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Pull up a chair and join the Three Apothecaries around the fire as we wrap up the year with a lively chat featuring friends and colleagues Clare Howard and Jonathan Underhill. Together, we reflect on an exciting and dramatic year in the ever-changing world of healthcare and medicines. From groundbreaking developments like weight-loss drugs and debates around assisted dying to critical issues such as polypharmacy and exploring new career paths, we dive into the stories that shaped 2024—and how they’ve impacted us personally and professionally.On a lighter note, What does the weight of the British National Formulary reveal about the history of medicines? What drink smells like a pharmacy? And how measuring Prostate Specific Antigen can be fun! For this episode’s micro discussion, we travel back 60 years to explore the 1964 classic, "Patient's View of Admission to a London Teaching Hospital." This fascinating study sheds light on how patient experiences have evolved—and in some cases, stayed the same—over the decades. (Read the paper (https://pubmed.ncbi.nlm.nih.gov/14171095/) ) This year has been one for the record books, with the Three Apothecaries travelling to Bordeaux and performing for a sell-out audience in Cardiff. We’re so grateful to our incredible guests and loyal listeners for making it another unforgettable year of stories, conversations, and medicines-related fun.Merry Christmas and Happy New Year! Check out our website www.theauralapothecary.com (https://www.theauralapothecary.com)  for a searchable database of all episodes, blogs and bonus content for your enjoyment and education.To get in touch and interact follow us on Blue Sky @auralapothecary.pharmsky.app , Twitter @auralapothecary or email us at [email protected] . Don’t forget to rate us and comment wherever you have got this podcast from.  You can listen to the Aural Apothecary playlist here; https://open.spotify.com/playlist/3OsWj4w8sxsvuwR9zMXgn5?si=tiHXrQI7QsGtSQwPyz1KBg  You can view the Aural Apothecary Library here;   (https://about) https://litalist.com/shelf/view-bookcase?publicId=KN6E3O

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Some people follow a ketogenic diet seeking to lose weight, feel more energised, or gain control over their eating habits. Others may turn to this diet in an effort to treat their epilepsy, bipolar disorder, or diabetes. Regardless of their reasoning for adopting this eating pattern, a key question remains: can high LDL cholesterol levels on a ketogenic diet be safe? In Episode #311, I’m joined by Dr William Cromwell, MD and Dave Feldman to explore this question. :point_down: Visit The Proof website for the full show notes and supporting studies. :point_down: https://theproof.com/podcast/ Dr William Cromwell is a lipidologist with over 35 years of clinical practice experience. Since 1990, Dr Cromwell’s practice has specialised in managing lipid and lipoprotein disorders. He has authored over two dozen peer-reviewed papers and book chapters on evaluating and managing lipoprotein disorders and lipoprotein analytics. Dave Feldman is a software and platform engineer, an entrepreneur, and founder of the Citizen Science Foundation. His life took a radical turn on seeing his cholesterol skyrocket after adopting a ketogenic diet, leading him to research lipidology. Through a series of self-experiments and partnering with formal researchers, he has since published the "Lipid Energy Model" which may explain this phenomenon. Connect with Dr William Cromwell: - Twitter/X (personal): /lipoprotein - Twitter/X (Precision Health Reports): / precisehlthrpt - LinkedIn (personal): /wcromwellmd - LinkedIn (Precision Health Reports): / precisionhealthreports - Facebook: / precisionhealthreports - Instagram: / precisehlthrpt - Website (personal): https://www.mylipid.com/ - Website (Precision Health Reports): https://precisionhealthreports.com/ Connect with Dave Feldman: - Twitter/X: / realdavefeldman - YouTube: / @realdavefeldman - Instagram: / realdavefeldman - Citizen Science Foundation: https://citizensciencefoundation.org/ - Own Your Labs: https://ownyourlabs.com/ - Cholesterol Code: https://cholesterolcode.com/ We covered: 00:00 Intro 01:54 Dr. William Cromwell: Background as a Lipidologist and LDL Research 05:34 Dave Feldman's Ketogenic Diet and Elevated LDL Experience 12:30 Unpacking the Lipid Hypothesis and Cardiovascular Risk 20:40 The history and evolution of the lipid hypothesis 23:39 The role of apoB lipoproteins in atherosclerosis 31:59 Factors beyond apoB involved in atherosclerosis and mortality risk 41:43 The complexity of interpreting mortality data in the context of apoB 44:00 Macrophages and the process of atherosclerosis 52:57 Beyond ApoB: Metabolic Vulnerability, Inflammation and Mortality Risk 1:10:35 Transcytosis: A New Perspective on LDL Movement and Atherosclerosis 1:17:33 Exploring Low Cholesterol Impacts and Genetic Disorders 1:22:30 Macrophage Function and Phenotype Across Different ApoB Drivers 1:31:41 Defining Lean Mass Hyper Responders in the Context of a Ketogenic Diet 1:38:00 Investigating PCSK9 and Its Effects on Healthspan 1:44:18 Assessing cardiovascular risk in lean mass hyper-responders 2:02:19 Statin safety, adverse effects, and patient reluctance 2:11:10 Ketogenic Diets and Elevated LDL: Risks and Benefits in the Absence of Long-Term Data 2:18:40 Insulin Resistance, ApoB, and Cardiovascular Risk: Challenges in Assessment and Imaging 2:33:06 Lean Mass Hyper-Responder Study: Design, Recruitment, and Eligibility Criteria 3:05:15 Outro Enjoy, friends. Simon This episode is brought to you by: InsideTracker If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon http://insidetracker.com/simon. Shopify Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at http://shopify.com/proof Sun Home Saunas Invest in your body and mind with Sun Home Saunas, pioneers in crafting premium saunas and cold plunges. Safe, effective, research-backed wellness tools to improve cardiovascular health, offer psychological benefits, and reduce muscle soreness. Head to http://sunhomesaunas.com/theproof for $300 off your purchase. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com http://eimele.com/ and use code SIMON at checkout for 10% off your first order. Simon Hill, MSc, BSc (Hons) Creator of http://theproof.com/ and host of The Proof with Simon Hill https://theproof.com/podcast/ Author of The Proof is in the Plants https://theproof.com/book/

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