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incretin effect| incretin effect glp-1| incretin effect explained| incretin effect in diabetes| incretin hormones| incretin based therapy of diabetes ▪ Incretins are a group of metabolic hormones that stimulate a decrease in blood glucose levels. Gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are the two primary incretin hormones secreted from the intestine on ingestion of glucose or nutrients to stimulate insulin secretion from pancreatic β cells. The major mechanism of metabolism of the incretins is cleavage by dipeptidyl peptidase 4 (DPP4), an enzyme that is ubiquitously expressed, including in endothelial cells. ▪ Two pharmacological approaches have been taken to enhance the incretin effect in type 2 diabetes. One approach is to administer GLP-1 'analogues' (GLP-1 receptor agonists) that are resistant to cleavage by DPP4. The other approach is to inhibit DPP4 activity. This effectively increases the half-life and therefore the circulating concentrations of the incretins. ▪ In summary, Ingested glucose causes secretion of incretins from GI tract. These ingredients then increase insulin secretion from the pancreas. Anti-diabetic drugs targeting this mechanism are glp1 analogues and dpp4 inhibitors. And in this way, by increasing insulin secretion, the incretins lower blood glucose. Chapters: 0:00 - Insulin Secretion Mechanism 0:42 - Incretin Effect 1:10 - Incretin Hormones 1:26 - Glucagon-like peptide-1 (GLP-1) Hormone 2:19 - Problem in Diabetes 2:35 - GLP-1 analogues and DPP-4 inhibitors 3:24 - Summary of Incretin Effect incretin hormones, incretin effect, incretin effect glp-1, incretin effect explained, incretin effect in diabetes, insulin, diabetes, glucagon like peptide 1, incretin based therapy of diabetes, incretin pathway, incretin and glp-1, glp 1 analogs, dpp4 inhibitors, sitagliptin, vildagliptin, exenatide, liraglutide, oral antidiabetic drugs, mechanism of insulin secretion, insulin secretion, insulin physiology, insulin pharmacology, diabetes mellitus, medicine, pharmacyd by asim ☕ Buy Me A Coffee: https://www.buymeacoffee.com/pharmacyd 💡 Facebook: https://web.facebook.com/pharmacyd0929 For any Queries and Suggestions Email on: [email protected] Disclaimer: "Content is For Informational & Education Purpose Only, Creamed From Various Authentic Books of Pharmacy & Medicine. The Video Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition." A Famous Quote is: "What We Know is a Drop. What We Don't Know is an Ocean".

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💜https://comparesemaglutide.com/semaglutide-comparison-chart---2024 WW has begun to offer Compounded Semaglutide, a GLP-1 as part of their 2025 Weight Loss program. In today’s video, I’m comparing HERS Semaglutide vs. Weight Watchers, which now offers the generic, compounded version of Semaglutide. Semaglutide, initially developed for diabetes, is now widely used for weight loss in both diabetics and those struggling with obesity. HERS ranks #45 and Weight Watchers is #25 out of over 50 online Semaglutide providers, meaning there are at least 24 other providers that offer more affordable options. Be sure to check out my Complete Comparison Chart to see how these providers rank and compare. The process to get started with HERS or Weight Watchers varies. HERS allows you to choose your Semaglutide package, either month-to-month or multiple-month plans. You fill out an intake form and wait for approval, with a money-back guarantee if you don’t qualify. On the other hand, Weight Watchers starts with a quiz to determine if Semaglutide is right for you. To access Semaglutide, you’ll need their all-inclusive membership, which includes access to the WW app, workshops, and dietitian support for $99/month, excluding the medication costs. When comparing costs, HERS offers Semaglutide at $199/month for a 12-month supply, $249/month for 6 months, or $399/month for month-to-month shipments. Weight Watchers charges $129 for the first month, then $189 per month for Semaglutide, plus the $99 monthly membership fee. With the added $49 consult fee, Weight Watchers’ total cost is $288/month, making it more expensive than HERS, which has no additional fees or membership requirements. If you're looking for more affordable options with weight loss support, check out providers like Pomegranate, ranked #4. Don’t forget to check out my full comparison chart to find the best Semaglutide provider for your needs. #semaglutide #semaglutidesuccess #semaglutidejourney #semaglutideforweightloss #semaglutida #semaglutideweightloss #coumpound #weightloss #weightlosstips #weightlossjourney #weightlossmotivation #weightlosstransformation #weightlosschallenge #hers #hims #semaglutidecomparison #semaglutideprescription #semaglutidebeforeandafter #weightlossgoals #weightwatchers #weightlosstips #tipsforweightloss #weightwatchers2025 #ww #noom #wegovy #wegovyforweightloss #wwglp1program * DISCLAIMER*: This post contains affiliate links, through which I may earn a small commission at no cost to you.

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To support this channel and get even more great content, please go to halfsizeme.com/fan. In this powerful episode of the Half Size Me Podcast, Heather is joined by renowned researcher and author Lyle McDonald, who shares science-based insights from his new book, The GLP-1 Solution: A Complete Program to Maximize Weight and Fat Loss Results. Together, they dive deep into the truth behind GLP-1 medications like Ozempic, Wegovy, and Zepbound—what they do, what they don’t, and how to use them effectively while building long-term habits. 🧠 What You'll Learn: ✔️ The misunderstood history of weight loss medications ✔️ Why GLP-1s aren't magic—and what really drives results ✔️ The role of protein intake and strength training during weight loss ✔️ How social media creates false expectations ✔️ Why lifestyle change is still the key—even on medication ✔️ The dangers of compounding pharmacies and underdosing ✔️ How to build a real plan before starting GLP-1s 🎯 Whether you're already on a GLP-1 medication or thinking about it, this conversation gives you the real, practical, and science-backed roadmap for lasting results. Disclaimer: Heather is not a doctor, nurse, or certified health professional and what works for her or her guests may, or may not, work for you. So, please be sure to talk with your doctor, dietician, or other certified health professional when seeking advice about your own weight loss or weight maintenance plan. All information included in The Half Size Me™ Podcast, YouTube channel, social media, and on HalfSizeMe.com is for informational and inspirational purposes only.

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00:00 - Intro 00:29 - Major Insurance Changes for GLP-1 Drugs: Impact on Weight Loss Patients 07:03 - Wegovy & Zepbound Price Drop: Will Access Improve? | Obesity Drug Costs Explained 13:30 - How to Get GLP-1 Weight Loss Drugs Covered by Employer Health Insurance 17:55 - CVS Drops Zepbound: Weight Loss Drug Coverage Cut Explained | GLP-1 Costs & Impact 1. Major Insurance Changes for GLP-1 Drugs: Impact on Weight Loss Patients CVS Caremark and BCBS Massachusetts are altering coverage for GLP-1 weight loss drugs like Zepbound and Wegovy, causing stress for patients. Learn how these insurance changes affect access to medications, the rationale behind formulary shifts, and the broader debate on obesity as a chronic disease. Experts and patients share concerns about disrupted treatment plans, rising costs, and the role of pharmacy benefit managers in drug pricing. Discover alternatives like LillyDirect and the challenges of navigating insurance-mandated switches. #GLP1Drugs #WeightLossTreatment #nhânquả 2. Wegovy & Zepbound Price Drop: Will Access Improve? | Obesity Drug Costs Explained Explore the latest developments in obesity medication costs as Wegovy and Zepbound prices decline. Learn why access remains a challenge for many patients, even with insurance coverage. This video breaks down the current costs ($500/month without insurance), coverage issues with Medicare and Medicaid, and the role of PBMs in formulary decisions. Discover alternatives like compounded semaglutide from companies like Hims & Hers Health, and how upcoming pill versions might further reduce prices. We also discuss employer coverage trends, patient assistance programs, and international pharmacy options. Stay informed on the ongoing debate around GLP-1 agonist affordability and what it means for your healthcare. 3. How to Get GLP-1 Weight Loss Drugs Covered by Employer Health Insurance Discover practical strategies to help employees access GLP-1 medications for obesity and cardiometabolic diseases through employer-sponsored health insurance. This video explains the current challenges in drug pricing, insurance coverage gaps, and a proposed plan to make these life-changing drugs more affordable and accessible. Learn about the role of rebates, employer cost-sharing, and the impact of policy decisions on coverage. Plus, find out why GLP-1 drugs are clinically important yet often unavailable under employer plans, and how simplifying the payment system could improve public health. Keywords: GLP-1 coverage, employer health insurance, obesity treatment drugs, drug pricing in the US, Wegovy, Ozempic, weight loss medication insurance, cardiometabolic disease, pharmaceutical rebates, healthcare affordability. 4. CVS Drops Zepbound: Weight Loss Drug Coverage Cut Explained | GLP-1 Costs & Impact CVS Caremark, one of the largest pharmacy benefit managers in the U.S., has stopped coverage for Eli Lilly’s weight loss drug Zepbound, citing unsustainable costs. Learn why GLP-1 medications like Zepbound and Wegovy are driving up plan expenses and how this decision impacts patients relying on these obesity treatments. We break down the reasons behind CVS’s move, including the "egregiously high list prices" set by drug manufacturers, and explore the exceptions for medical necessity. Hear from experts like Dr. Christopher McGowan, who warns that switching medications mid-treatment can reverse progress and harm long-term health outcomes. Plus, discover Eli Lilly’s response, including discounted self-pay options through LillyDirect. Stay informed about the ongoing battle between PBMs, drugmakers, and patients in the weight loss medication space. Keywords: CVS Caremark, Zepbound coverage, weight loss drugs 2024, GLP-1 medications cost, Eli Lilly, obesity treatment, pharmacy benefit managers, Wegovy vs Zepbound, tirzepatide, medical necessity exceptions.

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