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After just a few years on the market, a new wave of GLP-1 drugs approved for weight loss have upended what we know about obesity. By now, these are household names: Mounjaro. Wegovy. Zepbound… and yes, Ozempic. A Kaiser Family Foundation poll found that one in 8 American adults reported trying a GLP-1 medication (https://www.kff.org/health-costs/poll-finding/kff-health-tracking-poll-may-2024-the-publics-use-and-views-of-glp-1-drugs/) . “Body by Ozempic” has become a punchline on red carpets. Doctors and regulators have a strong body of evidence that GLP-1 drugs are remarkably effective at promoting weight loss and controlling diabetes. But new research looking at millions of patients in the VA medical system (https://theconversation.com/ozempic-and-similar-weight-loss-drugs-may-lower-risk-of-42-health-conditions-but-also-pose-risks-244243) has suggested they may have surprising effects on a range of other medical conditions – from cognitive diseases like Alzheimer’s to substance use disorder. The new data also found possible side effects that were not previously known. Soundside spoke with Dr. David Cummings, professor of medicine in the Division of Metabolism, Endocrinology and Nutrition at the University of Washington, about recent data dives into the widespread use of GLP-1 medications, and what those studies tell us about how we can rethink obesity. Guests: • Dr. David Cummings, professor of medicine in the Division of Metabolism, Endocrinology and Nutrition at the University of Washington. Related Links: • Sweeping review suggests weight-loss drugs’ effect on 175 conditions - The Washington Post (https://www.washingtonpost.com/health/2025/01/20/weight-loss-drugs-ozempic-wegovy-health-effects/) • End of the Line for BMI? Experts Propose New Obesity Definition - Newsweek (https://www.newsweek.com/end-bmi-experts-propose-new-obesity-definition-2015654) • Most people quit Ozempic within one year. Here's why. (https://www.usatoday.com/story/money/2025/02/02/why-people-quit-ozempic-within-one-year/78085106007/) Thank you to the supporters of KUOW, you help make this show possible! If you want to help out, go to kuow.org/donate/soundsidenotes (http://kuow.org/donate/soundsidenotes) Soundside is a production of KUOW in Seattle, a proud member of the NPR Network. See omnystudio.com/listener (https://omnystudio.com/listener) for privacy information.

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In this video, I explore the latest research on the psychological effects of GLP-1 receptor agonists — the medications that are transforming weight loss and type 2 diabetes care. As someone who uses these medications myself, I’m diving into both the potential mental health risks (like depression, anxiety, and mood changes) and the possible benefits (like improved emotional well-being and reduced binge eating behaviors). 🧠 Topics I cover include: • The link between GLP-1 drugs and depression/anxiety • What recent studies from the NIH and Diabetes, Obesity and Metabolism journal reveal • The obesity-depression connection • Possible neuroprotective effects of GLP-1 meds • Why results vary and the importance of a personalized approach If you're on Ozempic, Wegovy, Zepbound, or Mounjaro — or considering them — this video gives you a balanced look at what current science is saying about mental health side effects. 📢 Have you experienced any mental or emotional changes while on a GLP-1 medication? Share your story in the comments — let’s start a real conversation. For a great way to share information with other GLP-1 users, join my FaceBook group, Beyond the Scale | GLP-1 Support Community - https://www.facebook.com/groups/1956909991816723 ============================================ What I'm using to monitor & support my health: ============================================ My scale - https://amzn.to/3EbqrA6 My blood pressure monitor - https://amzn.to/4icEnaN FitIndex Bluetooth Body Measuring Tape - https://amzn.to/4ltjUkO Millies Steepable Broth Bags - https://amzn.to/4lxPuOy Vital Proteins Collagen Peptides - https://amzn.to/42Atx8N Nature's Truth Ultra Collagen Grass Fed Peptides - https://amzn.to/4ctih2s This video is not sponsored. Some product links are affiliate links meaning, if you buy something I may receive a small commission. Disclaimer: The content shared in this video is based on my personal experience with Zepbound (semaglutide/tirzepatide). I am not a medical professional, and the information provided here is for informational purposes only. Always consult with a healthcare provider before starting any new medication or treatment. Results and side effects can vary from person to person. 🔗 Resources Mentioned in the Video: • NIH study on semaglutide and mood changes – https://pmc.ncbi.nlm.nih.gov/articles/PMC11208009/ #GLP1Medications #Ozempic #Wegovy #Mounjaro #Zepbound #GLP1 #GLP1Therapy #WeightLossMedications #DiabetesTreatment #MetabolicHealth #MentalHealthAwareness #DepressionSupport #AnxietyAwareness #MentalHealthMatters #MoodHealth #MindBodyConnection #PsychologicalWellness

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