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Pasti pernah lihat TEMAN kalian yang LAGI MAU DIET kan?! KAYAK GINI NIH!! Diet apa diet?!!! Follow LDP on FACEBOOK! http://www.facebook.com/LastDayProd and INSTAGRAM! http://www.instagram.com/LastDayProd EMAIL: For business enquiries please contact [email protected] LIKE, SUBSCRIBE & BANTU SHARE YAAAA!!! :) CIRI² ORANG DIET Produced & Directed by: Leon Zhe Young (http://www.instagram.com/Elziwai) Listia Magdalena (http://www.instagram.com/tya_magdalena) Director of Photography: Dicky "Yong" Salim (http://www.instagram.com/yongnato) Line Producer: Jessica Prasetya (http://www.instagram.com/jazzpeee) Staff writer: Dicky "Yong" Salim (http://www.instagram.com/yongnato) Soundman: Ryan Boentoro (http://www.instagram.com/ryannboentoro) Translator: Peter Ticoalu (http://www.instagram.com/pete_tic) CAST: Leon Zhe Young (http://instagram.com/elziwai) Listia Magdalena (http://instagram.com/tya_magdalena) Reza Ferdian Sadha (http://instagram.com/rezafs) *** LASTDAY Production: Leon Zhe Young http://instagram.com/elziwai Listia Magdalena http://instagram.com/tya_magdalena --- Copyright 2016, LASTDAY Production.
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Gear, Growth, and Gains Ep. 014 Peptide Reconstitution Demystified, Emerging Data on Combined GLP-1 Agonists and Myostatin Inhibitors, Oral Steroids and the Heart, and Coach's Corner - Training Volume Myths Show Time 32 min, 26 sec Show Notes and Description In episode 14 of "Gear Growth and Gains," Type-IIx discusses evidence-based practices in enhanced bodybuilding. He debunks myths about peptide reconstitution, emphasizing normal saline as the optimal solvent. The episode reviews emerging clinical data on combining GLP-1 agonists with myostatin inhibitors for improved muscle retention during weight loss. Type-IIx explains why oral 17 alpha-alkylated steroids pose greater cardiovascular risks than injectables due to their effects on lipid metabolism. Finally, he clarifies that excessive training volume impairs hypertrophy, stressing the importance of quality, intensity, and recovery for muscle growth. Outline and Timestamps Introduction and Episode Overview (00:00:30) Type-IIx introduces the podcast, outlines the four main topics, and provides disclaimers and promotional info. Peptide Reconstitution: Myths and Best Practices (00:02:56) Explains misconceptions about peptide reconstitution, debunks bro science, and emphasizes normal saline as the best solvent. History of Bro Science in Peptide Use (00:04:07) Describes the origins of peptide reconstitution myths in early bodybuilding forums and how misinformation spread. NAD+ and Solvent Confusion (00:06:33) Discusses the rise of NAD+ injections, their ineffectiveness, and confusion about which solvents to use. Normal Saline vs. Bacteriostatic Water (00:08:02) Clarifies why normal saline is preferred for reconstitution, and addresses misconceptions about bacteriostatic water. Properties and Safety of Normal Saline (00:09:05) Explains what normal saline is, its isotonic properties, and why it’s safe and widely used. Risks of Bacteriostatic Water and Solvent Regulation (00:10:24) Compares the risks of homemade bacteriostatic water to normal saline and explains regulatory reasons. GLP-1 Agonists and Myostatin Inhibitors: New Data (00:11:32) Introduces the COURAGE trial and the rationale for combining GLP-1 agonists with trevogrumab. Strategies to Preserve Muscle on GLP-1 Drugs (00:12:38) Outlines three strategies to maintain muscle while using GLP-1 drugs, focusing on drug interventions. Myostatin Inhibitors: Mechanisms and Trials (00:13:48) Reviews the history, mechanisms, and clinical trials of myostatin inhibitors, including new combination therapies with trevogrumab. COURAGE Trial Results and Drug Synergy (00:14:59) Details the COURAGE trial’s experimental groups, results, and the synergy of combining the myostatin inhibitor trevogrumab with GLP-1 drugs. Molecular Pathways in Muscle Growth (00:15:59) Explains the molecular signaling pathways involved in muscle growth and how different drugs interact. Safety and Side Effects of Myostatin/Activin-A Inhibitors (00:16:14) Discusses the safety profile of new myostatin inhibitors like trevogrumab and the side effects of anti-activin A drugs. Oral Steroids and Cardiovascular Risk (00:17:31) Explains why 17 alpha-alkylated oral steroids like Anavar are more harmful to heart health than injectables. Mechanisms of Steroid-Induced Dyslipidemia (00:18:47) Describes how oral steroids negatively affect lipid profiles and increase cardiovascular risk. Estrogen’s Protective Role and Specific Steroid Effects (00:20:08) Covers the protective effects of estrogen on lipids and why certain steroids are harsher on the heart. Summary: Why Some Steroids Are Safer for Lipids (00:21:20) Summarizes why Dianabol is less harsh on lipids and why Trenbolone is still risky despite being injectable. Book Promotion: Bolus Guide (00:21:20) Promotes the Bolus guide for practical bodybuilding drug protocols and research interpretation. Bloodwork and Lab Testing Recommendations (00:23:07) Recommends Fitomics for blood work and explains how to sign up for lab testing and newsletters. Coach’s Corner: Training Volume Myths (00:24:10) Explains why more sets, reps, or sessions are not better for muscle growth and can be counterproductive. Mechanisms of Hypertrophy and Recovery (00:25:25) Discusses the science of muscle growth, the importance of recovery, and the difference between strength and size. Effective Reps and Optimal Training Volume (00:26:35) Emphasizes the importance of effective reps, diminishing returns of excessive volume, and the inverse dose-response curve. Conclusion and Outro (00:26:35) Wraps up the episode and promises more regular content in the future. Topics Gear Growth and Gains, Meso-Rx, enhanced bodybuilding, peptide reconstitution, peptides, broscience, normal saline, GLP-1, trevogrumab, GLP-1 agonists, myostatin inhibitors, Courage trial, semaglutide, muscle retention, fat loss, oral steroids, cardiovascular risk, 17 alpha-alkylated steroid...
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When you drink alcohol 🍷 , your body prioritizes metabolizing it over burning carbohydrates and fats. This means that as long as alcohol is in your system, fat-burning (and to some extent carb-burning) is put on hold. This can interfere with weight loss or body composition goals because the calories from alcohol are burned first, leaving the calories from fat and carbs to be stored rather than used for energy. How is this possible?🤔 Well, the calories from carbohydrates and fats that you consume are more likely to be stored rather than burned when you’re drinking. Specifically: Fat: Instead of being used for energy, dietary fat is more likely to be stored in fat cells when alcohol is present in the system. This can hinder fat loss efforts, as your body won’t burn fat as long as alcohol is still being metabolized. Carbohydrates: Similarly, carbohydrates that aren’t immediately needed for energy may be stored as glycogen or converted into fat if glycogen stores are full. If your body isn’t changing but you’re drinking every day 🚨NEWS FLASH 🚨 it’s definitely a contributing factor whether you want to admit it or not. Is it possible to have a healthy relationship with alcohol and still reach your goals? Probably. But alcohol has so many negative health benefits that honestly at the end of the day, you’re doing yourself a disservice by consuming it regularly. Medical study after medical study cites that there is no safe or “recommended” dose. DM me “transform “ to understand what FOOD to eat and when for the next 12 weeks so you can finally start reaching your goals and stop making excuses🤓
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Julia Fox blasted rumors that she is using Ozempic to maintain her thin frame. The always-candid “Uncut Gems” star said in a new interview that she would “never” take the drug, which is meant for people with diabetes, for weight loss because there are patients who genuinely need it to live. “All these people are coming for me saying that I take the weight-loss things — people are saying that I’m taking Ozempic or whatever it’s called — I’m not, and I never have,” Fox told “Entertainment Tonight” Sunday. Read more at https://pagesix.com/2023/03/20/julia-fox-blasts-rumors-shes-using-weight-loss-drug-ozempic/ #juliafox #ozempic Page Six is your source for celebrity news, gossip, entertainment, pop culture, photos, video and more. Catch the latest news and gossip here: https://pagesix.com/ Follow us on: Facebook - https://www.facebook.com/pagesix/ Twitter - https://twitter.com/PageSix Instagram - https://www.instagram.com/pagesix/ Check out We Hear, our Page Six podcast! https://podcasts.apple.com/us/podcast/we-hear/id1479076951 https://open.spotify.com/show/4A4v65sX7nIHpEtrYnInDm And Page Six Style has the latest news on celebrity style including fashion trends, red carpet photos, and beauty tips. Catch the latest news here: https://pagesix.com/style/ Follow us on: Facebook - https://www.facebook.com/pagesix/ Twitter - https://twitter.com/PageSix
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