrhea, and constipation. In rare cases, it can also lead to pancreatitis or kidney problems.

Q: How does Semaglutide work for weight loss?

A: Semaglutide works by mimicking a hormone that helps control appetite and regulate blood sugar levels, leading to decreased food intake and weight loss.

Q: Is Semaglutide suitable for everyone?

A: Semaglutide may not be suitable for everyone, and individuals should consult with healthcare providers to determine if it is a safe and effective option for weight loss.

Q: What are the long-term effects of using Semaglutide for weight loss?

A: The long-term effects of Semaglutide for weight loss are still being studied, and it is essential for individuals to consider lifestyle changes and overall health implications when using the medication.

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