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GLP-1 Agonists for Obesity in Non-Diabetic Patients: Game Changer or Overhyped? | A Critical Clinical Review GLP-1 receptor agonists are reshaping the treatment landscape for obesity—even in patients without diabetes. But are they truly a game-changing intervention or an overhyped pharmacologic trend with major limitations? In this comprehensive analysis, we critically examine the clinical efficacy, cardiovascular outcomes, safety profile, real-world limitations, and economic impact of GLP-1 agonists—drawing from major trials like SELECT, SURMOUNT, and recent meta-analyses. We compare leading agents including semaglutide, tirzepatide, and emerging triple agonists such as retatrutide. You'll learn: How GLP-1 RAs affect appetite, energy homeostasis, and cardiovascular risk Differences in weight loss efficacy among GLP-1 agents in non-diabetic populations Long-term adherence challenges and the risks of weight regain The emerging safety landscape, including GI side effects and perioperative risks Cost-effectiveness concerns, access barriers, and global policy considerations Who is this for? This lecture is designed for physicians, pharmacists, endocrinologists, obesity specialists, and healthcare leaders seeking a balanced, evidence-based perspective on the role of GLP-1s in modern obesity treatment. Whether you're prescribing these agents or designing treatment protocols, this session offers vital insights into optimizing use and anticipating future directions. 🎯 Is it a breakthrough or just hype? We present the evidence—so you can decide. 📌 Subscribe to GlobalRPh for more in-depth clinical content on pharmacotherapy, metabolic health, and practice-changing evidence.

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