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Imagine a treatment that not only helps manage diabetes but also holds the potential to reverse kidney failure — what was once thought to be impossible. The recent FLOW study has remarkable groundbreaking evidence that GLP-1 receptor agonists can significantly improve kidney function in chronic kidney disease (CKD) patients. And while researchers try to understand the full implications of these findings, one thing is clear: the landscape of kidney disease treatment may never be the same again. In this podcast, we’ll dive into the results of the FLOW trial and explore what they may mean for people at risk for kidney failure. What are GLP-1 Agonists? GLP-1 (glucagon-like peptide-1) agonists are a class of drugs that mimic the effects of the natural hormone GLP-1. They enhance insulin secretion, inhibit glucagon release, and slow gastric emptying, improving blood sugar control. Beyond their primary use in diabetes management, GLP-1 agonists have been studied for various conditions, including obesity and cardiovascular disease prevention. The Study Overview The FLOW trial, which stands for "Fasting and Long-acting GLP-1 Receptor Agonist in Patients with Chronic Kidney Disease," focused on the impact of GLP-1 receptor agonists, specifically semaglutide, on patients with chronic kidney disease (CKD) and type 2 diabetes (those most at risk for kidney failure). Researchers observed a remarkable trend: patients receiving semaglutide demonstrated stabilization of kidney function and signs of renal recovery. This was groundbreaking, as reversing kidney damage has long been considered a near-impossible feat. Study Objectives The primary goal was to determine whether treatment with GLP-1 receptor agonists could improve kidney outcomes in patients with CKD. Study Design Participants: The study enrolled >3500 adults with type 2 diabetes and CKD. Intervention: Participants were randomized to receive either semaglutide or a placebo. Primary Outcomes: The main outcomes included changes in glomerular filtration rate (GFR) and the incidence of major adverse kidney events (kidney failure- need for transplantation or dialysis). Key Findings Renal Function Improvement: Patients on semaglutide showed significant improvements in glomerular filtration rates (GFR), a key indicator of kidney function. Reduced Inflammation: The drugs appeared to lower levels of inflammatory markers associated with kidney damage, suggesting a protective effect. Metabolic Benefits: Improvements in blood sugar control and weight loss were also observed, contributing to overall health and potentially alleviating stress on the kidneys. Adverse Events: The treatment was generally well-tolerated, with a favorable safety profile. Ethical Considerations As the results began to emerge, the ethical landscape of the study shifted dramatically. The control group, which was not receiving semaglutide, was found to be at a significantly higher risk of kidney deterioration. With compelling evidence that the GLP-1 agonist was safe and potentially life-saving, the ethics committee determined withholding treatment from any participants was no longer justifiable. Consequently, the study was halted prematurely to allow all participants access to the medication, prioritizing patient welfare over the continuation of research under an inequitable framework. This decision underscores the ethical responsibility of researchers to ensure that all patients receive the best possible care, especially when clear benefits are identified. Implications for Future Research While the early termination of the study raises questions about the completeness of the data collected, it also opens new avenues for further research. The findings encourage more extensive clinical trials to explore the mechanisms behind the renal protective effects of GLP-1 agonists. Additionally, there is a growing interest in investigating these drugs' long-term effects on kidney health and their potential role in preventing disease progression. As further studies unfold, there is hope that GLP-1 agonists will become a standard part of kidney disease management, potentially transforming outcomes for millions affected by this condition. Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

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One Mistake Can Completely Ruin Your Fat Loss Journey I’ve reduced my body fat from 17% to 10% over the past 3 months. Initially, I was eating 2300 calories, and now I’m down to 2000 calories. But most people make a big mistake at the start of their fat loss journey — they cut 300–400 calories from their diet right away. Now understand one thing: the human body needs a certain amount of calories to function properly. That’s why reducing calories has a limit — for example, going down to 1200–1300 calories is only sustainable for a very short period. If from the beginning — when your body fat is still around 20% — you drop 300–400 calories and start eating just 1500 calories in Phase 1 of fat loss, then later on, when your body adapts to that intake, you’ll have no room left to reduce calories further. So what’s the solution? There are two ways to create a calorie deficit: 1. Eat less 2. Increase activity levels So whenever you begin a fat loss phase, start by increasing your activity level, for example by adding 8,000–10,000 steps to your daily routine. This way, you’ll burn an extra 300–400 calories while still eating the same amount of food. Benefits: -You’ll enter a calorie deficit -Your gym strength won’t drop -Muscle mass will be preserved -And later, when needed, you’ll still have the option to gradually reduce calories — helping you avoid the plateau where most people get stuck. #gym #diet #muscles #gymmotivation #fitness #fitnessmotivation #alay #fit #fatlossdiet #weightlossdiet #gymdiet #fulldaydiet #musclebuild #instareel #explorepage #insta #fatloss #meal #highprotein #lunch #bodybuilding #breakfast #preworkout #postworkout #reels #vegetariandiet

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Here is the most important advice I learned about getting an aesthetic physique after 15 years of lifting weights. Coaching: If you want me to coach you on your fitness journey, go to https://go.tomic.com/coaching-brutally-honest-advice to see the results of my coaching program. There you can also apply to work with me. Timestamps: 0:00 - What No One Told Me 0:45 - The Fat Loss Obsession Phase 1:33 - My First Big Disappointment 2:30 - The Reality of Losing Fat 3:31 - Switching To Building The Physique 4:18 - Muscle Building vs. Fat Loss 4:59 - What People Don’t Understand About Building Muscle 5:45 - Deciding To Get Shredded 6:24 - My Experience Getting Under 10% Body Fat 7:23 - Rethinking What’s Realistic as a Natural 8:04 - Physique Standards Subscribe here for more: https://www.youtube.com/subscription_center?add_user=shockingfit Watch this next: What I'd Do If I Had To Lose 40 Pounds of Body Fat https://www.youtube.com/watch?v=Kc1fCcoUnmg About this video: Ever since I started lifting I had a goal of getting an aesthetic physique naturally. I wanted to be one of the guys with visible abs all year round, looking lean and being strong. And it took me years to learn how to get lean and finally get the aesthetic physique I wanted. It definitely wasn’t due to lack of trying. I was consistent with my training and diet. I prioritized sleep. Kept learning and I did the best I knew at the time. The thing is, I didn’t have anyone to tell me what to expect or how to improve my routine. I was mostly figuring things out on my own and if I knew what I know today I would’ve been able to see results in the gym much sooner. So in this video I decided to share my brutally honest advice for building an aesthetic physique as a natural lifter and the most important things I’ve learned over the years. About me: My name is Mario Tomic. I help entrepreneurs and busy professionals get lean, gain muscle, and create systems for a sustainable healthy lifestyle long-term. I started my fitness journey 15 years ago and have been coaching for 10 years. Most people don't know that my native language is Croatian and that I worked in computer science before starting my fitness company. Disclaimer: Mario Tomic is not a doctor or a medical professional. Always consult a physician before starting any exercise program. Use of this information is strictly at your own risk. Mario Tomic will not assume any liability for direct or indirect losses or damages that may result from the use of the information contained in this video, including but not limited to economic loss, injury, or illness.

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