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@East-Bound's personal recount of case: https://youtu.be/7BpymtR2vpA @East-Bound Interview: https://youtu.be/o15HCjtSkug @chubbyemu video on this case: https://youtu.be/ChPeG19qKUo @HemeReview Podcast version: https://anchor.fm/chubbyemu 2,4-Dinitrophenol (DNP) is a chemical that is not approved for weight loss in the United States. It is a classic case of efficacy, but without safety in the setting of weight loss. This setting of weight loss can be prone to chemical misuse, further exacerbating understanding in human systems. Christopher is one of 2 - 3 cases documented in literature to have survived an accident with DNP for weight loss. As of 2021, one organization has permission from the US FDA to investigate DNP in some neurodegenerative disorders. These are rare diseases with limited standards of care, therefore extenuating circumstances to find anything that could potentially improve patient outcomes. Tweet me: https://www.twitter.com/hemereview IG me: https://www.instagram.com/hemereview FB me: https://www.facebook.com/hemereview References: Role of dantrolene in dinitrophenol (DNP) : A continuing question? Am J Emerg Med. 2019 Jun;37(6):1216.e1-1216.e2. https://pubmed.ncbi.nlm.nih.gov/30948257/ 2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity . J Med Toxicol. 2011 Sep;7(3):205-12. https://pubmed.ncbi.nlm.nih.gov/21739343/ Ambient temperature and mortality from unintentional . JAMA. 1998 Jun 10;279(22):1795-800. https://pubmed.ncbi.nlm.nih.gov/9628710/ Dinitrophenol as a Medicine. Cells. 2019 Mar; 8(3): 280. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468406/ The Interaction of Highly Active Uncouplers With Mitochondria. Biochimica et Biophysica Acta, 639 (1981) 225-242. Beware the yellow slimming pill: fatal 2,4-dinitrophenol. BMJ Case Rep. 2016 Apr 4;2016. https://pubmed.ncbi.nlm.nih.gov/27045052/ Dantrolene is not the answer to 2,4-dinitrophenol poisoning: more heated debate. BMJ Case Rep. 2018 Dec 19;11(1):e225323. https://pubmed.ncbi.nlm.nih.gov/30573533/ The effect of 2,4-dinitrophenol on adipose-tissue metabolism. Biochem J. 1969 Feb;111(4):431-44. https://pubmed.ncbi.nlm.nih.gov/4388239/ The mechanism of uncoupling of oxidative phosphorylation by 2,4-dinitrophenol. J Biol Chem. 1967 Oct 25;242(20):4577-83. https://pubmed.ncbi.nlm.nih.gov/4964808/ MECHANISMS OF DINITROPHENOL TOXICITY. Simon E.W. Biological Reviews. Vol 28. (4). Nov 1953. Identification and Importance of Brown Adipose Tissue in Adult Humans. https://www.nejm.org/doi/full/10.1056/NEJMoa0810780 Mitochondrial uncoupling as a target for drug development for the treatment of obesity. Obes Rev. 2001 Nov;2(4):255-65. https://pubmed.ncbi.nlm.nih.gov/12119996/ LC-MS-MS analysis of 2,4-dinitrophenol and its phase I and II metabolites. J Ana Toxicol. Jan-Feb 2007;31(1):55-61. https://pubmed.ncbi.nlm.nih.gov/17389084/ Uncouplers of oxidative phosphorylation. Environ Health Perspect. 1990 Jul;87:213-8. https://pubmed.ncbi.nlm.nih.gov/2176586/ Texas Woman Charged with Selling Misbranded https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/press-releases/texas-woman-charged-selling-misbranded-drug

Starting Keto The Right Way A Beginner's Guide To Fat Burning

– Fasted cardio isnt the reason youre losing fat. Its the calorie deficit. Thats it. The people getting real results are the ones lifting consistently, eating enough protein, and sticking to the plan long enough for it to work. Keep it simple. No hacks. Just habits.

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The ketogenic diet has gained immense popularity in recent years for its potential health benefits and weight loss advantages. One of the key elements of the keto diet is the state of ketosis, where the body burns fat for fuel instead of carbohydrates. To support individuals in achieving and maintaining ketosis, supplements like Keto Flow have become increasingly popular.

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Keto Flow is a dietary supplement specifically formulated to help people following a ketogenic diet. It contains a blend of exogenous ketones that can help increase ketone levels in the body, making it easier to enter and stay in ketosis. By providing an additional source of ketones, Keto Flow can help improve energy levels, enhance mental clarity, and support fat loss.

Benefits of Keto Flow

1. Increased Energy Levels: When the body is in ketosis, it burns fat for fuel instead of glucose, which can lead to a steadier supply of energy throughout the day. By supplementing with Keto Flow, individuals may experience a boost in energy levels, making it easier to power through workouts or stay focused at work.

2. Enhanced Mental Clarity: Many people report improved mental clarity and focus when following a ketogenic diet. The ketones produced during ketosis are thought to provide a more stable source of energy for the brain, which can lead to increased mental clarity and cognitive function. Keto Flow can help support this benefit by providing additional exogenous ketones.

3. Appetite Suppression: One of the challenges of any diet is managing hunger and cravings. The keto diet is known for its appetite-suppressing effects, and Keto Flow can further support this by helping to stabilize blood sugar levels and reduce carb cravings. This can make it easier to stick to a ketogenic meal plan and achieve weight loss goals.

How to Use Keto Flow

1. Start Slowly: If you are new to taking exogenous ketones, it’s a good idea to start slowly to allow your body to adjust. Begin with a smaller dose of Keto Flow and gradually increase as needed to achieve the desired effects.

2. Take with Water: To ensure optimal absorption, it’s recommended to take Keto Flow with a full glass of water. This can help the exogenous ketones dissolve quickly in the stomach and enter the bloodstream more efficiently.

3. Use as Needed: Some people may choose to take Keto Flow daily to support ketosis, while others may prefer to use it as needed for an extra boost of energy or to help get back into ketosis after a carb-rich meal. Experiment with different dosages and timing to find what works best for you.

Common Questions about Keto Flow

1. Is Keto Flow safe to use?

Yes, Keto Flow is generally considered safe for most people. However, it’s always a good idea to consult with a healthcare provider before starting any new supplement, especially if you have any underlying health conditions or are taking medications.

2. Can Keto Flow help me lose weight?

While Keto Flow can support weight loss by helping to increase energy levels, suppress appetite, and promote fat burning, it’s important to remember that supplements are not a magic solution. To achieve weight loss goals, it’s essential to combine Keto Flow with a healthy diet and regular exercise.

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3. How quickly will I see results with Keto Flow?

Individual results may vary, but some people report feeling the effects of Keto Flow within a few hours of taking it. However, to experience the full benefits of the supplement, it’s recommended to use it consistently as part of a well-rounded ketogenic diet and lifestyle.