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CBD Based Hemp CannabisStory of Charlotte’s Web Who was Charlotte Figi? Charlotte Figi, a child with a catastrophic type of epilepsy. She became a symbol of the positive impacts that CBD can have. Charlotte had Dravet syndrome, a rare form of epilepsy Sadly she passed away April 7th, 2020 at the age of 13 Cause of death thought to be pneumonia Rare Form of Epilepsy (Dravet syndrome) Dravet syndrome, a rare form of epilepsy where the seizures start during the first year of life. Charlotte at the age of 6 was having a seizure every 30min. Over Two Years Her Parents (Paige and Matt) Tried… Diet alterations Acupuncture Drugs (Ex. Valent, Adavan, Penabarbrotol) Some medications nearly lead to her death (beathing and heart stopping) With no changes from any of the above. At peak Charlotte was having 300 seizures a week (~2 per hour) and was not talking or moving Doctors had provided two options… Veterinary drug used on epileptic dogs Medically induced coma Half a World Away… Father Matt was deployed to Afghanistan and was researching online. He found evidence that cannabis can help reduce seizures The Stanley Brothers The Stanley brothers, marijuana growers in Colorado, were crossbreeding a strain of marijuana high in CBD and low in THC, its psychoactive ingredient. Their focus was the breed down the THC and up the CBD They were able to achieve a CBD level of 21% while still maintaining a THC level under 1%. Reason was not for recreational smoking, but for its potential medical benefits Flower to Extraction Mother went to a local Denver, CO dispensary and purchased some high CBD variety cannabis. Owner was surprised of the request since nobody wanted it because it did not have any effect. Low THC and High CBD Thought to potentially be “R4”: THC: 0.76% and CBD: 17.61% After taking the flower home she extracted the CBD Impact of CBD Treatment The day she was given a CBD oil treatment under the tongue she did not have a seizer that day which continued into the night and beyond. Overall there was a sharp decline in seizures. She went from 300 seizures a week to only have 1 a week! She went from a feeding tube to eating on her own She started talking and also walking Does: Charlotte’s Web = CW2A (?) According to the U.S. Patent and Trademark Office, Joel Stanley filed the patent application in May 2018 on behalf of his company, also named Charlotte’s Web. In the public documents, Stanley described a plant type capable of producing 6.24-percent CBD content and 0.27-percent THC content. The patent was approved in July 2019 “The new cultivar of ‘CW2A’ was asexually reproduced via stem cuttings from vegetative and/or flowering plants, and cloning by the inventor at the inventor’s greenhouses, nurseries, fields and/or facilities in Colorado Springs, Colo., and Wray, Colo.,” according to the patent. “Asexual clones from the original source have been tested in greenhouses, nurseries, and/or fields. The properties of each clone from this cultivar were found to be transmissible by such asexual reproduction. The cultivar is stable and reproduces true to type in successive generations of asexual reproduction.” Plant Patent Specifics The patent issued to CWB Holdings is a plant patent, not a broader utility patent This means it is good only for legal protection against a competitor growing the same cultivar from clone. Even though this may be overall limited protection it is groundbreaking in that this is the first and only plant patent for a hemp cultivar issued in the United States. Value of a Patent The patent does not prevent others from developing their own strain of similar characteristics. The goal from the breeders stand point is to protect the strain you have put time and resources into developing. The patent does not prevent competition, but can provide an advantage in the market. Charlotte’s Web Specifics Sativa based strain with a stated 13% CBD However, patent states 6.24% CBD and 0.29% THC These unique and proprietary genetics are used by Charlotte's Web (the company) to create extracts for a variety of health and wellness products. Contrary to popular belief, Charlotte’s Web products are hemp-derived and are non-intoxicating. New consumers should consult their doctor with any medical concerns. Link to Lecture Slides: https://drive.google.com/file/d/1p_Fndnj4Ypl050Fs0idAHQczIB9hh2a-/view?usp=sharing *Due to the description character limit the full work cited for "CBD Based Hemp Cannabis Story of Charlottes Web" can be viewed at... https://drive.google.com/file/d/1kbRR2BLwpxrckZg96HiEPaHwa_mSXJ7r/view?usp=sharing

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