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In this episode of the Pharm So Hard Podcast, the hosts discuss GLP-1 receptor agonists, a class of medications used to manage blood sugar levels in patients with type 2 diabetes and to treat obesity. They provide an overview of the history and development of GLP-1 receptor agonists, highlighting their clinical superiority and various benefits. The hosts also explain the role of GLP-1s in the body, including their glucose-dependent insulin secretion and effects on gastric emptying. They discuss the impact of GLP-1s on hunger and mental health, emphasizing the reduction of food noise and improvement in satiety levels. Additionally, they differentiate GLP-1 receptor agonists for diabetes and weight loss and explore their indications and guideline positioning. Takeaways • GLP-1 receptor agonists are a class of medications used to manage blood sugar levels in patients with type 2 diabetes and to treat obesity. • GLP-1 receptor agonists have shown clinical superiority to other anti-hyperglycemic drugs, improving glycemic control, reducing weight loss and blood pressure, and providing cardio-protective benefits. • GLP-1s increase glucose-dependent insulin secretion, block glucagon secretion, and slow gastric emptying, leading to improved blood sugar control and increased satiety. • GLP-1 receptor agonists have a positive impact on mental health, reducing food noise and helping individuals make healthier food choices. • Different GLP-1 receptor agonists have specific indications for diabetes and weight loss, and their use is guided by clinical guidelines. • GLP-1 receptor agonists are FDA-approved for improving glycemic control in patients with type 2 diabetes and for the treatment of obesity. • The choice of GLP-1 receptor agonist depends on factors such as comorbidities, weight loss goals, and patient preferences. • GLP-1 receptor agonists have different dosing regimens, and the specific dose may vary based on the indication and the product. • Common side effects of GLP-1 receptor agonists include nausea, vomiting, and diarrhea, but these side effects often improve with continued use and proper management. GLP-1 agonists can cause loss of appetite as a side effect. • GLP-1s are being used off-label for conditions such as NAFLD and depression. • GLP-1s may have positive effects on bone health and blood pressure. • The high cost of GLP-1s poses challenges for patient access. Chapters 00:00 Introduction to GLP-1 Receptor Agonists 01:12 History and Development of GLP-1 Receptor Agonists 06:14 The Role of GLP-1s in the Body 09:38 Effects of GLP-1s on Hunger and Mental Health 11:17 Differentiation of GLP-1 Receptor Agonists for Diabetes and Weight Loss 11:44 Indications and Guideline Positioning of GLP-1 Receptor Agonists

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Buy The Creators a Coffee 🥹: https://buymeacoffee.com/nbulai Obesity treatment is evolving—welcome to 2025, where groundbreaking medications are changing lives! Join us as we break down the science, results, and future of weight loss medications like tirzepatide, semaglutide, retatrutide, and orforglipron. These aren't just "diet pills"—they're transformative treatments targeting biological mechanisms that make weight loss sustainable. 🔗 Learn More: The references used to generate each podcast can be found at https://scicorn.nbulai.com or http://nbulai.com/podcast. 📅 Stay tuned for future episodes as we explore cutting-edge science and innovation. 🔥 In this episode, we explore: ✔️ How these medications mimic gut hormones to regulate appetite 🧠🍽️ ✔️ Clinical results, including retatrutide's stunning 24% weight loss, rivaling bariatric surgery 🏋️‍♀️ ✔️ The rise of oral options like orforglipron 💊 ✔️ Societal impacts: tackling obesity stigma and reshaping healthcare 🌍 ✔️ Challenges like cost, accessibility, and long-term efficacy 💸❗ 📖 Chapters/Timestamps: 0:00 - Introduction: Weight Loss Medications Revolutionizing 2025 🌟 0:27 - Not Just Diet Pills: How These Medications Work 🧠💊 1:22 - Semaglutide and Lifestyle Changes: Big Wins in Weight Loss 🏋️‍♀️🍽️ 1:49 - Tirzepatide: The Surprising Dual-Action Drug 💪✨ 2:17 - Retatrutide: Weight Loss Surgery Results Without Surgery 🚀🔥 3:16 - Orforglipron: The Pill Changing Accessibility 💊🆕 3:46 - Challenges: Cost, Access, and Long-Term Use 💸❗ 4:40 - Shifting the Stigma: Obesity as a Medical Condition 🫂⚕️ 5:39 - Public Health Policies: Insurance and Beyond 📜🏥 6:39 - The Future: Personalized Medicine and Triple Agonists 🔬🔮 8:00 - Beyond Medications: Bariatric Surgery in the New Landscape 🔧🏥 10:25 - Holistic Approaches: Behavior, Environment, and Society 🌍🍎 13:11 - The Gut Microbiome: A Frontier in Obesity Research 🦠🍽️ 15:27 - Behavior Changes: Small Goals, Big Results 🏃‍♀️🌟 18:35 - Barriers to Treatment: Stigma and Accessibility ⚖️❗ 21:30 - Societal Impact: Rethinking Health and Beauty Standards 🤔🌈 24:50 - A Compassionate Approach: Genetics, Behavior, and Care ❤️‍🩹🌍 28:42 - Final Thoughts: Hope for the Future of Obesity Treatment ✨🔮 🔔 Subscribe for More: If you’re fascinated by cutting-edge health science, don’t forget to LIKE, SUBSCRIBE, and hit the BELL ICON for weekly deep dives into groundbreaking research! #weightloss #obesity #personalizedmedicine #science2025 #2025 #scientificbreakthroughs #drugdiscovery #scientific #scientificrevolution #WeightLoss2025 #ObesityTreatment #ScienceExplained #WeightLossMedications #Tirzepatide #Semaglutide #Retatrutide #Orforglipron #HealthRevolution #FutureOfMedicine #podcast #sciencepodcast #scientifipodcast #scicorn #sciconpodcast #science #nbulai #nbulaipodcast #WeightLossJourney #WeightLossTransformation #WeightLossMotivation #WeightLossTips #BrainComputerInterfaces #ClimateChange #Metascience #EthicalInnovation #TheVisionaryOrb #HealthInnovation #CuttingEdgeScience #Breakthroughs #Innovation #Research

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11 Natural Therapies (Outside of Drugs And Surgery) That Actually Work [free checklist]: https://curtis-alexander.com/ Can taking metformin help you lose weight? The short answer is ... maybe. In the one study that most people point to they gave metformin to people who met the criteria for being overweight based on their body mass index (BMI). They also gave a placebo to the next group of people who met the same criteria and compared the two. I don't want to get into the specifics of the study but the bottom line is the group that got metformin did lose weight. The group that got the placebo gained weight. BUT - they didn't control for any other factors like changes in diet and exercise. They also found that the people that seemed to benefit the most were the heaviest and had the worst insulin resistance. To me - no matter how poorly designed this study was - this isn't a shocker. Pretty much anything you do for someone in that situation is going to help them. Improving insulin sensitivity is a great first step. So for these folks metformin will definitely help. The problem I have is that too many people are looking for a pill to help them lose weight. You can essentially do the same thing metformin is doing (improving insulin sensitivity) by: 1) Eating in a caloric deficit of 25% 2) Resistance training 3) Cutting out processed carbs Simple? Yes. And that's why it works.

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Ozempic And Wegovy: The Weight Loss Revolution Explained 👇 Watch The Video & Don’t Forget to Like, Comment, Subscribe, & Share The reason that anti-obesity medications seem like they are in the media every day now is because they are the first generation of medications that actually provide a significant amount of weight loss if you take them. On average, people lose about 15% of their body weight on one of the big name players and up to 20% on the other major medication. But individual results vary widely, somake sure to temper your expectations. #ObesityExplained #ScienceBasedHealth #ObesityPreventionTips #FitnessAndHealthTips #FamilyWellness #HealthEducationVideos #HealthyWeightManagement #MedicalWeightLossTips #ObesityEducation #CausesOfObesity #ObesitySolutions #HealthAndWellBeing #DrEvanNadler #ObesityInChildren #WeightManagement #EvidenceBasedHealth #HealthyLivingTips #FamilyHealth #ObesityAwareness #ChildhoodObesity #ParentingAndHealth #WeightLossScience #HealthyLifestyleChanges #NutritionEducation #PracticalHealthAdvice #ObesityInTeens

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A woman reacts to a comment about a weight loss drug being on back order, with the commenter mentioning they need it for diabetes. The video creator emphasizes support for everyone on their journey with the medication and suggests that if help is needed with a prescription, the commenter should ask directly, instead of being rude. The video includes a message about being supportive and encouraging, while also calling out the commenter for making what she interprets as tone-deaf statements.#weightlossjourney #diabetesawareness #support #medication #health

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