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Dr. Zachary Knight and Dr. Andrew Huberman discuss the development of GLP-1 drugs like Ozempic for diabetes and weight loss, examining their historical origins, biological mechanisms, and impact on appetite and metabolism. Dr. Zachary Knight is a professor of physiology at the University of California, San Francisco (UCSF), and Howard Hughes Medical Institute (HHMI) investigator. Dr. Andrew Huberman is a tenured professor of neurobiology and ophthalmology at Stanford University School of Medicine and host of the Huberman Lab podcast. Watch the full episode: https://youtu.be/C5KpIXjpzdY Show notes: https://www.hubermanlab.com/episode/dr-zachary-knight-the-science-of-hunger-medications-to-combat-obesity Timestamps 00:00 Introduction to Weight Loss Challenges 00:06 The Discovery of GLP-1 & Its Origins 01:35 Understanding the Incretin Effect 02:58 The Role of GLP-1 in Diabetes Treatment 04:39 Challenges & Innovations in GLP-1 Drug Development 05:52 Breakthroughs in GLP-1 Drugs for Weight Loss 10:47 Mechanisms of GLP-1 Drugs in the Brain 13:39 Conclusion & Further Insights #HubermanLab #Science #GLP1 Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

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Q: Can I take keto supplements if I’m not following a keto diet?

A: While keto supplements are specifically designed to support a ketogenic lifestyle, they can still be beneficial for those who aren’t following a strict keto diet. Many of the ingredients found in keto supplements, such as MCT oil and collagen peptides, offer numerous health benefits regardless of your dietary preferences.

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