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Dr. James Hill—a expert on obesity, metabolism, and long-term weight management—joins me this week to unpack the biggest challenges in sustainable fat loss. Dr. Hill has spent decades researching weight control and the factors that determine whether people can keep weight off long-term. We discuss the science behind energy balance, metabolic flexibility, and why long-term weight loss is about more than just diet and exercise. He shares insights from his groundbreaking work with the National Weight Control Registry, the role of GLP-1 medications, and why physical activity is the key to preventing weight regain. We cover: The critical differences between weight loss and weight maintenance Why physical activity is perhaps more important for keeping weight off than losing it The National Weight Control Registry: lessons from long-term weight loss success stories How metabolism, muscle mass, and energy expenditure affect weight regain The role of protein and resistance training in preserving lean mass The impact of GLP-1 medications on weight loss and why most people regain weight after stopping them The psychology of weight maintenance: mindset, self-monitoring, and behavior change If you’ve ever struggled to keep weight off, or you’re interested in the latest research on metabolic health and sustainable weight management, this episode is a must-listen. Who is Dr. James Hill? Dr. James Hill is an internationally recognized expert on obesity, metabolism, and weight management. He is the co-founder of the National Weight Control Registry, the largest ongoing study tracking individuals who have successfully lost weight and kept it off long-term. Dr. Hill has published over 400 scientific articles and has led pioneering research on energy balance, metabolic flexibility, and the role of physical activity in weight maintenance. He is a professor at the University of Alabama at Birmingham and has served as the President of The Obesity Society. His work has been instrumental in shaping modern obesity treatment and prevention strategies. This episode is brought to you by: Puori - Code DRLYON for 20% off sitewide!– https://Puori.com/DRLYON Cozy Earth - Code DRLYON for up to 40% off! – https://cozyearth.com/DRLYON BON CHARGE - Code DRLYON for 15% off! - https://boncharge.com/DRLYON Manukora- Get $25 off the Starter Kit at https://manukora.com/DRLYON Find Dr. James Hill at: International Weight Control Registry https://internationalweightcontrolregistry.org/ Scholars Profile - https://scholars.uab.edu/6698-james-hill Academic Website - https://www.uab.edu/norc/about-us/leadership/executive-committee/james-hill Find me at: Instagram: @drgabriellelyon TikTok: @drgabriellelyon Facebook: facebook.com/doctorgabriellelyon YouTube: youtube.com/@DrGabrielleLyon X: x.com/drgabriellelyon Apply to become a patient - https://drgabriellelyon.com/new-patient-inquiry/ Join my weekly newsletter - https://institute-for-muscle-centric-medicine.ck.page Get my book - https://drgabriellelyon.com/forever-strong/ Forever Strong Summit 2025 - Grab your ticket NOW before we sell out! https://drgabriellelyon.com/forever-strong-summit-2025/ Timestamps: 00:00 - Intro & Forever Strong Summit Announcement 02:21 - Meet Dr. James Hill 04:34 - Why obesity wasn’t always a major concern 08:12 - The truth about energy balance and weight loss 14:42 - Weight loss vs. weight maintenance: why they require different strategies 18:01 - Why food restriction works for weight loss but fails for maintenance 24:04 - The role of dietary protein and resistance training in weight loss 30:17 - How small changes in energy balance lead to big results 35:07 - Why 150 minutes of exercise per week isn’t enough to maintain weight loss 41:55 - Why most people regain weight after stopping GLP-1 medications 48:00 - How metabolic flexibility influences weight control 52:47 - The importance of tracking body composition over time 1:02:00 - Why exercising your metabolism is key to long-term success 1:09:14 - The underestimated role of mindset in weight management 1:18:27 - The future of obesity treatment: personalized approaches Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

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In this episode, I sit down with Dr. Elizabeth Yurth, MD, ABPMR, ABAARM, FAARM, FAARFM, FSSRP. renowned as one of the brightest minds in regenerative and longevity medicine. We discuss the concept of “biohacker syndrome,” exploring why more supplements aren’t always better, as well as diving into cutting-edge therapies like GLP-1 agonists and rapamycin. Dr. Yurth unpacks the myths around cholesterol and NAD, clarifies the hype on biological age tests, and shares how bone health is often overlooked yet essential to long-term vitality. Throughout our conversation, she emphasizes that true longevity relies on balancing the right interventions, not just piling them on. We also talk about the critical interplay between muscle and bone: why osteoporosis and sarcopenia go hand in hand, and how resistance training remains a cornerstone of healthy aging. From exploring repurposed drugs (like Telmisartan and Cialis) for broader health benefits to understanding why low-dose NAD or antioxidants might be better than high-dose regimens, Dr. Yurth’s insights reflect her deep research background. If you’re looking to sift through the confusion of trendy protocols and focus on science-backed, personalized approaches, this conversation is for you. #EsraÇavuşoğlu #AyıkKafa #ElevatingLifeEvolvingHealth #Longevilab #DrElizabethYurth #Biohacking #boulderlongevityinstitute Dr. Elizabeth Yurth: Website: https://boulderlongevity.com/about/dr-elizabeth-yurth/ Instagram: https://www.instagram.com/dryurth?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw== *To subscribe to our channel 👉* https://www.youtube.com/@ayikkafa *Dr. Esra Çavuşoğlu, PhD* Instagram: https://www.instagram.com/esracavusoglu/ https://www.instagram.com/longevilab Web: https://www.longevilab.com/hakkimizda#esra-cavusoglu *To Reach Us 👉* [email protected] *About Ayık Kafa* Dr. Esra Çavuşoğlu, PhD, took her studies, starting from her personal treatment experiences and continuing with her clinical psychology education, to the next level by completing her PhD focused on Addiction. Dr. Esra in Ayık Kafa podcast discusses the world’s latest technologies, protocols, products and research in the fields of Biohacking and Longevity, while sharing first-hand information and experiences about the Disease of Addiction, as well as her latest academic studies. *About Dr. Esra Çavuşoğlu, PhD* Longevilab's founder, Dr. Esra, is a United States and internationally trained clinical psychologist and a certified addiction therapist in New York. She served as International Development Advisor on the Yale University Faculty of Medicine Clinical Advisory Board. She is the founder and supervisor of Gaziantep Oya Bahadır Yüksel Rehabilitation Center, Dr. Esra is the designer and implementer of the Turkey Rehabilitation Model. Dr. Esra founded the Contemporary Addiction Studies Association (ÇABAÇAD) in order to combat Turkey's growing addiction problem.

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Learn more about the First Ever Ketogenic Pre Workout by BPI Sports. Best Pre Workout™: http://bit.ly/best-pre BPI Sports co-founder James Grage discusses the sports supplements company’s (latest) first ever ketogenic pre-workout formula called Best Pre Workout™. If you’re following a ketogenic diet or a low-carb diet or doing intermittent fasting or fasted cardio, Best Pre Workout™ can help energize your body so you can have better workouts, and fuel your body toward fat loss goals. James Grage discusses the various ingredients in the first ever ketogenic pre-workout formula starting with medium chain triglycerides or MCTS, stating that your body will use them as a source as fuel (as you eat less carbs). Best Pre Workout™ will also help you fight that mental fogginess people experience when on a low-carb diet also a symptom that’s typically part of the keto flu. Keep watching to understand how the metabolic shift of a ketogenic diet works and how Best Pre Workout™ can help support your efforts thanks to BHB salts to balance electrolytes and more.