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In this Metabolic Classroom lecture, Dr. Bikman explores GLP-1 receptor agonists (such as Ozempic and Mounjaro) and how to use them more effectively. Ben first explains how GLP-1 is naturally produced in the gut and helps regulate glucagon suppression, slows gastric emptying, and promotes satiety. However, he highlights research showing that individuals with obesity have a blunted GLP-1 response to carbohydrates, which may contribute to overeating. He suggests that GLP-1 drugs could be used more strategically—not just for general weight loss, but specifically to control carbohydrate cravings. While these drugs can promote rapid weight loss, they can also come with serious trade-offs, including mental health risks (depression, anxiety, and suicidal thoughts), lean mass loss (up to 40% of weight lost), diminishing effects over time, and digestive complications such as gastroparesis (stomach paralysis). He critiques the current high-dose, long-term approach to these medications, arguing that most people are not using them strategically and eventually regain lost weight—primarily as fat. Dr. Bikman proposes a better approach to using GLP-1 drugs that focuses on low-dose, short-term usage to help control carbohydrate cravings, rather than suppressing appetite completely. His four-step plan includes: (1) starting at the lowest effective dose, (2) engaging in resistance training to preserve muscle mass, (3) adopting a low-carb, high-protein diet, and (4) cycling off the drug after 3-6 months to assess whether cravings remain under control. He also discusses newer GLP-1/GIP dual agonists like Tirzepatide, which may be even more effective but still require careful usage. In closing, Ben emphasizes that GLP-1 drugs should be a tool, not a crutch. The ultimate goal should be to regain control over eating habits, build long-term dietary discipline, and use the drug only when needed. He encourages those considering these medications to work closely with their healthcare providers and approach them with a long-term metabolic health strategy in mind. Show Notes/References: For complete show notes and references referred to in this episode, we invite you to become a Ben Bikman Insider subscriber. As a subscriber, you’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben, ad-free Metabolic Classroom Podcast episodes, show notes and references, Ben’s Research Reviews Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more: https://www.benbikman.com (Auto-Translate Note: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) #GLP1 #WeightLoss #Ozempic #Mounjaro #Wegovy #GLP1Agonist #MetabolicHealth #FatLoss #InsulinResistance #AppetiteControl #Type2Diabetes #BloodSugarControl #Tirzepatide #ObesityTreatment #HealthyLiving #LowCarbDiet #DrBenBikman #KetogenicDiet #MuscleHealth #MetabolicFlexibility Timestamps (approximate): 00:00 - Introduction: Are We Using GLP-1 Drugs the Right Way? 01:04 - What is GLP-1 & How Does It Work? 02:16 - GLP-1’s Role in Appetite & Blood Sugar Control 05:21 - Obesity & the Blunted GLP-1 Response to Carbohydrates 06:26 - The Problem with Current High-Dose GLP-1 Use 07:40 - Mental Health Risks: Depression, Anxiety, & Suicidal Thoughts 09:54 - Muscle Loss & The Risk of Frailty on GLP-1 Drugs 11:06 - Why GLP-1 Effects Fade Over Time (Diminishing Returns) 12:07 - Digestive Risks: GLP-1 Drugs & Gastroparesis 13:16 - A Smarter Way to Use GLP-1 Drugs: Targeting Carb Cravings 14:21 - Step 1: Use the Lowest Effective Dose 15:29 - Step 2: Preserve Muscle with Resistance Training 16:37 - Step 3: Low-Carb, Protein-Focused Diet 17:47 - Step 4: Cycle Off GLP-1 After 3-6 Months 18:57 - Tirzepatide: GLP-1 & GIP Dual Agonist Overview 20:02 - Final Thoughts: Using GLP-1 Medications Wisely Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite electrolytes (and more): https://redmond.life (discount: BEN15) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15) Ben’s favorite exogenous ketone: https://www.americanketone.com (discount: BEN10) Ben’s favorite dress shirts and pants: https://toughapparel.com/?ref=40 (use BEN10 for 10% off) Other products Ben likes: https://www.amazon.com/shop/benbikmanphd Learn more about becoming an Insider on our website: https://www.benbikman.com
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