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Download my book Master Your T for free here - https://u.mzu.to/myt1 Will your body naturally produce enough testosterone to keep your levels where they are if you were to stop using TRT? No, it won’t. At the very least it will take a significant amount of time to restore your natural endocrine function. What is Testosterone? Testosterone is the principal male hormone. An androgen. It is found in both males and females, and acts anabolically. While females naturally produce small amounts of testosterone, and have far greater sensitivity to the introduction of additional testosterone into their systems, males, clearly, are where testosterone is most prevalent (7- 10+ times the natural amount of females), and in whom higher testosterone is most often desired. It is secreted in the tests of males, and ovaries of females, with small amounts also coming from the adrenal glands. Testosterone gets to work, in both males and females, before we’re even born and carries out its influence heavily first during the s-xual diﬀerentiation process, then into infancy, prepubescence, puberty, adolescence, and adulthood. T plays a role in many processes in the body, one of the more prominently known being spermatogenesis. Without the presence of testosterone and/or the androgen receptor, spermatogenesis can’t proceed past meiosis. In non-sciency terms, you’re infertile. So now that we know where testosterone is produced, let’s venture a guess at what may be the cause of low testosterone production. There are two common culprits, and they’re medically recognized as primary and secondary hypogonadism. The first, primary hypogonadism, is caused by deficient testosterone production in the tests. The second, secondary hypogonadism, is caused by hypothalamic- pituitary irregularities. They regulate your endocrine system. So for example, secondary hypogonadism can be caused when a piece of this puzzle isn’t functioning properly. I’m of the opinion that these processes (primary + secondary hypogonadism) do not operate independently, as evidenced by the strong influence of the hypothalamus and pituitary gland on the gon-ds directly. So in the end, it all comes back to brain health. And therefore... gut health. Your gut is your second brain. And you can directly influence its health with what you put into your body for nutrition. NOW we’re getting somewhere. You’ll recall that testosterone is produced in the tests by cells called Leydig cells. The average plasma concentration of testosterone in human males typically falls between the range of 200 – 1000 ng/dl. In terms of timeline vs plasma concentrations over a lifetime, T levels rise sharply during adolescence, peak in a man’s 20′s, then begin a slow decline with age. While its most potent and widely recognized eﬀect on the human male body is its influence over the growth/development of s-xual tissues, your testosterone level is also a good indicator of lean body mass (ie. muscle) potential, with the right stimuli. Elevated testosterone levels will increase red blood cell production, bone density, sugar uptake into muscle tissue, muscle glycogen storage, and protein synthesis associated with muscular growth. The Feedback Loop The cascade of events leading to testosterone production begins in the hypothalamus with the release of GnRH (gonadotropin releasing hormone) which acts on the pituitary to produce two hormones: LH (luteinizing hormone) and FSH (follicle stimulating hormone). These are the gonadotropins. Once in the bloodstream, LH makes its way to the testicles where it exerts its influence on the Leydig cells, triggering a series of events that turns cholesterol into testosterone. As testosterone levels increase, LH production & transport slows. A negative feedback loop. The body and brain are communicating constantly in order to regulate important processes. This is one of countless feedback loops (there are many positive feedback loops as well) in the human body. With this negative feedback loop, the brain can constantly keep hormone levels in check – in this case, testosterone, LH, FSH, and GnRH – under normal, healthy circumstances. When a problem arises anywhere on this pipeline, be it from a tumor, traumatic stressor, or summative build-up of small, unnoticeable toxic stress (super common) – not only is everything downstream aﬀected, everything period is aﬀected. Because it’s a loop. You’ll notice that testosterone doesn’t only linearly exert its influence back on the hypothalamus alone, it can also work directly back on the pituitary (essentially “skipping” a step) if your body is looking to quickly regulate gonadotropin release At this point we understand that testosterone production is regulated by the brain, namely the hypothalamus and pituitary, via a handful of powerful hormones. And it’s synthesized after a number of intermediate steps, from cholesterol in the Leydig cells. And this process is all tied together in a negative feedback loop.

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