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STAT reporter Elaine Chen details how some clinical trial participants report losing too much weight, too quickly on Eli Lilly's next-generation GLP-1 drug, retatrutide. In trials, retatrutide has been shown to cause more weight loss than existing weight-loss products like Ozempic, Wegovy, and Zepbound. More from STAT: Become a subscriber: https://www.statnews.com/stat-plus/ Watch Full Episodes: https://www.youtube.com/@Statnews Newsletters: https://www.statnews.com/signup/ STAT events: https://www.statnews.com/stat-events/ Facebook: https://www.facebook.com/statnews Twitter: https://twitter.com/statnews Instagram: https://www.instagram.com/statnews/ Flipboard: rb.gy/3xnsxr STAT Reports: https://rb.gy/rexfwj STAT eBooks: https://rb.gy/eme3h5 ABOUT STAT: Founded in 2015, STAT is a global digital media brand that focuses on delivering fast, deep, and tough-minded journalism about the life sciences industries to over six million monthly site visitors and an additional 20 million readers on the Apple News app. STAT takes you inside academic labs, biotech boardrooms, and political backrooms, casting a critical eye on scientific discoveries, scrutinizing corporate strategies, and chronicling the roiling battles for talent, money, and market share. With an award-winning newsroom, STAT provides indispensable insights and exclusive stories on the technologies, personalities, power brokers, and political forces driving massive changes in the life sciences industry — and a revolution in human health.
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Semaglutide is a medication that has gained significant attention in recent years for its potential benefits in weight management. Originally developed as a treatment for type 2 diabetes, semaglutide has been found to also aid in weight loss when used in higher doses. This has led to many individuals considering semaglutide as a potential option for achieving their weight loss goals.
The Mechanism behind Semaglutide’s Weight Loss Benefits
Semaglutide works by mimicking the action of a hormone called glucagon-like peptide-1 (GLP-1) in the body. GLP-1 is known to regulate blood sugar levels and appetite, and by increasing the levels of this hormone, semaglutide can help control hunger and reduce caloric intake. Additionally, semaglutide has been found to slow down the emptying of the stomach, leading to a feeling of fullness for longer periods of time.
Furthermore, semaglutide has been shown to increase the body’s sensitivity to insulin, the hormone responsible for regulating blood sugar levels. This can lead to improved blood sugar control and reduced insulin resistance, which are important factors in weight management.
In addition to its effects on appetite and insulin sensitivity, semaglutide has also been found to increase the body’s energy expenditure, or the number of calories burned at rest. This means that individuals taking semaglutide may be able to burn more calories throughout the day, even without increasing their physical activity levels.
Potential Side Effects of Semaglutide
Like any medication, semaglutide may come with some potential side effects that individuals should be aware of before starting treatment. Some of the common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and tend to improve over time as the body adjusts to the medication.
More serious side effects of semaglutide may include pancreatitis, kidney problems, and changes in thyroid hormone levels. It is important for individuals considering semaglutide for weight loss to discuss these risks with their healthcare provider and closely monitor for any concerning symptoms while taking the medication.
It is also worth noting that semaglutide is not suitable for everyone, and individuals with a history of certain medical conditions, such as pancreatitis or thyroid disease, may not be good candidates for this medication. As always, it is important to consult with a healthcare provider before starting any new weight loss treatment.
Combining Semaglutide with Lifestyle Changes
While semaglutide can be a helpful tool in weight management, it is important to remember that it is not a standalone solution. To achieve long-term success with weight loss, individuals taking semaglutide should also focus on making healthy lifestyle changes, such as following a balanced diet and engaging in regular physical activity.
By combining semaglutide with these lifestyle modifications, individuals may be able to achieve even greater weight loss results and improve their overall health. Additionally, maintaining a healthy lifestyle can help individuals sustain their weight loss over time and reduce the risk of regaining lost weight once they stop taking semaglutide.
Overall, semaglutide can be a valuable tool for individuals looking to achieve weight loss goals, but it is most effective when used in conjunction with healthy lifestyle changes. By working with a healthcare provider to develop a comprehensive weight management plan, individuals can maximize the benefits of semaglutide and improve their overall well-being.
Conclusion
In conclusion, semaglutide offers a promising option for individuals struggling with weight management. By targeting multiple aspects of weight loss, including appetite control, insulin sensitivity, and energy expenditure, semaglutide can help individuals achieve their weight loss goals more effectively. However, it is important for individuals to be aware of the potential side effects of semaglutide and to combine its use with healthy lifestyle changes for long-term success. Consulting with a healthcare provider is key to determining if semaglutide is the right choice for weight management and developing a personalized treatment plan.
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