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Downsized Weekly Weigh In: Laraine and Christopher's Weight Loss Journey with GLP-1 Medications In this week's episode of Downsized Weekly Weigh In, hosts Laraine and Christopher Durham discuss their 70-week weight loss journey using GLP-1 medications such as Wegovy, Ozempic, Z Bound, Mounjaro, and compounded Tirzepatide. Laraine, who has lost over 50 pounds, shares her strategies for maintaining her weight, including her daily protein goals, calorie control, and varied exercise routines. Christopher also discusses his progress, setbacks, and eventual success in achieving near-goal weight post-cruise. They answer FAQs, touch on food choices, and delve into their views on obesity as a chronic disease and the long-term utility of GLP-1 medications. Additionally, they announce their Downsized at Sea cruise in June 2025 and discuss upcoming episodes and interviews, including an insightful conversation with Dr. Dan, an expert on the challenges faced by individuals with obesity. Viewers are encouraged to join their community, book the cruise, and benefit from various resources available on their website, theDownsized.org. We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. BOOK THE DOWNSIZED AT SEA CRUISE: https://thedownsized.org/downsized-at-sea-2025/ DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store 00:00 Introduction to Downsized Weekly Weigh In 00:27 Laraine's Weight Loss Journey 02:55 Weekly Weigh In Update 04:14 Maintaining Weight Loss and Diet Tips 09:54 Exercise Routine and Benefits 16:48 Christopher's Weight Loss Journey 18:22 Unexpected Weight Gain and Analysis 24:48 Upcoming Downsized at Sea Cruise 29:18 Conclusion and Upcoming Content

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Click Here to Subscribe: http://Bit.ly/ThomasVid Find Good Culture in Whole Foods: https://www.goodculture.com My Website: http://ThomasDeLauer.com Belly Fat | Top 5 Causes of Belly Fat for MEN [2019] (Fat Loss 101) 1) Not enough Salt and Glucocorticoids (cortisol) out of balance Salt & Cortisol: Low sodium levels cause an increase in aldosterone, an adrenal hormone that seeks to preserve sodium in the body when it’s perceived to be scarce - aldosterone is responsible for telling the kidneys to retain the salt that your body needs. In other words, a lack of sodium can cause the brain to send signals to the adrenal glands to increase the release of aldosterone, which is responsible for water balance - cortisol is released alongside aldosterone. Cortisol & Belly Fat: Tissue cortisol concentrations are controlled by a specific enzyme (11-hydroxysteroid dehydrogenase) that converts inactive cortisone to active cortisol. This particular enzyme is located in adipose tissues - the gene for this enzyme is expressed more by obese conditions and has also been demonstrated in research that human visceral fat cells have more of these enzymes compared to subcutaneous fat cells. Thus, higher levels of these enzymes in these deep fat cells surrounding the abdomen may lead to obesity due to greater amounts of cortisol being produced at the tissue level. Additionally, deep abdominal fat has four times more cortisol receptors compared to subcutaneous fat. Cortisol can increase the activity of lipoprotein lipase (LPL), the major fat storing enzyme - there’s more cortisol receptors in visceral fat, hence more LPL activity there. Study – Oncotarget: The randomized, open-label pilot trial was conducted at a single institution. A total of 85 obese people were enrolled. All participants were served meals three times a day, and provided either a low salt diet or control diet with same calorie. Reductions in body weight (–6.3% vs. –5.0%) and BMI (–6.6% vs. –5.1%) were greater in the low salt group than in the control group. Extracellular water and total body water were significantly reduced in the low salt group compared to the control group. However, changes in body fat mass, visceral fat area, and skeletal muscle mass did not differ between the two groups. The observed decrease of body weight was caused by reduction of total body water, not by reduction of body fat mass or visceral fat mass. https://www.ncbi.nlm.nih.gov/pmc/arti... 2) Cardio in a Fed State (benefits of fasted training in general) Fat Loss (Intramyocellular Lipids) & Muscle Growth (P70S6K) Study - The Journal of Physiology: Findings- During F but not during CHO, the exercise bout decreased IMTG content in type I fibres from roughly 18% to 6% area lipid staining. Exercise-induced net glycogen breakdown was similar in F and CHO - however, compared with CHO, mean rate of postexercise muscle glycogen resynthesis was 3-fold greater in F. https://www.ncbi.nlm.nih.gov/pmc/arti... Study - European Journal of Applied Physiology A study from the European Journal of Applied Physiology had subjects split into two groups that were trained on two occasions separated by three weeks - one of the sessions was performed on an empty stomach after an overnight fast. Found: Increased p70s6k phosphorylation during intake of a protein–carb drink following resistance exercise in the fasted state - fasted training group saw a bigger increase in p70s6k. https://link.springer.com/article/10.... 3) Sleep Deprivation - Metabolic Health Study - Public Library of Science: Medicine: In this study, subjects (1,024 ) who consistently slept less than five hours a night had significant differences in the hormones leptin and ghrelin as compared with people who slept an average of eight hours a night. More specifically, subjects suffering a lack of sleep had 16% less leptin and nearly 15% more ghrelin than those who were well rested did. https://www.ncbi.nlm.nih.gov/pmc/arti... Molecular Level (endocannabinoids) Lack of sleep increases activity of endocannabinoid 2-arachidonoylglycerol (2-AG), which is mediated via the CB1 receptor. https://www.ncbi.nlm.nih.gov/pubmed/2... 4) Too Much Fructose: After the 100:0 glucose bolus, fractional lipogenesis rose to only 8%, which is quite low compared with the 23% observed previously (32). After consumption of the 50:50 and 25:75 solutions used here, the peak in lipogenesis was 17%. Lipogenesis increased 2-fold when as little as half the glucose was replaced with fructose. https://academic.oup.com/jn/article/1... 5) Estrogen & Alcohol Study – Toxicology: The study looked to investigate if ethanol alters aromatization of androgens and concentrations of hepatic estrogen and androgen receptors. In rats given ethanol, hepatic aromatization of androgen to estrogen was significantly increased by the ethanol administration. https://www.ncbi.nlm.nih.gov/pubmed/2...

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FDA's Bold Move on Drug Approvals & Promising GLP-1 Research In this episode of Downsized News, hosts Laraine and Christopher Durham delve into the latest developments surrounding GLP-1 medications and their broader implications for obesity and related health issues. Key highlights include the FDA's ambitious plan to expedite drug approval times with the Commissioner's National Priority Voucher (CNPV) program, a significant court ruling favoring the FDA and Novo Nordisk on Semaglutide compounding, and promising research showing GLP-1's potential benefits for fibromyalgia sufferers. Moreover, updates on new drugs like DDO-1 and Dapaglutide, and emergent therapies such as Sana for fat burning and gene-editing treatments for cardiovascular disease, are discussed. The episode wraps up with perspectives on the ongoing policies potentially curbing drug advertisements and the notable phase-out of Saxenda in favor of more advanced medications like Wegovy. DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store As an Amazon Associate I earn from qualifying purchases. Join CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED WEBSITE: https://thedownsized.org/ FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Introduction and Welcome 01:07 FDA Ruling on Semaglutide Compounding 02:30 New FDA Pilot Program for Drug Approval 05:21 GLP-1s and Fibromyalgia Relief 08:45 New GLP-1 Drug from South Korea 12:28 Discontinuation of Saxenda in Australia 14:51 Zealand Pharma's Dapiglutide 17:02 Experimental Obesity Pill: Sana 21:26 Potential Ban on Drug Ads 24:57 Eli Lilly's Acquisition of Verve Therapeutics 28:01 Conclusion and Farewell

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