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. Chapters 0:00 Introduction 0:10 Ketosis and keto diet 1:52 Types of ketosis diet 2:45 Tests and symptoms of ketosis 3:06 Keto diet food plan 3:56 Foods to avoid in keto The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate mainstream dietary therapy that in medicine is used mainly to treat hard-to-control (refractory) epilepsy in children. The diet forces the body to burn fats rather than carbohydrates. Normally carbohydrates in food are converted into glucose, which is then transported around the body and is important in fueling brain function. However, if only a little carbohydrate remains in the diet, the liver converts fat into fatty acids and ketone bodies, the latter passing into the brain and replacing glucose as an energy source. An elevated level of ketone bodies in the blood (a state called ketosis) eventually lowers the frequency of epileptic seizures.[1] Around half of children and young people with epilepsy who have tried some form of this diet saw the number of seizures drop by at least half, and the effect persists after discontinuing the diet.[2] Some evidence shows that adults with epilepsy may benefit from the diet and that a less strict regimen, such as a modified Atkins diet, is similarly effective.[1] Side effects may include constipation, high cholesterol, growth slowing, acidosis, and kidney stones.[3] The original therapeutic diet for paediatric epilepsy provides just enough protein for body growth and repair, and sufficient calories[Note 1] to maintain the correct weight for age and height. The classic therapeutic ketogenic diet was developed for treatment of paediatric epilepsy in the 1920s and was widely used into the next decade, but its popularity waned with the introduction of effective anticonvulsant medications. This classic ketogenic diet contains a 4:1 ketogenic ratio or ratio by weight of fat to combined protein and carbohydrate. This is achieved by excluding high-carbohydrate foods such as starchy fruits and vegetables, bread, pasta, grains, and sugar, while increasing the consumption of foods high in fat such as nuts, cream, and butter.[1] Most dietary fat is made of molecules called long-chain triglycerides (LCTs). However, medium-chain triglycerides (MCTs)—made from fatty acids with shorter carbon chains than LCTs—are more ketogenic. A variant of the classic diet known as the MCT ketogenic diet uses a form of coconut oil, which is rich in MCTs, to provide around half the calories. As less overall fat is needed in this variant of the diet, a greater proportion of carbohydrate and protein can be consumed, allowing a greater variety of food choices.[4][5] In 1994, Hollywood producer Jim Abrahams, whose son's severe epilepsy was effectively controlled by the diet, created the Charlie Foundation for Ketogenic Therapies to further promote diet therapy. Publicity included an appearance on NBC's Dateline program and ...First Do No Harm (1997), a made-for-television film starring Meryl Streep. The foundation sponsored a research study, the results of which—announced in 1996—marked the beginning of renewed scientific interest in the diet.[1] Possible therapeutic uses for the ketogenic diet have been studied for many additional neurological disorders, some of which include: Alzheimer's disease, amyotrophic lateral sclerosis, headache, neurotrauma, pain, Parkinson's disease, and sleep disorders.[6]

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Semaglutide is a medication that has been gaining attention recently for its ability to contribute to weight loss in individuals struggling with obesity. This drug was originally developed to help manage type 2 diabetes, but researchers have discovered that it also has significant effects on weight loss. Understanding how semaglutide works and its potential benefits can provide valuable insights for individuals looking to achieve their weight loss goals.

1. Mechanism of Action

Semaglutide belongs to a class of medications known as glucagon-like peptide-1 receptor agonists. These drugs work by mimicking the effects of a naturally occurring hormone called GLP-1. GLP-1 plays a crucial role in regulating blood sugar levels and appetite. When semaglutide is introduced into the body, it activates GLP-1 receptors, leading to increased insulin production, decreased glucagon secretion, and delayed gastric emptying. These effects help to lower blood sugar levels, reduce hunger, and promote feelings of fullness.

Additionally, semaglutide has been shown to have direct effects on the brain that suppress appetite and reduce food intake. By targeting the areas of the brain involved in hunger and satiety, semaglutide can help individuals eat less and make healthier food choices, ultimately leading to weight loss.

Overall, semaglutide works through a combination of mechanisms to promote weight loss. By targeting both physiological and psychological factors that contribute to obesity, semaglutide can provide a comprehensive approach to managing weight and improving overall health.

2. Clinical Studies

Multiple clinical studies have been conducted to evaluate the efficacy of semaglutide for weight loss. One of the most notable trials is the STEP program, which consisted of four phase 3 trials involving over 4,500 participants. In these studies, participants were treated with once-weekly injections of semaglutide at various doses ranging from 0.05 to 2.4 mg.

The results of these trials were impressive, with participants experiencing significant weight loss compared to those treated with a placebo. In some cases, individuals taking semaglutide lost up to 15% of their body weight, making it one of the most effective weight loss medications available. These findings have led to the approval of semaglutide by the FDA for chronic weight management in individuals with obesity or overweight.

Furthermore, studies have shown that semaglutide not only helps individuals lose weight but also improves other metabolic parameters, such as blood pressure, cholesterol levels, and markers of inflammation. This indicates that semaglutide may have broader benefits beyond weight loss and could potentially help reduce the risk of developing obesity-related diseases.

3. Side Effects and Considerations

While semaglutide has shown promising results for weight loss, it is important to be aware of potential side effects and considerations when using this medication. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These symptoms usually improve over time as the body adjusts to the medication, but some individuals may find them challenging to manage.

Additionally, there have been concerns about the risk of pancreatitis and thyroid tumors associated with semaglutide. It is essential to discuss any pre-existing medical conditions or concerns with your healthcare provider before starting treatment with semaglutide. Regular monitoring and follow-up appointments are recommended to ensure the safe and effective use of this medication.

Overall, while semaglutide can be a valuable tool for weight loss, it is essential to approach its use with caution and under the guidance of a healthcare professional. By understanding the potential risks and benefits of semaglutide, individuals can make informed decisions about incorporating this medication into their weight loss journey.

4. Practical Considerations

When considering semaglutide for weight loss, there are several practical considerations to keep in mind. Semaglutide is typically administered as a once-weekly injection, which may require some adjustment to your daily routine. It is essential to follow the prescribed dosing schedule and administration instructions provided by your healthcare provider to ensure the effectiveness of the medication.

Additionally, it is essential to combine semaglutide treatment with healthy lifestyle changes, such as diet and exercise, to maximize weight loss outcomes. While semaglutide can help control appetite and promote weight loss, sustainable results are more likely to be achieved through a holistic approach that includes healthy eating habits and regular physical activity.

Regular monitoring and follow-up appointments with your healthcare provider are crucial to track your progress and make any necessary adjustments to your treatment plan. Open communication with your healthcare provider can help ensure the safe and effective use of semaglutide for weight loss.

5. Future Implications

As we continue to learn more about the potential benefits of semaglutide for weight loss, there are exciting possibilities for the future of obesity management. Ongoing research and clinical trials are exploring new formulations and dosing strategies for semaglutide that may further enhance its effectiveness.

Additionally, researchers are investigating the use of semaglutide in combination with other weight loss medications or therapies to provide a more comprehensive approach to obesity treatment. By leveraging the unique mechanisms of action of semaglutide and combining it with other interventions, we may be able to address obesity from multiple angles and improve outcomes for individuals struggling with weight management.

Overall, the development of semaglutide as a weight loss medication represents a significant advancement in the field of obesity management. By harnessing the power of this innovative drug, we have the potential to revolutionize the way we approach weight loss and improve the lives of individuals affected by obesity.

Summary and FAQ

In summary, semaglutide is a medication that can contribute to weight loss by targeting multiple physiological and psychological factors involved in obesity. Through its mechanisms of action, clinical studies have shown that semaglutide can lead to significant weight loss and improvements in metabolic health. However, it is essential to consider potential side effects and practical considerations when using this medication for weight management.

For individuals considering semaglutide for weight loss, it is crucial to consult with a healthcare provider to determine if this medication is right for you. By discussing your goals, concerns, and medical history with your healthcare provider, you can make an informed decision about incorporating semaglutide into your weight loss journey. Remember that sustainable weight loss is best achieved through a holistic approach that includes healthy lifestyle habits and regular monitoring of your progress.

If you have any questions or concerns about semaglutide and its role in weight loss, don’t hesitate to speak with your healthcare provider. They can provide personalized guidance and support to help you navigate the challenges of weight management and achieve your health goals. With the right resources and support, you can make meaningful changes to your health and well-being with the help of semaglutide.

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