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🥑 Make smarter food choices. Become a member at https://zoe.com Get 10% off membership with code PODCAST Forty percent of people in the UK and US have high cholesterol. Knowing how to lower it can be confusing. In today’s episode, we simplify the science of cholesterol, drawing from ZOE’s 2021 PREDICT study, which explored its link to the gut microbiome. Dr. Sarah Berry explains the differences between ‘good’ and ‘bad’ cholesterol, discusses how cholesterol can impact your health, and shares tips on maintaining healthy cholesterol levels. Sarah is a professor in the Department of Nutritional Sciences at King's College London and Chief Scientist at ZOE. She is also the lead nutritional scientist on the PREDICT program. 🌱 Try our new plant based wholefood supplement - Daily30: https://zoe.com/daily30?utm_medium=zoe_podcast&utm_source=podcast_platform&utm_campaign=d30 *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system Follow ZOE on Instagram: https://www.instagram.com/zoe/ Timecodes 00:00 Introduction 01:01 Quickfire questions 04:01 What is cholesterol? 05:57 LDL vs HDL cholesterol 12:28 How diet affects cholesterol 13:55 Which fats should you increase? 16:58 Why do some people have high LDL levels? 19:36 The gut microbiome and cholesterol 21:31 What is ApoB? 25:55 Why don’t all doctors measure ApoB? 28:10 Why triglycerides matter to your health 30:02 Triglycerides and post-meal responses 33:04 Which foods can lower cholesterol? 35:38 Saturated fat explained 37:49 How refined carbs affect cholesterol 41:57 Can you trust ‘low fat’ food labels? 43:21 The benefits of whole grain carbohydrates and fiber 47:11 Sarah’s personal view on statins 50:24 Cholesterol levels in postmenopausal women Books by our ZOE Scientists: Every Body Should Know This by Dr Federica Amati https://amzn.to/4blJsLg Food For Life by Prof. Tim Spector https://amzn.to/4amZinu Fibre Fuelled by Dr Will Bulsiewicz https://amzn.to/4bzmUXP Mentioned in today's episode: What are triglycerides and why do you need them https://zoe.com/learn/what-are-triglycerides Does variation in serum LDL-cholesterol response to dietary fatty acids help explain the controversy over fat quality and cardiovascular disease risk?, published in Atherosclerosis https://www.atherosclerosis-journal.com/article/S0021-9150(21)00145-3/abstract Determination of variability in serum low-density lipoprotein cholesterol response to the replacement of dietary saturated fat with unsaturated fat, Proceedings of the Nutrition Society. https://www.cambridge.org/core/journals/proceedings-of-the-nutrition-society/article/determination-of-variability-in-serum-low-density-lipoprotein-cholesterol-response-to-the-replacement-of-dietary-saturated-fat-with-unsaturated-fat-in-the-reading-imperial-surrey-saturated-fat-cholesterol-intervention-rissci-project/7E9C169FFEE58745111D45830798CA4B Dietary saturated fat and cholesterol: cracking the myths around eggs and cardiovascular disease, J Nutr Sci. 2023 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495817/ The effects of probiotics on total cholesterol, Medicine (Baltimore) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805418/ Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals (Zoe’s PREDICT study) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353542/ Have feedback or a topic you'd like us to cover? Let us know here: https://gf6hx47iu5g.typeform.com/topicsuggestion Episode transcripts are available: https://zoe.com/learn/category/podcasts

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Ketogenic therapy can be a powerful intervention for many people with mental illness, including those with serious conditions like bipolar disorder, schizophrenia and major depression. Initial data indicates that individual response to ketogenic therapy for mental health may vary. Research is ongoing and needs to further investigate underlying mechanisms and how metabolism impacts brain function in individual patients. While keto may not be an effective treatment for everyone, there are a number of ways patients can troubleshoot their ketogenic therapy strategy before deciding this treatment option doesn’t work for them. In this practical video, Dr. Bret Scher shares seven common reasons why ketogenic therapy may not be yielding results: - Ketone levels might not be high enough - The timeframe may not be long enough–for some patients, it can take up to 3-4 months to see optimum results All of these factors can also impair results: - Vitamin & nutrient deficiencies - Concurrent medical conditions - Abusing drugs and alcohol - Some medications make it harder to get into ketosis - Other lifestyle factors such as poor sleep or too much stress It is important to note that ketogenic therapy is more than simply following a keto diet. We recommend that anyone attempting to use a keto diet to treat a mental health condition work with a trained clinician. Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ More helpful resources related to this video: What is the difference between a keto diet and ketogenic therapy? - with Dr. Bret Scher: https://youtu.be/BK99A_bhn6Y Labs to Check Before Starting Ketosis for Mental Health: https://youtu.be/tSkOw3l8OoQ Find helpful resources, like how to find a clinician and the labs recommended for ketogenic therapy on this page of our website: https://www.metabolicmind.org/families-and-peers About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. Timestamps 0:00 Introduction 1:25 The difference between ketogenic therapy and a keto diet 2:09 How ketone levels impact ketogenic therapy 3:14 How time impacts ketogenic therapy 3:54 How vitamin and nutrient deficiencies impact ketogenic therapy 4:30 How concurrent conditions impact ketogenic therapy 4:46 How alcohol and drugs impact ketogenic therapy 5:18 How medications impact ketogenic therapy 6:10 How lifestyle factors impact ketogenic therapy 6:58 Conclusion #MetabolicMind #KetoForMentalHealth #MetabolicPsychiatry #MetabolicNeuroscience #KetogenicMetabolicTherapy #NutritionalKetosis #MentalIllness #AlternativeTreatment #KetoForDepression #KetoForBipolar #DepressionTreatment #MedicationSideEffects #MedicialKeto #KetogenicTherapy

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