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Even as we prioritize natural interventions in functional medicine, GLP-1 agonist drugs such as Wegovy and Ozempic offer sometimes life-changing support for those who have long struggled with resistant overweight/obesity and high blood sugar. However, there are side effects, including the risk of substantial muscle loss and sagging, aged skin ("Ozempic face" as it's indelicately known). It's a concern that hits home for me, considering the pivotal role we know that muscle plays in overall health and longevity. In this New Frontiers podcast episode I welcome back Dr. Anurag Singh to unravel the complexities of these issues. We explore the interplay between metabolic health and muscle preservation, touching on everything from the mechanisms of GLP-1 agonists and their long-term effects on aging and sarcopenia, to the promising potential of dietary and lifestyle interventions to counteract negative effects. We consider the potential for one of my all-time fave postbiotic epinutrients - Urolithin A - to assist by supporting mitochondrial health and preserving/enhancing muscle quality. This timely conversation is one you won't want to miss. Tune in and please leave us a review wherever you listen to New Frontiers. – DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources. *Guest information* Anurag Singh, MD, PhD Chief Medical Officer at Timeline *Thank you to our sponsor* Timeline: https://tinyurl.com/4npjcvjf Mitopure: https://tinyurl.com/ypfjws2e Research from Timeline: https://tinyurl.com/53p6yjc9 [email protected] *Timeline Discount for New Frontiers Listeners* Timeline is offering Dr. Fitzgerald’s readers a 10% discount on Timeline products. Head on over to https://tinyurl.com/ypfjws2e and use the code KARA10 at the checkout. *Show Notes* Study: Once-Weekly Semaglutide in Adults with Overweight or Obesity: https://tinyurl.com/y3c2ypkw Pre-clinical trial (Recruiting): Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55= Years Old: A Randomized Triple-Masked Controlled Clinical Trial - https://https://tinyurl.com/bdzfccr8 Study: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults - https://tinyurl.com/2p9pjpxc Study: Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance - https://tinyurl.com/2jkhmu9w Study: Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis - https://tinyurl.com/mvrjxxsm Study: Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial - https://tinyurl.com/fscfdd85 Study: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans - https://tinyurl.com/mr2hd4ms Study: Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population - https://tinyurl.com/e6npdvyp Preprint article: Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials - https://tinyurl.com/2m2nzd56 Preclinical trial: Effects of Mitopure (Urolithin A) on Skeletal Muscle Function, Iron Metabolism and Endurance Performance (ENDURO) - https://tinyurl.com/nhkw2pvc Study: The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome - PubMed (nih.gov) - https://tinyurl.com/mrkk33e5 Study: Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice | PLOS Biology - https://tinyurl.com/3s38vtau Study: Urolithin A production drives the effects of pomegranate on the gut microbial metabolism of bile acids and cholesterol in mild dyslipidaemic overweight and obese individuals - PubMed (nih.gov) - https://tinyurl.com/wdzk3tx7 *DrKF Resources* FxMed Podcast: Beyond Mitochondrial Health: Can Urolithin A Slow Down Aging? - https://tinyurl.com/svzahswu DrKF Blog: Beyond Beauty: Targeting Skin Longevity with Urolithin A - https://tinyurl.com/5n6zfu9s DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Bio Age Lab Test: https://tinyurl.com/b7bjmfj9 Bio Age Self Assessment Quiz: https://tinyurl.com/4z8f7ucc Younger You Group Program: https://tinyurl.com/4hvusavw Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

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These are the three most common fat loss myths men over 35 fall for and need to stop believing now. Work with me 👉 https://bit.ly/Coach-Adam Free Fat Loss course 👉 bit.ly/Free-Nutrition-Course Get my course 👉 https://bit.ly/Learn-Nutrition If you’re over 35 and struggling with fat loss—especially stubborn belly fat—you’ve probably been fed a lot of bad advice. Maybe you’ve been told your metabolism is slowing down, that low testosterone is to blame, or that carbs are the reason you can’t lose weight. In this video, I break down 3 of the most common fat loss myths that keep men stuck, frustrated, and spinning their wheels. You’ll learn what’s actually going on with your body, and what to do instead to finally start losing fat and keeping it off. No gimmicks, no hype—just real, practical strategies to help you get leaner, stronger, and in control again. Studies: https://journals.lww.com/nsca-jscr/fulltext/2011/02000/short_term_heavy_resistance_training_eliminates.6.aspx https://link.springer.com/article/10.1007/s00421-012-2466-x https://www.sciencedirect.com/science/article/pii/S0531556519307806?via%3Dihub https://journals.physiology.org/doi/full/10.1152/ajpheart.00010.2021 https://www.nature.com/articles/s41366-024-01591-7#:~:text=For%20each%201%20kg%20of,for%20menopausal%20status%20in%20females. https://diabetesjournals.org/diabetes/article/58/12/2741/23632/Low-Fat-Versus-Low-Carbohydrate-Weight-Reduction https://jamanetwork.com/journals/jama/fullarticle/2673150 ------------------------------------------------------------------------------------------------------------------------ **DISCLAIMER** The information in this video is merely the opinion of me based on my research and studies. The research and information covered in this video is open to public domain for discussion and in no way breaches or breaks the boundaries of the law in the United Kingdom where I live. I am not a doctor, nor do I claim to have any formal medical background. I am not liable, either expressly or in an implied manner, nor claim any responsibility for any emotional or physical problems that may occur directly or indirectly from watching this video! ------------------------------------------------------------------------------------------------------------------------ Timestamps & Chapters: 0:00 – Intro 0:10 – Myth #1: Your Metabolism Slows Down After 35 3:00 – Myth #3: Low Testosterone Is Why You’re Gaining Fat 5:35 –  Myth #3: Insulin Is Making You Fat 7:50 – Bringing it all together 9:06–  Bonus Q&A: Your Fat Loss Questions Answered 12:14 – Final Thoughts + What to Do Next #fatlossmyths #fatloss #fatlossover35

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Watch the full episode and view show notes here: http://bit.ly/3Tap47T Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ In this “Ask Me Anything” (AMA) episode, Peter focuses the discussion on two topics getting a lot of attention recently. He first dives deep into GLP-1 agonists, most notably semaglutide and tirzepatide, which originally came to market as diabetes drugs but are now being studied and prescribed for weight loss. He walks through the data and compares the effectiveness of the two drugs, the side effects, and perhaps more importantly, his reservations around wide use of these drugs and who he would consider to be a candidate for them. Next, Peter discusses how metformin, another drug originally brought to market for diabetes management, gained popularity as a potential longevity drug even for non-diabetics. Peter gives his take on this possibility and reviews data from a more recent study investigating the question of whether metformin should be used for general “geroprotection.” In this sneak peek, we discuss: 00:00 - Intro 00:08 - The hype around semaglutide, tirzepatide, and other GLP-1 agonists for weight loss 04:09 - Overview of GLP-1 agonists and why these drugs are getting so much attention 12:20 - Defining the term “geroprotective” 14:08 - Semaglutide: background, brand names, indications, and more 19:10 - Tirzepatide: background, brand names, indications, and more In the full episode, we also discuss: -How semaglutide and tirzepatide compare in their efficacy in terms of weight loss and other metabolic health metrics; -Data showing sustained weight loss and improved metabolic metrics with after more than a year of using semaglutide and tirzepatide; -What happens to body weight when a patient discontinues the medication?; -Noteworthy side effects of GLP-1 agonists and similar classes of drugs; -Increased resting heart rate and other concerning trends in patients using GLP-1 agonists; -Changes in body composition (body fat and lean muscle) in patients on GLP-1 agonists; -Possible reasons for the loss of lean muscle mass and tips for protecting lean mass; -GLP-1 agonists and thyroid cancer; -Who might be a candidate for GLP-1 agonists?; -The large financial cost of this class of drugs; -Metformin as a geroprotective drug: origin of the idea that metformin could be a longevity agent even for non-diabetic patients; -A 2022 study on metformin sheds more light on the question of whether metformin should be used for “geroprotection” in non-diabetics; -Peter’s current approach with metformin for his patients; and -More. -------- About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 45 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://peterattiamd.com Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies.

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🚫 Stop making these fat loss mistakes that are keeping you from achieving your goals! Let's talk about what NOT to do if you're a man over 35 and want to drop body fat and build lean muscle (and actually keep it off): 1️⃣ Extreme Dieting & Carb Deprivation: * Lowers testosterone * Kills your energy and focus * Makes you crave unhealthy foods 2️⃣ Chasing Gimmicks & Fad Diets: * Leads to short-term results and long-term frustration * Disrupts your metabolism * Wastes your time and money 3️⃣ Excessive Cardio & Long Workouts: * Elevates cortisol (stress hormone) * Can lead to muscle loss * Increases risk of injury 💡 What actually works for men 35+: ✅ Strategic Nutrition: Eating for your goals and lifestyle, not restrictive dieting. ✅ Consistent Training: Focusing on compound exercises and progressive overload. ✅ Prioritizing Recovery: Getting enough sleep and managing stress. Ready to finally get the results you deserve without the frustration? Comment “BURN” for my free guide on sustainable fat loss and muscle building for busy men over 35! ♦️Subscribe ♦️ #workoutroutine #motivation #loseweight #exercise #fitnesscoach #homeworkout #leanmuscle #mensfitness #fitness #fitdad #calisthenics #bodyweightworkout #workout #fitover40 #strengthtraining #bodyweight #bodyweighttraining #bodyweightexercises #homefitness #calisthenics #loseweight #buildleanmuscle #fitover35 #health #fitnessgoals #burnfat #hiit #fitnesstips #fatlose #workoutmotivation #fatlosstips

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