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📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com and/or 📢 Become an Insider, Ben’s website: https://www.benbikman.com In this Metabolic Classroom lecture, Ben challenges the conventional insulin-centric model of type 1 diabetes by introducing the “bi-hormonal hypothesis” proposed by Dr. Roger Unger. While insulin deficiency is a defining feature of T1DM, Dr. Bikman emphasizes the overlooked role of glucagon in driving hyperglycemia, ketone production, and muscle wasting. In normal physiology, insulin from beta cells locally suppresses glucagon from alpha cells. But in type 1 diabetes, this local regulation is lost, allowing glucagon to run unchecked—even when blood glucose is high. Ben explains how injected insulin, although lifesaving, can’t mimic the precise intra-islet insulin levels needed to suppress glucagon secretion. This mismatch helps explain why blood sugar control can remain elusive despite appropriate insulin use. Excess glucagon ramps up liver glucose output and ketogenesis, creating a more complex hormonal storm than insulin alone can calm. The lecture also explores new therapeutic strategies—including glucagon receptor blockers and GLP-1 agonists—that may help suppress glucagon more effectively. Dr. Bikman urges a shift in perspective: instead of seeing diabetes as just a disease of insulin, it’s time to recognize its bi-hormonal nature and tailor treatment accordingly. Show Notes/References: For complete show notes and references, we invite you to become an Insider subscriber. You’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben after the lecture, ad-free podcast episodes, show notes and references, online Office Hours access, Ben’s Research Review Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more: https://www.benbikman.com Translation Notes: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) In addition, our channel has first access to YouTube’s new, innovative “auto-dubbing” feature. The process currently supports translations from English into many languages, with more to come. Click on the gear icon, then choose “Audio track” to access. #Type1Diabetes, #T1DM, #InsulinResistance, #Glucagon, #RogerUnger, #DiabetesScience, #MetabolicHealth, #BloodSugar, #Ketones, #DiabetesEducation, #InsulinTherapy, #Endocrinology, #DiabeticKetoacidosis, #DiabetesTreatment, #DiabetesResearch, #MetabolicDisorders, #GlucoseControl, #BetaCells, #AlphaCells, #PancreaticHealth #keto #metabolicclassroom #benbikman #drbenbikman Timestamps (approximate): 00:01 – Rethinking the Insulin-Centric Model 01:04 – Dr. Roger Unger and the Bi-Hormonal Hypothesis 03:15 – Glucagon: The Forgotten Hormone 05:17 – Glucagon Physiology and Liver Function 08:23 – Pericrine Regulation in Pancreatic Islets 10:36 – What Goes Wrong in Type 1 Diabetes 12:45 – Glucagon Secretion Without Insulin 13:50 – Glucagon’s Role in Ketogenesis and Protein Breakdown 15:54 – The Limits of Injected Insulin 17:58 – Why Systemic Insulin Misses the Mark 19:10 – Explaining Glucose Variability and High Insulin Needs 21:34 – Clinical Implications of Hyperglucagonemia 23:32 – Muscle Wasting and Amino Acid Shuttling 24:29 – Blocking Glucagon: A Therapeutic Strategy 25:29 – Type 2 Diabetes and Glucagon Resistance 26:21 – Drug Therapies Targeting Glucagon 28:31 – GLP-1 Drugs as Glucagon Suppressors 29:37 – Final Thoughts: A Paradigm Shift in Diabetes Treatment Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15) Other products Ben likes: https://www.amazon.com/shop/benbikmanphd
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Many people struggle with weight loss and finding the right solution that works for them. The market is flooded with various products and programs promising quick results, but it can be overwhelming to figure out what actually works. Trisha, a 35-year-old marketing executive, faced the same struggle until she discovered a secret weapon that helped her slim down – weight loss gummies. These delicious gummies not only satisfied her sweet tooth but also helped her shed unwanted pounds without feeling deprived.
Trisha’s Journey to Finding Weight Loss Gummies
Trisha had tried numerous diets and exercise routines in the past, but nothing seemed to stick. She was frustrated with the lack of results and was on the verge of giving up. That’s when she stumbled upon weight loss gummies. At first, she was skeptical about their effectiveness, but after reading countless positive reviews, she decided to give them a try. To her surprise, the gummies not only tasted great but also helped curb her cravings and boost her metabolism.
Trisha started taking the gummies as directed and incorporated them into her daily routine. She noticed that she felt more energized throughout the day and didn’t experience the usual afternoon slump. As the weeks went by, she began to see visible changes in her body – her clothes were fitting looser, and she had more confidence in her appearance. Trisha was thrilled with the progress she was making and was eager to continue on her weight loss journey.
The Science Behind Weight Loss Gummies
Weight loss gummies are formulated with natural ingredients that are known to promote weight loss. These ingredients work together to suppress appetite, increase metabolism, and boost energy levels. For example, ingredients like green tea extract and garcinia cambogia are commonly found in weight loss gummies and have been shown to aid in weight loss. These gummies are a convenient and enjoyable way to incorporate these beneficial ingredients into your daily routine without the need for pills or shakes.
One of the key benefits of weight loss gummies is that they are easy to take on the go. Trisha found them to be the perfect snack or pick-me-up when she was craving something sweet. The gummies helped her stay on track with her weight loss goals without feeling deprived. Additionally, the gummies are easy to incorporate into any lifestyle, whether you’re at home, work, or on the go. They can be taken anytime, anywhere, making them a convenient option for busy individuals like Trisha.
Tips for Incorporating Weight Loss Gummies into Your Routine
If you’re considering trying weight loss gummies, here are some tips to help you incorporate them into your routine:
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3. Stay hydrated throughout the day to help the gummies work effectively. Drinking plenty of water will aid in digestion and keep you feeling full and satisfied.
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Trisha’s journey to slimming down with weight loss gummies has been a game-changer for her. She has found a solution that works for her lifestyle and has helped her achieve her weight loss goals. If you’re struggling to lose weight and are looking for a simple and effective solution, consider giving weight loss gummies a try. With the right mindset and consistency, you can achieve the results you desire just like Trisha did.
Remember, everyone’s weight loss journey is unique, so it’s essential to find what works best for you. Whether it’s weight loss gummies, a new exercise routine, or a different diet plan, the most important thing is to stay committed and be patient with yourself. With determination and the right tools, you can reach your weight loss goals and feel confident in your body.
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In recent years, the weight-loss industry has seen a surge in innovative products, with one of the latest trends being fat burner gummies. These chewable supplements have garnered attention for their convenience and effectiveness in aiding weight loss. While traditional weight-loss methods such as dieting and exercise remain crucial, fat burner gummies offer a new and enticing approach to shedding unwanted pounds. Let’s dive into the rise of fat burner gummies and explore how they are changing the game in the weight-loss arena.
The Evolution of Fat Burner Gummies
Fat burner gummies have quickly gained popularity as a convenient and tasty way to supplement weight-loss efforts. These gummies are typically formulated with ingredients such as green tea extract, caffeine, and Garcinia Cambogia, known for their potential to boost metabolism and promote fat burning. Unlike traditional weight-loss pills, fat burner gummies offer a more palatable option that can be easily incorporated into daily routines. With flavors ranging from fruity to tangy, these gummies have become a preferred choice for those seeking an alternative to traditional weight-loss supplements.
One of the key factors driving the success of fat burner gummies is their accessibility. These supplements are widely available online and in stores, making them easily obtainable for consumers looking to jumpstart their weight-loss journey. Additionally, the convenience of fat burner gummies makes them a practical choice for individuals with busy lifestyles who may struggle to adhere to strict diet and exercise regimens. By simply popping a few gummies a day, users can enjoy the benefits of these supplements without added hassle.
Another appealing aspect of fat burner gummies is their natural ingredients. Many brands focus on using plant-based and organic components in their formulas, appealing to health-conscious consumers seeking clean and transparent products. This emphasis on natural ingredients sets fat burner gummies apart from synthetic weight-loss supplements, offering a more wholesome option for those looking to support their weight-loss goals without compromising on quality.
The Science Behind Fat Burner Gummies
While fat burner gummies may seem like a novel concept, the science behind them is rooted in well-established principles of weight loss. The key ingredients in these supplements work synergistically to promote fat metabolism, increase energy expenditure, and suppress appetite. For example, green tea extract is rich in antioxidants called catechins, which have been shown to aid in fat oxidation and improve metabolic function. Similarly, Garcinia Cambogia contains hydroxycitric acid, which may help curb cravings and prevent excess fat storage.
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Furthermore, the addition of caffeine in fat burner gummies can enhance thermogenesis, the process by which the body generates heat and burns calories. By stimulating the central nervous system, caffeine can increase energy levels and promote fat mobilization, making it a popular ingredient in weight-loss supplements. When combined with other synergistic compounds, such as L-carnitine and B vitamins, fat burner gummies can provide a comprehensive approach to supporting weight-loss goals.
Research on fat burner gummies is still emerging, but preliminary studies suggest promising results. Clinical trials have shown that certain ingredients commonly found in fat burner gummies, such as green tea extract and Garcinia Cambogia, may effectively aid in weight loss when used in conjunction with a healthy diet and regular exercise. While individual results may vary, the science behind fat burner gummies offers a compelling case for their role in supporting a holistic approach to weight management.
The Future of Fat Burner Gummies
As the demand for innovative weight-loss solutions continues to grow, the future of fat burner gummies looks bright. With advancements in formulation and efficacy, these chewable supplements are poised to become a staple in the weight-loss industry. Manufacturers are increasingly focusing on developing new flavors, textures, and ingredient combinations to cater to diverse consumer preferences, making fat burner gummies a versatile and customizable option for individuals seeking personalized weight-loss support.
Additionally, the rise of fat burner gummies has sparked interest in the broader field of nutraceuticals, which encompasses dietary supplements derived from natural sources with purported health benefits. These supplements are becoming increasingly popular as consumers prioritize wellness and seek alternative approaches to traditional medicine. Fat burner gummies represent a fusion of science and nature, offering a modern solution to age-old concerns about weight management.
Overall, fat burner gummies are emblematic of the ongoing evolution of the weight-loss industry, where innovation and consumer-centric products take center stage. Whether you’re looking to kickstart your weight-loss journey or enhance your current regimen, fat burner gummies offer a flavorful and effective option for achieving your goals. With their convenience, natural ingredients, and science-backed benefits, fat burner gummies are setting a new standard for weight-loss supplements in a market that is constantly evolving.
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The keto diet has been gaining popularity in recent years for its ability to help individuals lose weight and improve overall health. One of the challenges of the keto diet is finding tasty snacks that fit within the guidelines of the diet. Keto Fitastic Gummies are a delicious and convenient way to enjoy a sweet treat while staying in ketosis.
What are Keto Fitastic Gummies?
Keto Fitastic Gummies are sugar-free gummy candies that are specially formulated for individuals following a ketogenic diet. These gummies are made with high-quality ingredients that are low in carbs and sugar, making them the perfect guilt-free snack for keto dieters. Each serving of Keto Fitastic Gummies contains a blend of exogenous ketones and other key nutrients to support fat burning and energy levels.
These gummies come in a variety of flavors, including raspberry, lemon, and orange, making it easy to satisfy your sweet tooth without derailing your diet. Whether you’re looking for a quick snack on the go or a treat to enjoy after a meal, Keto Fitastic Gummies are a delicious and convenient option for keto dieters.
How do Keto Fitastic Gummies work?
Keto Fitastic Gummies work by providing your body with a source of exogenous ketones, which can help jumpstart ketosis and support fat burning. When you’re following a ketogenic diet, your body enters a state of ketosis, where it burns fat for fuel instead of carbs. Exogenous ketones are a supplemental source of ketones that can help your body stay in ketosis and burn fat more efficiently.
In addition to exogenous ketones, Keto Fitastic Gummies also contain other key nutrients like MCT oil and collagen, which can help support energy levels, muscle recovery, and overall health. By incorporating these gummies into your daily routine, you can enjoy the benefits of the keto diet while satisfying your cravings for something sweet.
Benefits of Keto Fitastic Gummies
There are several benefits to incorporating Keto Fitastic Gummies into your keto diet. First and foremost, these gummies are a convenient and delicious way to enjoy a sweet treat without consuming excess carbs and sugar. With only a few net carbs per serving, Keto Fitastic Gummies are a guilt-free option for satisfying your sweet tooth.
Additionally, the exogenous ketones and other key nutrients in Keto Fitastic Gummies can help support fat burning, energy levels, and overall health. Whether you’re looking to lose weight, increase your energy, or improve your athletic performance, these gummies can help you reach your goals while following a ketogenic diet.
How to incorporate Keto Fitastic Gummies into your diet
There are many ways to enjoy Keto Fitastic Gummies as part of your ketogenic diet. You can eat them as a standalone snack, enjoy them with a meal, or even use them as a topping for yogurt or ice cream. These gummies are versatile and can be enjoyed in a variety of ways to suit your cravings and dietary preferences.
For optimal results, it’s recommended to limit your intake of Keto Fitastic Gummies to one or two servings per day, depending on your individual needs and goals. It’s also important to continue following a balanced ketogenic diet and staying hydrated to support your overall health and wellness while enjoying these delicious gummies.
Are Keto Fitastic Gummies right for you?
If you’re following a ketogenic diet and looking for a tasty and convenient snack to enjoy while staying in ketosis, Keto Fitastic Gummies may be the perfect option for you. These gummies are made with high-quality ingredients and are specifically formulated to support fat burning and energy levels on the keto diet.
Whether you’re new to the keto diet or a seasoned veteran, Keto Fitastic Gummies can help you stay on track with your goals and enjoy a sweet treat without compromising your progress. With their delicious flavors and satisfying texture, these gummies are sure to become a staple in your keto routine.
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