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@doctorstotrust http://www.DoctorsToTrust.com presents episode 2205 | DR BEN BIKMAN Dr Ben Bikman's dissertation work done in first GLP-1 lab in gastric-bypass procedures--as guts were re-plumbed, led to profound differences in GLP-1 -many gut hormones were changed with this surgery -GLP-1 is a natural hormone made by intestines Endocrine organs: thyroid, adrenals, gonads Brain , heart, muscle, bone makes hormones GLP-1 agonist: drug that, when injected, dials up GLP-1 signal to a superphysiological level… -early on in this drug testing, the dose was low, and it: -only inhibited glucagon [opposite effect of insulin] -quick and substantial drop in blood glucose -resolving T2D quite well -and, as little side effect, people ate a little less Now: at 5X dose: used as weight loss drug: Paralysis of the Intestines--main action -food stays in stomach 24+ hours GLP-1 is a metabolic advantage...we want it -protein intake will increase it; fat intake will increase it -some carbs do; so does fiber [stimulate L cells that make it] Can take advantage of GLP-1's satiety effect due to slowing down digestion Problem with these drugs: Slows Down Digestion Too Much -in some cases: permanent paralysis of intestines -must get nutrition thru infusion Rest of Life -and have colostomy bag |||||||||||||||||||||||||||||||| doctorstotrust.com healthresults.com insuliniq.com hlthcode.com original video interview: https://youtu.be/_krZOM4Zc3c?si=5agpNIgP4qg_Cnm- We will never use corruptible, epidemiological survey research as causal science. For each short/sharable video, the original Youtube links are provided above. None of this content is intended to be individual, personalized medical advice. We hope you find value for yourself in these videos & find them easy to share with loved ones! DISCLAIMER The DoctorsToTrust videos are for general informational purposes only and do not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.

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My Dear ones... Welcome to SAMANWAYAM #weightloss #dietfood #weightloss #protienbreakfast #dietbreakfast For a healthy diet and weight loss I prefer the below type of breakfast ,....................... Half of plates Fruits and vegetables Eat more! You don't often hear that when you have diabetes, but non-starchy vegetables are one food group where you can satisfy your appetite. Vegetables are full of vitamins, minerals, fiber and phytochemicals—and with so few calories and carbohydrate, everyone can enjoy more! There are two main types of vegetables—starchy and non-starchy. For this section, we are going to focus only on the non-starchy vegetables. For good health, try to eat at least six servings of vegetables a day. A serving of vegetables is: ½ cup of cooked vegetables 1 cup of raw vegetables Advertisement Common non-starchy vegetables The following is a list of common non-starchy vegetables: Chinese spinach Asparagus Baby corn Bamboo shoots Beans (green, wax, Italian) Bean sprout Broccoli Cabbage (green, bok choy, Chinese) Carrots Cauliflower Celery Cucumber Eggplant Mushrooms Onions Pea pods Peppers Radishes Salad greens Sprouts Tomato Turnips Fill half your plate with non-starchy vegetables like spinach, cucumbers, onions, and cabbage. Starchy vegetables like beans, peas, and lentils are also good, but should take up less of your plate. Fruits are also great, and can replace high-fat or high-sugar snacks. Low carb, high protein diets restrict the consumption of carbohydrates while promoting the consumption of proteins. This type of diet may help weight loss and muscle building, but may also carry health risks. Protein, carbohydrates, and fats are macronutrients. These nutrients are necessary in large quantities to provide a person with energy and keep them healthy. It is important for a person to have a balanced diet and consume sufficient amounts of each macronutrient. However, if a person is looking to lose weight or alter their body composition, they may wish to adjust the balance of macronutrients and consume more protein while reducing their carbohydrate intake. Protein is a major component of the skin, muscles, bones, organs, hair, and nails. Carbohydrates (carbs) act as one of the body’s main energy sources and can be either simple or complex. Dairy Choose fat-free or low-fat dairy, including milk, yogurt, cheese, or fortified soy products. Healthy oils Use healthy oils, such as olive oil. Coffee The caffeine in coffee can boost metabolism and fat breakdown. To maximize the health benefits, avoid adding large amounts of cream and sugar. Limit added sugar Eating a lot of added sugar is linked with some of the world's leading diseases, including heart disease, type 2 diabetes, and cancer. Advantages of high protein low carb diet Weight loss: Maintain weight loss: Body Composition: Blood Sugar: Heart Disease: Bone health: . Risks of a low carb, high protein diet Adopting a low carb, high protein diet may pose certain risks. For example, a diet that is high in protein can putTrusted Source acid load on the kidneys, which may increase a person’s risk of developing kidney disease. bone disorders increased cancer risks problems with liver function coronary artery disease Protein Eat protein at every meal, including lean meats like chicken, seafood, eggs, beans and peas, nuts, seeds, and soy products. Foods to include People following a low carb, high protein diet can include the following foods in their meals: eggs fish and shellfish meat poultry certain dairy nonstarchy vegetables seeds soy mycoprotein kefir almonds, almond butter, and almond milk peanuts and peanut butter pistachios chickpeas- Low-fat cottage cheese, greek yogurt, and low-fat milk are all viable options. Foods filled with healthy fat (e.g., avocados, nut butter, olive oil, fatty fish) contribute to weight loss because they make you feel full. Healthy, unsaturated fats boost heart health Healthy carbs are chockful of nutrients They’re good for the brain, kidney function, central nervous system, and heart What foods help you lose fat and maintain muscle? Foods to Build Muscle and Lose Fat Chicken. Turkybreast. Fish. Tofu. Eggs. Salmon. Greek Yogurt. While losing weight you don’t have to lose muscle. Be intentional with your exercise plan and diet as you build muscle while losing fat. Here are ten foods you can add to your diet to support your protein intake. Chicken Turkey breast Fish Tofu Eggs Salmon Greek Yogurt Edamame Quinoa Brown rice How can I lose weight and get fit at 45? If you're new to fitness, start slowly and don't overdo it. ... Be sure to incorporate strength training. ... Eat more protein—and veggies. ... Consider meal timing. ... Eat slowly and mindfully. ... Try to reduce stress and prioritise sleep. ... Stay hydrated. ...

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Today, we’re talking about a fascinating topic that has been generating buzz in both the peptide and medical and wellness communities: microdosing GLP-1 agonists for overall health. In this episode, we'll explore how this emerging practice could impact metabolic health, weight management, and even longevity. Let’s break down what we know and what it could mean for you. What Are GLP-1 Agonists? Before we get into the idea of microdosing, let’s first understand what GLP-1 agonists are. GLP-1 stands for glucagon-like peptide-1. It’s a peptide hormone that plays a major role in regulating blood sugar levels and appetite. GLP-1 is found in many different areas of the body including the intestine, pancreas, and central nervous system. It’s also found in the hypothalamus. GLP-1 agonists, like semaglutide (brand names Ozempic and Wegovy), are peptides that mimic this natural hormone. They're typically used for managing type 2 diabetes and, more recently, for weight loss. These peptides work by enhancing insulin secretion when glucose levels are elevated, slowing down gastric emptying, and reducing appetite. They also help lower blood pressure and stabilize blood sugar and cholesterol levels. Most recently they’ve been approved for improving cardiovascular health. What is Microdosing? Microdosing, in the context of GLP-1 agonists, refers to taking very small, sub-therapeutic doses of the peptide, typically much lower than those used in the treatment of diabetes or obesity. These smaller doses could potentially have a subtle impact on your metabolic heath, appetite, and overall well-being without causing the more intense side effects seen at higher doses. Why Microdose GLP-1 Agonists? I want to highlight several potential benefits of microdosing GLP-1 agonists for overall health, even for people who aren’t dealing with obesity or type 2 diabetes. Improved Blood Sugar Regulation: GLP-1 agonists are known to help regulate blood sugar levels by enhancing insulin sensitivity. Microdosing could help prevent insulin resistance, a condition that often leads to chronic diseases like type 2 diabetes. Even if you’re not diabetic, stabilizing blood sugar can help improve energy levels, reduce cravings, and support better metabolic health. Weight Management and Improved Satiety: One of the most well-known effects of GLP-1 agonists at higher doses is weight loss. Microdosing might help with weight management by subtly decreasing appetite and promoting more stable blood sugar levels, which could reduce those energy crashes and sugar cravings that often lead to overeating. For some people, microdosing could provide a gentle nudge toward more balanced eating habits and may help individuals manage emotional eating triggered by stress or fluctuating hunger signals. Potential Longevity Benefits: The positive effects on insulin sensitivity, blood sugar, and body composition aren’t just about feeling good in the moment. There is also a potential long-term benefit of microdosing GLP-1 agonists, especially when it comes to longevity. Since insulin resistance and poor metabolic health are linked to aging, chronic disease, and even shorter life expectancy, using these peptides in low doses could theoretically help slow down some of these age-related processes. Reduced Inflammation: Chronic low-grade inflammation is a key contributor to many health issues, from cardiovascular disease to autoimmune conditions. Some studies have suggested that GLP-1 agonists may have anti-inflammatory effects, which could contribute to overall better health. Microdosing may help reduce systemic inflammation without the significant side effects that come with higher doses. When it comes to microdosing GLP-1 agonists, it’s important to start slow and work with a healthcare professional to tailor the dosing to your unique needs and goals (a more individualized approach). But it’s important to keep in mind that while microdosing GLP-1 agonists is generally considered safe, there can be side effects, such as nausea or digestive discomfort, especially if the dose is not carefully monitored. That's why it's essential to start with a very low dose and gradually increase it under the guidance of a healthcare provider. What Does Microdosing GLP-1 Look Like in Practice? The specific dosing will depend on the individual, but in general, a "microdose" of semaglutide would be much lower than the typical prescribed dose for managing diabetes or obesity. For example, the typical starting dose for weight loss with semaglutide is 0.25 mg per week whereas a microdose might involve starting at a fraction of that amount. An example of a microdosing schedule might look like: Week 1-4: 0.025 mg to 0.05 mg once a week (roughly 1/10th to 1/5th of the initial standard dose). Week 5-8: 0.05 mg to 0.1 mg once a week. Beyond Week 8: Gradual increase (if...

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Over a quarter of the Indian adult population is either obese, at risk of diabetes or are diabetic. This has become a marketing & business opportunity for a lot of fitness & healthtech companies with plain vanilla no science interventions focussed on either high protein, calorie counting, CGM driven or at worst GLP-1 drugs. But these companies fail to understand how human biochemistry works. These interventions, if they help in weight loss, is a stop gap arrangement. Weight gain is not the cause but the effect & symptom. Obesity is triggered by low grade chronic inflammation & our body tries its best to maintain a metabolic homeostasis. However, regular insults we do to our body by consuming toxins or ingesting those foods that are transformed by your microbiome into toxins or pro-inflammatory metabolites makes it hard for us to lose weight. Some of these metabolites include LPS, TMAO, P-cresol & more. While microbes living in our mouth & gut also produce certain beneficial metabolites & incretin hormones ( providing we are feeding them with the right food substrates) that maintain our metabolic health & make it hard for us to gain weight. One of the most important metabolites ( incretin hormone) is GLP-1. Yes, our body automatically produces GLP-1 by synthesising fibre & polyphenols in the food we eat. GLP-1 has multiple benefits via regulating various metabolic pathways-regulates blood sugar response, communicates with brain via gut-brain axis , telling that you are full & even tells stomach & intestine to slow the movement of digestive tract. However, these GLP-1 drugs which lot of companies claim mimics natural GLP-1 brings multiple side effects & just ingesting these drugs does not mean it will help you lose weight. -Effectiveness of GLP-1 drugs depends upon the functions of your microbiome. Certain microbes can synthesise these drugs into beneficial stuff that have positive correlation with glycemic reduction while some others if active & expressing virulence genes can interfere with synthesis of GLP-1 drugs . -Certain microbes if active & expressing virulence genes can degrade GLP-1, making you gain weight or develop type 2 diabetes. In such scenario, these drugs cannot help. -It has been found that obese have underexpressed NOS attributed to overexpression of tumour necrosis factor-α caused by microbial derived endotoxin LPS. Besides, there are multiple other factors that can suppress NOS/cause endothelial cell dysfunction such as overexpression of ADMA, oxidative stress( caused by P-cresol &/or Indoxyl Sulphate Production), TMAO & more. In order to understand the root cause of obesity, there is a need to understand multiple molecular pathways that trigger its onset/progression. We at Genefitletics measures these pathways to construct nutritional therapeutics interventions aligned with your biochemistry that reinstates yout metabolic homeostasis Citations https://pmc.ncbi.nlm.nih.gov/articles/PMC4112002/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7021470/ https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14725 https://pmc.ncbi.nlm.nih.gov/articles/PMC10391832/ https://diabetesjournals.org/care/article/33/2/453/27096/GLP-1-Based-Therapy-for-Diabetes-What-You-Do-Not https://pmc.ncbi.nlm.nih.gov/articles/PMC5082693/ #obesity #obesityfreeindia #obesityfreenation #obesityawareness #viralvideo #virlshort #viralreels #viral_video #viralshorts #viralnews #healthnews #healthtips #health #healthylifestyle #supplements #obesitymedicine #obesityprevention #obesityawareness #type2diabetes #diabetesawareness #diabetesmanagement #diabetescare #diabetescure

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Dr. DeVincentis, or Dr. D. as his patients call him, uses non-invasive technology through a procedure called i-Lipo.

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