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Learn about tirzepatide, the promising new medication for managing obesity. This video explains its unique mechanism of action, which mimics the effects of two hormones that regulate appetite and satiety, GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1). We will also provide an overview of the clinical trial results that demonstrated its effectiveness in promoting weight loss and improving overall health. Disclaimer: This YouTube channel is not intended to provide diagnosis, treatment, or medical advice. The content provided in this video is for informational purposes only. This should not be considered as a substitute for healthcare professional advice. Please consult a physician or other healthcare professional regarding any medical or health-related diagnosis or treatment options. The statements about specific products are not to diagnose, treat, cure, or prevent disease. References: 1. https://www.fda.gov/news-events/press-announcements/fda-approves-new-medication-chronic-weight-management 2. https://go.drugbank.com/drugs/DB15171 3. Farzam K, Patel P. Tirzepatide. [Updated 2024 Feb 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK585056/ 4. Chavda VP, Ajabiya J, Teli D, Bojarska J, Apostolopoulos V. Tirzepatide, a New Era of Dual-Targeted Treatment for Diabetes and Obesity: A Mini-Review. Molecules. 2022;27(13):4315. Published 2022 Jul 5. doi:10.3390/molecules27134315 5. Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., Wharton, S., Connery, L., Alves, B., ... & Stefanski, A. (2022). Tirzepatide once weekly for the treatment of obesity. New England Journal of Medicine, 387(3), 205-216. 6. Garvey WT, Frias JP, Jastreboff AM, le Roux CW, Sattar N, Aizenberg D, Mao H, Zhang S, Ahmad NN, Bunck MC, Benabbad I, Zhang XM; SURMOUNT-2 investigators. Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet. 2023 Aug 19;402(10402):613-626. doi: 10.1016/S0140-6736(23)01200-X. Epub 2023 Jun 26. PMID: 37385275. #zepbound #weightloss #loseweight #weightlossjourney #obesity #diet #fitness #health #tirzepatide #fdaapproved #antiobesitymedication

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Please Subscribe for 3-4x Videos per Week + Live Broadcasts! http://ThomasDeLauer.com Carb Burning vs. Fat Metabolism: Are You Burning Carbs or Fats? Thomas DeLauer… Aerobic vs Anaerobic Metabolism: As your body breaks down glucose, a simple sugar molecule, it produces a compound called pyruvate. When this compound enters the mitochondria, aerobic metabolism occurs in which this compound is oxidized and turned into carbon dioxide and water. In the case of anaerobic metabolism, pyruvate enters the fluid, or cytoplasm, of the cell and is turned into lactic acid via a process called glycolysis. Difference in Efficiency: When one glucose molecule is converted into lactic acid in anaerobic metabolism, three ATP molecules are generated; when a glucose molecule is converted into carbon dioxide and water via aerobic metabolism, it produces 39 molecules of ATP. However, glycolysis requires powerful enzymes that compensate for the lower energy efficiency of anaerobic metabolism - what limits the anaerobic process is the byproduct, or lactic acid. Aerobic vs Anaerobic Activities: If you’re performing a low-intensity physical activity over a long period of time, such as running a marathon, you’ll draw the majority of ATP from aerobic metabolism. For these types of activities, fat becomes the chief fuel source. Some activities require the use of both types of metabolism. For example, if you’re cycling in a long distance race, your body will draw on your anaerobic metabolism for a short-term energy boost to climb a hill (1) When Does Switch Occur: When your muscles do not have enough oxygen, such as when you're sprinting or otherwise exerting yourself in an extreme manner, your muscles must rely on anaerobic respiration. Your muscles cannot provide the energy they need to sustain your physical efforts given the amount of oxygen available - so when your body is lacking in oxygen, this is when the switch occurs. Crossover: The anaerobic threshold, also known as the lactate threshold, is the point where lactate (lactic acid) begins to accumulate in the bloodstream. The AT varies from person to person, and, within a given individual, sport to sport. Untrained individuals have a low AT (approximately 55 % of VO2 max), and elite endurance athletes, a high AT (approx. 80 - 90% of VO2 max) (2) Aerobic & Adult Hippocampal Neurogenesis: Study from researchers at the University of Jyvaskyla in Finland, published in the Journal of Physiology - Looked at how different types of physical exercise effects adult hippocampal neurogenesis. Found that sustained aerobic exercise had positive effects on brain structure and function, including on a process called adult hippocampal neurogenesis (AHN), which basically means nerve growth in the hippocampus (3) Aerobic & BDNF: Study - "Exercise Induces Hippocampal BDNF Through a PGC-1/FNDC5 Pathway," appeared in the journal Cell Metabolism. Researchers found that a molecule called FNDC5 and its byproduct, irisin, become elevated in the brain through endurance exercise - found that raising levels of irisin in the circulation caused the molecule to cross the blood brain barrier, which then increased the expression of BDNF and activated genes involved in cognition. Mice genetically altered to have low irisin levels in the brain had reduced levels of BDNF. (4) Additional: Researchers from New York University (NYU) Langone Medical Center published a study explaining why sustained aerobic exercise benefits the mammalian brain on a molecular level Concluded that, "Exercise Promotes the Expression of Brain Derived Neurotrophic Factor (BDNF) Through the Action of the Ketone Body β-Hydroxybutyrate.” (5) References: 1) What Is Aerobic & Anaerobic Metabolism? (2017, November 21). Retrieved from https://healthyliving.azcentral.com/aerobic-anaerobic-metabolism-14829.html 2) Anaerobic Threshold. (n.d.). Retrieved from http://www.rice.edu/~jenky/sports/anaerobic.threshold.html 3) Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained. (2016, February 24). Retrieved from http://onlinelibrary.wiley.com/doi/10.1113/JP271552/abstract 4) Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway - ScienceDirect. (n.d.). Retrieved from http://www.sciencedirect.com/science/article/pii/S155041311300377X 5) Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body ?-hydroxybutyrate. (2016, June 2). Retrieved from https://elifesciences.org/articles/15092

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Semaglutide, a medication initially developed to treat type 2 diabetes, has gained attention in recent years for its potential to aid in weight loss. With studies showing promising results in individuals struggling with obesity, many are turning to semaglutide as a solution to shedding excess pounds and improving overall health. One key aspect of using semaglutide for weight loss is understanding the maximum dose that can be safely and effectively administered.

Semaglutide Max Dose

Semaglutide is typically prescribed at a maximum dose of 2.4 mg per week for weight loss. This dose is significantly higher than the dosage used for managing type 2 diabetes. The higher dosage of semaglutide for weight loss is believed to have a greater impact on appetite suppression and metabolism, leading to more significant weight reduction results.

It is important to note that the maximum dose of semaglutide should only be determined and administered by a healthcare professional. Attempting to exceed the recommended dosage can lead to serious side effects and complications. Healthcare providers will take into account a variety of factors when determining the appropriate dose of semaglutide for weight loss, including the individual’s overall health, weight loss goals, and potential risks.

Potential Side Effects

As with any medication, there are potential side effects associated with the use of semaglutide for weight loss. Some common side effects may include nausea, vomiting, diarrhea, and constipation. These side effects are typically mild and may diminish over time as the body adjusts to the medication. However, it is essential to communicate any side effects to your healthcare provider to ensure they are manageable and do not pose a risk to your health.

In rare cases, more severe side effects such as pancreatitis or kidney problems may occur with the use of semaglutide. It is crucial to be aware of these potential risks and to seek medical attention immediately if you experience symptoms such as severe abdominal pain, persistent nausea or vomiting, or significant changes in urination.

Effectiveness and Considerations

Studies have shown that semaglutide can be an effective tool for weight loss when used in conjunction with a healthy diet and regular exercise. Individuals taking semaglutide for weight loss may experience significant reductions in body weight and improvements in metabolic markers such as blood sugar levels and cholesterol. It is essential to approach weight loss with semaglutide as part of a comprehensive plan that includes lifestyle modifications and ongoing support from healthcare providers.





Before beginning treatment with semaglutide for weight loss, it is important to discuss potential risks and benefits with your healthcare provider. While semaglutide shows promise in aiding weight loss efforts, it is not a one-size-fits-all solution. Your healthcare provider will work with you to assess your individual needs and determine if semaglutide is a suitable option for you.

Final Thoughts

In conclusion, semaglutide can be a valuable tool in the journey towards weight loss for individuals struggling with obesity. By understanding the maximum dose of semaglutide that can be safely administered and being aware of potential side effects and considerations, individuals can make informed decisions about incorporating semaglutide into their weight loss plan. With the guidance of healthcare professionals and a holistic approach to weight loss, semaglutide may offer significant benefits in achieving lasting weight loss and improved overall health.

Remember, weight loss is a complex process that requires dedication, patience, and support. Semaglutide may be a helpful addition to your weight loss journey, but it is essential to approach it as part of a comprehensive plan that takes into account all aspects of your health and well-being. With the right approach and support, achieving your weight loss goals with semaglutide is within reach.

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