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This is a brief comparison of semaglutide, tirzepatide and retatrutide. All of these weight loss medications have solid research surrounding them. Semaglutide is probably the most popular as it currently stands. You've probably seen Oprah's weight loss story with this medication. Semaglutide works on the GLP-1 receptor. GLP-1 Receptor Agonists work by slowing down digestion and working on the central nervous system to quiet down food noise. TIrzepatide is a GLP-1 and GIP receptor. This also aids in weight loss by slowing down digestion and potentially allowing the body to use fat more effectively for energy. There may even be some evidence indicating that GIP receptor activation can change white fat into brown fat, which can slightly improve calorie expenditure. Retatrutide activates GLP-1, GIP, and GCG (glucagon). There may be some independent effects of muscle preservation with glucagon receptor activation. At the end of the video I compare semaglutide, tirzepatide, and retatrutide side by side. I understand this is slightly oversimplified but I think it does a good job expressing the general differences between them. The only thing I would have changed would have been the lean tissue loss while on these medications. 00:00 - Intro 00:21 - Semaglutide 03:21 - Tirzepatide 06:35 - Retatrutide 08:30 - Side by Side Steelhealthandhormonescentre.com

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