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A 61-year-old man with diabetes, heart failure (EF 25–30%), obesity, and CKD—how do you decide the next step in therapy? In this powerful episode of Case by Case, three expert clinicians dissect a post-hospitalization case involving a patient with multiple overlapping chronic conditions: Type 2 diabetes, HFrEF, obesity, and impaired renal function. The team weighs the benefits and limitations of SGLT2 inhibitors vs. GLP-1 receptor agonists—and the nuances of when to use both. 🎙️ Topics covered include: • Dapagliflozin in heart failure with reduced EF • Semaglutide and emerging data from the FLOW trial • GLP-1 risks in HFrEF: What the evidence (and gaps) suggest • Clinical nuance: when A1C is good but the patient still needs help • How to argue your case with payers using evidence-based trials 🎓 Meet the Experts: • Dr. Marie E. McDonnell (Harvard / Brigham), Endocrinologist and outcomes researcher focused on complex diabetes care. • Dr. Jan N. Basile (MUSC), Clinical hypertension and primary care expert with decades of CME leadership. • Dr. Nihar R. Desai (Yale), Cardiologist and health systems leader pioneering value-driven care. 💬 “It’s not about A1C—it’s about total disease control: renal preservation, CV death, and survival.” 🔗 Register to claim CME for this panel discussion plus more: https://www.cmemeeting.org/online-cme-courses/10th-diabetes-spring-conference 👍 Like, comment, and subscribe for more expert-level clinical cases each episode.
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Peter van der Velden (https://www.linkedin.com/in/petervandervelden/) joins Matt Cohen (https://www.linkedin.com/in/matt-cohen1/) to discuss the dynamic changes within the life sciences sector and venture capital at large. He highlights the success factors in life sciences as a high-performing asset class and discusses the role of Canadian pension funds in supporting innovation. The episode also covers the transformative potential of GLP-1 drugs and AI's impact on drug discovery and medical technology. And John Ruffolo (https://www.linkedin.com/in/joruffolo/) is back to talk about the US elections and tech news. (Note: this was recorded before the election on 11/5/24). About Peter van der Velden: Peter van der Velden is the Founder and Managing General Partner of Lumira Ventures, a top Canadian life sciences venture capital firm he established in 2007 following a management buyout of MDS Capital. At Lumira, he focuses on biotech and medtech investments, with multiple high-profile exits involving acquisitions by major pharmaceutical companies. Prior to Lumira, Peter served as President and CEO of MDS Capital, Canada’s oldest life sciences VC firm. He has also founded and led Fusion Capital, an investment bank for Canadian tech ventures, and worked as Managing Director at Bedford Capital, a private equity boutique. Peter began his career in venture capital in 1988 at Vencap Equities and later held roles in business development at Hyal Pharmaceuticals and Taurus Capital. He holds an MBA from the Schulich School of Business and an MSc in Pathology and a BSc in Life Sciences from Queen’s University. In this episode, we discuss: News with John Ruffolo (1:26) – Super Micro Computer Stock Decline(4:00) – Canadian Perspective on U.S. Elections(6:45) – Decline of Mainstream Media and Rise of Alternative Platforms(11:41) – VCs Backing Multiple Competing LLMs(17:20) – Potential AI Mergers and Acquisitions in 2025 Interview with Peter van der Velden (19:48) – Peter’s Role at Lumira Ventures(21:03) – Transformation in Venture Capital and Life Sciences(24:05) – Life Sciences Outperformance as an Asset Class(27:48) – Canadian Pension Funds and Venture Capital(31:20) – Case Study: Histosonics and Pension Fund Support(35:25) – Quebec’s Leadership in Supporting Local Innovation(37:00) – Challenges in Advocating for Canadian Venture Capital(46:16) – GLP-1 Drugs and Their Transformative Potential(49:19) – Industries Disrupted by GLP-1 Innovations(52:00) – AI’s Role in Drug Discovery and Medtech Fast Favorites * Favorite Podcast: Acquired (https://www.acquired.fm/) and All In (https://podcasts.apple.com/us/podcast/all-in-with-chamath-jason-sacks-friedberg/id1502871393) * Favorite Tech Gadget: NotebookLM.google (https://notebooklm.google/) * Favorite Trend: Rationality returning to the venture market * Favorite Life Lesson: "Never give up" Follow Matt Cohen (https://twitter.com/mattybcohen) and Tank Talks (https://www.rippleventures.com/podcast) here! Podcast production support provided by Agentbee.ai (https://www.agentbee.agency/podcasting) This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit tanktalks.substack.com (https://tanktalks.substack.com?utm_medium=podcast&utm_campaign=CTA_1)
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The makers of the popular weight loss drug Wegovy say new data, from one of their longest medical trials to date, shows the drug has sustained benefits. Novo Nordisk says patients taking the drug maintained an average 10 per cent weight loss after four years on the treatment. After years of persistent shortages, the drug finally became available to Canadians as of last week, despite being greenlit since 2021. Global health reporter Katherine Ward has more on the results of the trial. For more info, please go to https://globalnews.ca/news/10476494/wegovy-drug-canada-weight-loss-drug/ Subscribe to Global News Channel HERE: http://bit.ly/20fcXDc Like Global News on Facebook HERE: http://bit.ly/255GMJQ Follow Global News on X HERE: http://bit.ly/1Toz8mt Follow Global News on Instagram HERE: https://bit.ly/2QZaZIB #GlobalNews #wegovy #wegovyweightloss
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GLP-1 receptor agonists are game-changers for weight management—but how do they actually work? 🤔 These medications regulate appetite, improve metabolic function, and address underlying causes of obesity—making weight loss more sustainable when paired with healthy lifestyle choices. 🥗🏋️♂️ But here’s the kicker—they also support longevity and performance medicine by reducing inflammation, enhancing cognitive function, and promoting overall vitality. 🌿💡 GLP-1s aren’t just a weight loss tool… they’re a metabolic health revolution! 🚀
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