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https://www.wisepowder.com/product-details/74-79-3/ L(+)-Arginine powder is an amino acid that helps make proteins. It also becomes the gas nitric oxide (NO) in the body. NO is important for erectile function because it helps blood vessels relax, so more oxygen-rich blood can circulate through your arteries. Healthy blood flow to the arteries of the penis is essential for normal erectile function. L(+)-Arginine (74-79-3) Mechanism Of Action Arginine plays an important role in cell division, wound healing, removing ammonia from the body, immune function, and the release of hormones. It is a precursor for the synthesis of nitric oxide (NO), making it important in the regulation of blood pressure. Proteins Arginine’s side chain is amphipathic, because at physiological pH it contains a positively charged guanidinium group, which is highly polar, at the end of a hydrophobic aliphatic hydrocarbon chain. Because globular proteins have hydrophobic interiors and hydrophilic surfaces, arginine is typically found on the outside of the protein, where the hydrophilic head group can interact with the polar environment, for example taking part in hydrogen bonding and salt bridges. For this reason, it is frequently found at the interface between two proteins. The aliphatic part of the side chain sometimes remains below the surface of the protein. Arginine residues in proteins can be deiminated by PAD enzymes to form citrulline, in a post-translational modification process called citrullination.This is important in fetal development, is part of the normal immune process, as well as the control of gene expression, but is also significant in autoimmune diseases. Another post-translational modification of arginine involves methylation by protein methyltransferases. Precursor Arginine is the immediate precursor of NO, an important signaling molecule which can act as a second messenger, as well as an intercellular messenger which regulates vasodilation, and also has functions in the immune system’s reaction to infection. Arginine is also a precursor for urea, ornithine, and agmatine; is necessary for the synthesis of creatine; and can also be used for the synthesis of polyamines (mainly through ornithine and to a lesser degree through agmatine, citrulline, and glutamate.) The presence of asymmetric dimethylarginine (ADMA), a close relative, inhibits the nitric oxide reaction; therefore, ADMA is considered a marker for vascular disease, just as L(+)-Arginine is considered a sign of a healthy endothelium. 07 L(+)-Arginine (74-79-3) Application L(+)-Arginine has been studied extensively as a possible treatment for ED and many other conditions. The results suggest that the supplement, though generally safe and well-tolerated by most men, won’t help restore healthy erectile function. The Mayo Clinic gives L(+)-Arginine a C grade when it comes to scientific evidence of successful ED treatment. However, L(+)-Arginine is often combined with other supplements, which have different results. Here’s what the research has to say: L(+)-Arginine and yohimbine hydrochloride Yohimbine hydrochloride, also known as yohimbine, is an approved treatment for ED. A 2010 studyTrusted Source of the combination of L(+)-Arginine and yohimbine hydrochloride found the treatment shows some promise. However, the study showed that the treatment is meant only for mild to moderate ED. L(+)-Arginine and pycnogenol While L(+)-Arginine alone may not treat your ED, the combination of L(+)-Arginine and an herbal supplement called pycnogenol may help. A study in the Journal of Sex and Marital Therapy found that L(+)-Arginine and pycnogenol supplements helped a significant number of men ages 25 to 45 with ED achieve normal erections. The treatment also didn’t cause side effects that occur with ED medication. Pycnogenol is a trademark name for a supplement taken from the pine bark of a tree called the Pinus pinaster. Other ingredients may include extracts from peanut skin, grape seed, and witch hazel bark.

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