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GLP-1 Myths Busted: Desensitization, Damage, and Downregulation Explained If you need assistance in your journey to reach your weight loss goals, book a consultation with me: https://calendly.com/drdanburton/weight-loss-consult ✨ Join Dr. Dan’s Empowerment Hub 👉 https://drdans-empowermenthub.mn.co/ Discover sustainable, evidence-based solutions to transform your health and embrace self-care without guilt. Connect with a supportive community, get daily affirmations, and create lasting vitality. Don’t wait—click to learn more and start your journey today! Join this channel to get access to perks: https://www.youtube.com/channel/UCnQiofnuXFcloJRoJTsc1FQ/join Download my FREE GLP-1/GIP Medication Information Sheet and 7-Day Food Journal: http://eepurl.com/gdB2qn Try my fancy dancy Total Daily Energy Expenditure (TDEE) Calculator: https://healthevolved.co/tdee-calculator/ Subscribe to the channel: https://www.youtube.com/@theofficialdrdan?sub_confirmation=1 – Have you ever heard someone say that GLP-1 medications like Wegovy, Ozempic, or Zepbound stop working over time—or worse, that they damage your GLP-1 receptors? Some even suggest cycling off these medications to “reset” your system. Let me set the record straight. In this video, I’m busting myths about desensitization, damage, and downregulation of GLP-1 receptors. I’ll walk you through the science of how these medications actually work, why they don’t “wear out” your receptors, and what real-world studies like SELECT and STEP 5 tell us. (Spoiler: these meds keep doing their job even when weight loss slows down.) We’ll talk about the realities of weight-loss plateaus, how your body’s natural metabolic adaptations come into play, and why cycling off these meds might make it harder to reach or maintain your goals. I’ll also share why managing expectations is so important and how to navigate the noise from influencers and misinformation online. Thanks for watching! 00:00 Introduction 00:40 GLP-1 Receptor Agonist Recap 01:34 Studies on desensitization or down-regulation 02:13 Dr. Dan’s Empowerment Hub 03:03 SELECT & STEP 5 Trials 04:45 Plateaus post-weight loss & grand expectations 06:24 So what’s going on? 08:11 Yesoul Fitness Bike - promo: DRDAN 09:11 Cycling medication & the Surmount 4 Trial 10:25 Yo-yo dieting 11:05 Final thoughts – Watch my previous videos about how to fight obesity and about the best medicine for weight loss: ▪️ Food Noise: https://youtu.be/8qC2S638WBg ▪️ Watch This Before Taking Mounjaro: https://youtu.be/BmkVtGgejhk ▪️ From Ozempic to Mounjaro: https://youtu.be/L9e46iFWwIs ▪️ Muscle Loss with Ozempic, Wegovy & Mounjaro: https://youtu.be/lnEH-v64aG0 ▪️ Managing Nausea from Ozempic, Wegovy and Trulicity!: https://youtu.be/3R1Fwhf02LE ▪️ Ozempic: Stomach Paralysis Update: https://youtu.be/MPyROywaM0g ▪️ How to Switch from Ozempic (or Wegovy) to Mounjaro: https://youtu.be/L9e46iFWwIs ▪️ Ozempic Paralyzed My Stomach: https://youtu.be/tj9thkkN5aM ▪️ How to Inject Mounjaro: step-by-step tutorial: https://youtu.be/piVHr7UqYDg Products I recommend to support your weight-loss journey: ▪️ Managing Constipation: https://amzn.to/4bs0g3h ▪️ Managing Diarrhea: https://amzn.to/3UUjNCm ▪️ Managing Heartburn: https://amzn.to/3Vbfx31 ▪️ Internalized Weight Bias: https://amzn.to/4avCpP3 ▪️ Protein Bars: https://amzn.to/3RiItUr ▪️ Scales and More: https://amzn.to/4bNJDPc ▪️ Supplements: https://amzn.to/44TgobJ ▪️ Activity Trackers I recommend: https://amzn.to/4dOYLOa ▪️ My favorite Books: https://amzn.to/3Kb0VKt 🇺🇸 USA: https://amzn.to/3RC7MSd 🇨🇦 Canada: https://amzn.to/45gq4vg – Live in Alberta? Come see me at my Pharmacist-led Obesity Clinic at Apothecare Pharmacy - http://apothecarerx.ca – Sign up for my newsletter: http://eepurl.com/gdB2qn – Contact Me: [email protected] – For more about weight loss via habit mastery, visit https://www.healthevolved.co Join me on social media: ▪️ https://www.facebook.com/theofficialdrdan ▪️ https://www.instagram.com/theofficialdrdan Disclaimer of Medical Liability. HEALTHCARE EVOLUTION INC. DOES NOT PROVIDE MEDICAL ADVICE. The content of this material is for general informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Reliance on any information provided here is solely at your own risk. Individual medical needs are very different; you should not assume that the information in this document concerning certain courses of treatment or outcomes will apply to you. Rather, you should evaluate your medical condition and make treatment decisions based upon consultation with your physician. #WeightLossMedications #Obesity #WeightLoss
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Semaglutide is a medication that has gained attention in recent years for its potential in promoting weight loss. Originally developed for the treatment of type 2 diabetes, researchers have found that at higher doses, semaglutide can also lead to significant reductions in body weight.
Understanding Semaglutide for Weight Loss
Semaglutide is a glucagon-like peptide-1 receptor agonist that works by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1) in the body. GLP-1 is released after eating and helps regulate blood sugar levels by stimulating insulin secretion and reducing glucagon production. It also slows down gastric emptying, leading to feelings of fullness and reduced food intake.
At lower doses, semaglutide is used for the management of type 2 diabetes. However, studies have shown that at higher doses, semaglutide can promote weight loss in people who are overweight or obese, even without diabetes. This has made it a promising option for individuals looking to achieve and maintain a healthier weight.
One of the advantages of semaglutide for weight loss is its ease of use. It is typically administered once a week via a subcutaneous injection, making it a convenient option for many patients. In addition to its potential for weight loss, semaglutide has also been shown to have other benefits, such as improvements in cardiovascular risk factors like blood pressure and cholesterol levels.
Recommended Dosage of Semaglutide for Weight Loss
The recommended dose of semaglutide for weight loss is 2.4 mg once a week. This higher dose has been found to be more effective in promoting weight loss compared to lower doses. In clinical trials, patients taking semaglutide at this dose experienced significant reductions in body weight, with many achieving weight loss of 10% or more.
It is important for individuals considering semaglutide for weight loss to consult with a healthcare provider before starting treatment. A healthcare provider can evaluate the patient’s medical history, current medications, and weight loss goals to determine if semaglutide is a suitable option. They can also provide guidance on how to properly use and dose the medication for optimal results.
In addition to the recommended dose of 2.4 mg once a week, it is essential for individuals taking semaglutide for weight loss to maintain a healthy diet and exercise regularly. While semaglutide can help support weight loss efforts, lifestyle modifications are also necessary for long-term success. By combining semaglutide with healthy habits, individuals can maximize their weight loss results and improve their overall health.
Potential Side Effects of Semaglutide for Weight Loss
Like any medication, semaglutide can cause side effects in some individuals. Common side effects of semaglutide for weight loss may include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild to moderate in severity and tend to improve over time as the body adjusts to the medication.

In rare cases, more serious side effects may occur with semaglutide use. These can include pancreatitis, gallbladder problems, and thyroid tumors. It is essential for individuals taking semaglutide to be aware of these potential risks and to seek medical attention if they experience symptoms such as severe abdominal pain, jaundice, or changes in thyroid function.
Overall, the benefits of semaglutide for weight loss typically outweigh the potential risks for many individuals. By working closely with a healthcare provider and following their guidance, patients can safely and effectively use semaglutide to support their weight loss goals and improve their overall health.
Future Research and Developments in Semaglutide for Weight Loss
As the understanding of semaglutide and its effects on weight loss continues to evolve, researchers are exploring new ways to optimize its use and effectiveness. Future studies may focus on identifying the ideal dosing regimens, combination therapies, and patient populations that can benefit most from semaglutide treatment.
In addition to its role in weight loss, semaglutide may also show promise in other areas of health and wellness. Research is ongoing to investigate its potential effects on conditions such as non-alcoholic fatty liver disease, cardiovascular disease, and even cancer. By expanding our knowledge of semaglutide, we can unlock new opportunities for improving health outcomes and quality of life for patients.
Overall, semaglutide represents a valuable tool in the fight against obesity and its associated health risks. With its proven efficacy in promoting weight loss and improving metabolic health, semaglutide offers hope for individuals struggling to achieve and maintain a healthier weight. By staying informed about the latest research and developments in semaglutide, healthcare providers and patients can work together to harness the full potential of this groundbreaking medication.
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The top 6 vitamins that boost the metabolism for fat loss. Your metabolism is a set of different processes in your body that convert food and drinks into energy. When you're trying to lose weight and keep it off, it's important to have a healthy metabolism to help your body burn excess fat. Unfortunately many people have a slow metabolism due to yoyo dieting, eating too many junk foods, hormonal imbalances and problems with digestion. This makes it harder to burn body fat (lipolysis), making you feel more tired, lethargic, and craving when you're losing weight. In this video we take a look at the root causes of a slow metabolism, and the top 6 vitamins to boost your metabolism including B-complex, apple cider vinegar, potassium & magnesium, turmeric, vitamin D and trace minerals. These supplements/remedies help to improve fat metabolism by helping to boost the BMR (basal metabolic rate), and balancing hormones (insulin & cortisol). Some great metabolism boosting supplements: 🌿Nutritional Yeast (B-Vitamins): https://amzn.to/3E4qQjD 🌿Vitamin D: https://amzn.to/3UWI3Cs 🌿Potassium Citrate: https://amzn.to/3X4o5aP 🌿Apple Cider Vinegar: https://amzn.to/3Nz7Gqi 🌿Digestive Enzyme Blend: https://amzn.to/3UlvQaF 🌿Turmeric: https://amzn.to/3X1XGu3 ----- Timestamps: ⏰ 00:00 - Intro, What Is Metabolism? ⏰ 00:22 - Benefits Of High Metabolism ⏰ 02:09 - 1. Vitamin B-Complex ⏰ 03:29 - 2. Apple Cider Vinegar ⏰ 04:40 - 3. Potassium & Magnesium ⏰ 06:33 - 4. Turmeric ⏰ 07:37 - 5. Vitamin D ⏰ 08:59 - 6. Trace Minerals ⏰ 10:57 - Causes Of Slow Metabolism ⏰ 12:18 - How To Boost Your Metabolism ----- Our Nature Inspired Clothes & Posters https://my-store-5990720.creator-spring.com/ ------ 🌏 Follow Us: Facebook: https://www.facebook.com/ryansnaturalremedies/ TikTok: https://www.tiktok.com/@rtnaturalremedies ----- Tags: #metabolism #weightloss #fatburning ----- Graphics Credits: Vecteezy.com, Freepik.com 🐝 Making life enhancing videos is extremely important to me. I love sharing useful knowledge with you. Please let me know if there are any natural remedies or topics you wish for me to research. See my other videos on healthy foods for more info. 💚 I wish you great health, wealth and happiness. Disclaimer: The materials and information contained on Ryan Taylor’s channel are provided for educational and general purposes only and therefore are no substitute for informed medical advice or care. Please consult a medical doctor to seek treatment for any illnesses or medical concerns you may have. Affiliate Disclaimer: This video and description may contain affiliate links, which means that if you click on one of the product links, I'll receive a small commission. This helps to support the channel so that I may invest more time in making informative videos.
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💊 Are GLP-1 Drugs Beneficial or Challenging? Let’s Uncover the Truth! 💊 GLP-1 medications like Ozempic, Wegovy, Zepbound, and Mounjaro have gained massive attention for weight loss and diabetes management—but are they truly beneficial, or do they come with hidden challenges? 🤔 In this episode of Healthy by George, we break down: ✅ How GLP-1 drugs work in the body 🧬 ✅ The benefits for weight loss and blood sugar control 🏥 ✅ Potential side effects and long-term concerns ⚠️ ✅ Who should (and shouldn’t) consider using them ❓ While these medications have transformed many lives, there’s more to the story than just weight loss. Understanding the pros and cons is key to making informed health decisions! 💡 💬 Have you or someone you know used GLP-1 drugs? Share your experiences in the comments! Don’t forget to like, subscribe, and share to help others stay informed. A journal article was recently published looking at all the available weight loss drugs—mounjaro, wegovy, zepbound, and Ozempic—and new triple G inhibitors being researched. What are we learning? MC shares that these drugs not only help with weight loss, but we are learning they are helpful in other chronic conditions: Substance use disorders Suicidal ideation and schizophrenia Alzheimer's disease and dementia Clotting disorders and infections Chronic obstructive pulmonary disease and liver diseases Chronic obstructive sleep apnea Clearly, these medications are working on a brain-gut association that appears to help in ways that can help reduce individuals from progressing and deteriorating? The question is, why are the drug companies making access to these drugs a challenge by charging such high prices? Plus, physicians and patients are becoming creative with "off-label" use by microdosing. MC shares that she didn't follow the typical aggressive dosing that the research studies did; she stayed on a low dose until she was no longer losing weight on the current dose. MC was on the lowest dose of mounjaro for almost 6 months, losing a small amount each month until it plateaued. This has been MCs approach for each dose of the drug. To stay on that dose until she is no longer getting any benefit. MC believes this has helped her stay on the drug despite some side effects and work with her doctor on the side effects so that they became less and less as time progressed. Now, individuals and physicians use microdosing with GLP1 drugs available from compound pharmacies. Some individuals report many benefits unrelated to obesity but to menopause and its symptoms, but let's do this with the help of our medical professionals. Danger can be possible due to the inability to maintain sterilization when we are reusing drugs in a vial multiple times. Each time we stick the needle into the vial, there is a potential for contamination. Plus, we don't know the long-term problems that could be present from taking microdoses because research has not been done. No matter what your choice is, now is the time to investigate the various ways to help yourself with obesity and other chronic conditions and those reputable online companies or your local doctor to make choices for your health when it comes to using these drugs. MC checks in monthly with her coach and then every quarter with a nutritionist. She also plans to perform a scan to determine her fat-to-muscle ratio and a test to help her understand her metabolism. Be well, my friends. We have this one precious life; let's live it intentionally. 🌿💚 📌 Disclaimer: The views shared here are solely for education and entertainment. They are not endorsed by my employer or any affiliated companies. This content reflects personal perspectives, and I encourage everyone to consult with healthcare professionals for medical advice. Follow us on Social Media: Youtube : https://www.youtube.com/@healthybygeorge3425/videos 🔥INSTAGRAM: https://www.instagram.com/healthybygeorge6/ 💎WEBSITE: https://www.marycatherinegeorge.com/ 🔮FACEBOOK: https://www.facebook.com/profile.php?id=100071895693054 📧 For Business Inquiries 📧 Mail: [email protected] ⚠️ hashtags⚠️ #glp1 #ozempic #wegovy #mounjaro #weightlossdrugs #diabetesmanagement #bloodsugarcontrol #healthybygeorge #weightlossjourney #healthyliving #metabolichealth #obesitytreatment #medicalbreakthrough #glp1sideeffects #insulinresistance #wellnessjourney #guthealth #fitnessandhealth #hormonalbalance #weightlosstransformation #diabetesawareness #hearthealth #lifestylemedicine #nutritionmatters #sciencebasedhealth #stayhealthy #informeddecisions #medicationsafety #holistichealth #preventdisease #healthiswealth
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