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Partial or biased agonism to improve GLP-1 receptor agonist properties by Ben Jones, Clinical Senior Lecturer Imperial College London I will discuss our work aiming to understand whether the therapeutic properties and side effect profile of GLP-1R agonism can be improved by refining intracellular signalling properties. Ben Jones is a Clinical Senior Lecturer within the Section of Endocrinology and Investigative Medicine, and a Consultant in Metabolic Medicine based in Imperial College Healthcare NHS Trust and North West London Pathology. His research is focused on the translational pharmacology of G protein coupled receptors in metabolic disease. He completed his undergraduate medical training at the University of Cambridge in 2006, and was a Foundation and Core Medical trainee on the Cambridge and Oxford rotations, respectively. In 2010 he moved to Imperial as an Academic Clinical Fellow in Metabolic Medicine. He was awarded an MRC-funded Clinical Research Training Fellowship in 2013 (supervisors: Prof Steve Bloom and Prof Tricia Tan), during which he applied the emerging concept of "biased agonism" to the GLP-1 receptor. After completing clinical training in 2020 he has was awarded the Imperial Post-Doctoral, Post-CCT Fellowship (IPPRF), and subsequently an MRC Clinician Scientist Fellowship. Current work aims to establish the mechanism of action of “biased” incretin receptor agonists, and how their unusual effects can be exploited therapeutically in diabetes and obesity. https://thelongevityforum.com

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Sheryl Patrice Underwood (born October 28, 1963) is an American comedian, actress and television host. She first rose to prominence in the comedy world as the first female finalist in 1989's Miller Lite Comedy Search. Currently, Underwood is one of the hosts on the CBS Daytime talk show The Talk, a role she first stepped into in September 2011. Underwood was born in Little Rock, Arkansas, and later moved to Atwater, California, where she attended high school. She has a brother, Michael, and an older sister, Frankie, who was diagnosed with polio. Michael and Sheryl would often take turns giving care to Frankie. Sheryl is now Frankie's caregiver. Underwood revealed that she was born with a twin who did not survive. She went on to say that she had been lied to by her mother, who said that her father murdered her sister. Underwood admitted to carrying her sister's birth certificate around with her. She even stated that her mother stabbed her father, who survived, after Underwood had gotten close to her father, which her mother wanted to prevent after she lied to Underwood about her father being a murderer #CebeNews #SherylUnderwood #TheTalk Click to SUBSCRIBE for more awesome! https://www.youtube.com/channel/UCW16I-bXDMAMNtfsMf55fqA Thank you for stopping by the channel! If you enjoyed, I try to do videos every day! Check us out at: https://www.youtube.com/channel/UCW16I-bXDMAMNtfsMf55fqA

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💊 Can Ozempic (Semaglutide) Help You Lose Weight FAST? The TRUTH Revealed! 💊 Ozempic for weight loss has become a viral trend, but does it really work? In this video, we break down the science behind Semaglutide, how it burns fat, reduces appetite, and whether it's the best weight loss medication for you. Originally designed for type 2 diabetes, Ozempic has become one of the most talked-about weight loss drugs—but is it safe, and does the weight stay off? 🚨 WATCH THIS Before Taking Ozempic! 🚨 👉 In This Video, You’ll Learn: ✅ How Ozempic works for weight loss (GLP-1 mechanism explained) ✅ Ozempic vs. Wegovy vs. Mounjaro – Which is the best fat-loss drug? ✅ Ozempic side effects & risks – What you NEED to know ✅ Can you keep the weight off after stopping Ozempic? ✅ Is Ozempic a quick fix or a long-term solution? ✅ The TRUTH about Ozempic weight loss before and after results 🔬 This video is backed by science and provides an unbiased, expert-reviewed look at whether Semaglutide weight loss is a game-changer or just another trend. 💬 Have you tried Ozempic for weight loss? Share your experience in the comments! 🚀 LIKE, SUBSCRIBE, and hit the 🔔 BELL for more science-backed weight loss tips! 📌 More Weight Loss Videos: 🔹 The Best Diet for Weight Loss 🔹 Wegovy vs. Ozempic – What’s Better? 📖 Sources & Studies: (Include links to medical research or references mentioned in the video) #Ozempic #OzempicWeightLoss #Semaglutide #Wegovy #Mounjaro #WeightLossJourney #FatLoss #GLP1 #WeightLossTransformation #DiabetesMedication #LoseWeightFast #HealthTips

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최근 성공적인 다이어트로 몰라보게 달라진 MC 데프콘. 그도 늘 궁금했다던 다이어트 방법은 바로 GLP-1 기반 비만 치료제? 하지만 이 약의 작동 원리는 오랫동안 수수께끼로 남아있었는데... 이때 그 기전을 최초로 밝힌 사람이 등장했으니, 바로 의사 과학자 최형진! 심지어 그의 연구는 세계 3대 학술지 중 하나인 《사이언스》에 선정되기까지 했다는데..! 과연 그가 알아낸 GLP-1의 기전은 무엇이며, 우리 몸에서 살이 빠지는 원리는 무엇일까? GLP-1의 작동 원리부터 치명적인 약점까지 방송에서 전격 공개된다. “우리는 어떻게 배부름을 느끼는 것일까?” “디저트 배는 정말 따로 있을까?” 비만과 식욕에 대한 모든 궁금증에 답해줄 이른바 ’배부름 호르몬‘이라 불리는 GLP-1! 최형진은 생생한 실험 과정을 보여주며, 배부름과 식욕의 원리를 의학과 과학의 관점에서 흥미롭게 설명한다. 호기심을 한껏 자극하는 주제의 등장에 스튜디오는 초집중 상태에 달하는데. 과연 GLP-1은 인류의 끝없는 다이어트 전쟁을 종식시킬 수 있을까? GLP-1에 대한 사소한 궁금증부터 핵심 기전까지! 비만과 식욕, 그리고 호르몬의 숨겨진 원리. #EBS #알고e즘 #취미는과학 #과학 #비만 #비만치료제 #GLP-1 #다이어트 #데프콘 #최형진 #사이언스 #살 #식욕 #배부름 #호르몬 📺방송정보 📌프로그램명 : 취미는 과학 - GLP-1, 어떻게 비만 치료제가 되었나? 📌방송일자 : 2025년 2월 14일

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【99日目】 ------------------------------------------ 【2025年3月1日】体重：74.9kg 体脂肪率：16.9% ↓ 【2025年3月末】体重：72.1kg 体脂肪率：13.0% ↓ 【2025年4月末】体重：70.2kg 体脂肪率：11.8% ↓ 【2025年5月末】体重：67.0kg 体脂肪率：11.0% ------------------------------------------ 【目標】「ベストボディジャパンで優勝し、みんなに勇気を与える」【自分ルール】 ①仕事は最優先し、筋トレを言い訳にしない。 ②男らしさを追求する為に、筋トレに励む。 ③外見磨きだけでなく、心も鍛え抜く。 ④視聴者との信頼関係を大切にする。 ------------------------------------------ ※撮影してから、編集・投稿するまでにタイムラグ1日だけあります。

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Want to lose fat fast and achieve your weight loss goals? In this video, we'll share proven tips to help you burn belly fat, increase your metabolism, and get the body you've always wanted. From creating a calorie deficit to incorporating high-intensity interval training (HIIT) into your workout routine, we'll cover the most effective strategies to help you lose fat quickly and sustainably. Whether you're a beginner or a seasoned fitness enthusiast, these tips are sure to help you reach your goals and maintain a healthy weight for the long haul. So, what are you waiting for? Watch now and start losing fat faster today! 👍 Like, 🔔 Subscribe, and share with someone who needs this! #FatLoss #FitnessTips #WeightLoss #BurnFat #HIIT #FitnessJourney

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Are you following a ketogenic diet and looking for a convenient way to support your weight loss goals? If so, ViaKeto Gummies may be the perfect solution for you. These tasty gummies are packed with powerful ingredients that can help you stay on track with your keto lifestyle. In this article, we will explore the benefits of ViaKeto Gummies and why they are a must-have for keto enthusiasts.

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One of the main benefits of ViaKeto Gummies is their ability to support ketosis. Ketosis is a metabolic state in which your body burns fat for energy instead of carbohydrates. By following a ketogenic diet, you can enter ketosis and start burning stored fat for fuel. However, reaching and maintaining ketosis can be challenging, especially in the beginning stages of the diet. ViaKeto Gummies contain exogenous ketones, which can help your body enter ketosis more quickly and stay there longer.

In addition to supporting ketosis, ViaKeto Gummies can also help boost your energy levels. Many people experience a decrease in energy when first starting a ketogenic diet, as their bodies adjust to using fat for fuel instead of carbs. The exogenous ketones in ViaKeto Gummies can provide a quick and sustained source of energy, helping you feel more alert and focused throughout the day.

Furthermore, ViaKeto Gummies are a convenient and delicious way to supplement your keto diet. Instead of taking multiple pills or powders, you can simply enjoy a few gummies each day to get the nutrients you need. Plus, the gummies come in a variety of flavors, making them a tasty treat that you’ll look forward to eating.

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If you’re interested in trying ViaKeto Gummies, it’s important to know how to incorporate them into your daily routine for maximum effectiveness. The recommended dosage is to take two gummies per day, preferably with a meal. This will help your body absorb the nutrients more efficiently and support your ketosis goals.

In addition to taking ViaKeto Gummies daily, it’s also important to continue following a healthy ketogenic diet. While the gummies can help support your ketosis efforts, they are not a substitute for a balanced diet rich in whole foods. Be sure to focus on consuming high-quality fats, moderate protein, and low-carb vegetables to help your body stay in ketosis and burn fat for fuel.

Lastly, it’s important to stay hydrated while taking ViaKeto Gummies. Drinking plenty of water can help flush out toxins from your body and support overall health. Aim to drink at least eight glasses of water per day, or more if you’re exercising or living in a hot climate. Staying hydrated can also help prevent side effects such as constipation, which can sometimes occur when following a ketogenic diet.

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If you’re ready to try ViaKeto Gummies for yourself, you may be wondering where to purchase them. These gummies are available for purchase online through the official ViaKeto website. Simply visit the website, select the package size that best fits your needs, and complete your order. Your gummies will be shipped directly to your door, making it easy and convenient to start incorporating them into your daily routine.

Overall, ViaKeto Gummies are a must-have for keto enthusiasts looking to support their weight loss goals and maintain ketosis. With their powerful ingredients and delicious flavors, these gummies can help you stay on track with your keto lifestyle and feel your best. Give them a try today and see the difference they can make in your journey towards better health and wellness.

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Q: Are ViaKeto Gummies safe to take?

A: Yes, ViaKeto Gummies are made with natural ingredients and are safe for most people to take. However, if you have any underlying health conditions or are pregnant or nursing, it’s always best to consult with your healthcare provider before starting any new supplement.

Q: How long does it take to see results with ViaKeto Gummies?

A: Results can vary from person to person, but many users report experiencing increased energy and improved focus within a few days of taking ViaKeto Gummies. For best results, it’s recommended to take the gummies consistently and follow a healthy ketogenic diet.

Q: Can I take ViaKeto Gummies if I’m not following a ketogenic diet?

A: While ViaKeto Gummies are specifically formulated to support a ketogenic diet, you can still benefit from their ingredients even if you’re not strictly following a keto lifestyle. The exogenous ketones in the gummies can still help boost your energy levels and support weight loss, even if you occasionally consume carbs.

Q: Are there any side effects of taking ViaKeto Gummies?

A: Most people do not experience any side effects when taking ViaKeto Gummies. However, some users may experience minor digestive issues such as bloating or gas, especially if they are not used to consuming exogenous ketones. To minimize any potential side effects, start with a lower dose and gradually increase as needed.

Q: Can I take more than the recommended dosage of ViaKeto Gummies for faster results?

A: It’s not recommended to exceed the recommended dosage of ViaKeto Gummies, as doing so may not provide additional benefits and could potentially lead to unwanted side effects. Stick to the recommended two gummies per day, taken with a meal, for optimal results.