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Altimmune’s experimental weight loss drug pemvidutide minimized the loss of muscle mass while losing weight, mimicking the effects of diet and exercise, according to the results of a small trial by the company, amid efforts by biotech firms to study how increasingly popular weight-loss drugs can maintain muscle mass. Other popular weight-loss drugs have been studied for their ability to maintain muscle mass while helping patients lose weight. During a 68-week trial of semaglutide, the active ingredient in Ozempic and Wegovy, over 1,300 participants using the drug lost an average of nearly 15 pounds of lean muscle and 23 pounds of fat. BioAge Labs announced last year it would be testing its muscle loss drug azelaprag with Mounjaro to treat obesity, after an early trial indicated azelaprag could help prevent muscle atrophy. Additional data from Altimmune’s mid-stage trial will be presented at an unspecified upcoming event, the company said. Results from a study involving pemvidutide’s treatment of MASH are expected in the first quarter of 2025. All data is taken from the source: http://forbes.com Article Link: https://www.forbes.com/sites/tylerroush/2024/03/27/what-to-know-about-permvidutide-altimmune-says-weight-loss-drug-minimized-muscle-mass-loss-in-trial/ #newscnn #newstodayupdate #newstodayabc #bbcworldnewstoday #usanewstoday #newsworldtoday #
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O melhor exercício para perder BARRIGA! Sim, o agachamento é um dos melhores exercícios pra ajudar a perder barriga — e eu te explico detalhe por detalhe como fazer um agachamento perfeito nessa aula do meu canal no YouTube.
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Transformative Weight Loss with GLP-1 Medications: Side Effects, Tips & Personal Journeys In this episode of The Downsized, hosts Laraine and Christopher Durham share their transformative weight loss journeys totaling over 130 pounds through GLP-1 medications, including compounded tirzepatide, Mounjaro, Zepbound, Ozempic, and Wegovy. They provide candid insights into managing side effects such as nausea, constipation, diarrhea, dry mouth, and fatigue, with practical advice on diet adjustments and side effect management. The couple emphasizes that they are not medical professionals, but their personal stories highlight the significant benefits and emotional challenges of using these medications. They delve into topics like the impact on taste and food perception, financial implications, and overall improvement in health markers such as blood pressure and physical activity levels. The episode, recorded in their backyard with charming cameos from their cat Jojo and a visiting hawk, aims to provide valuable information and encouragement to those considering or already using GLP-1 medications for weight loss. Through honest discussion and reflective anecdotes, Laraine and Christopher offer viewers a comprehensive look at the life-changing potential of these treatments, emphasizing the importance of consulting healthcare providers and maintaining open communication with trusted individuals throughout the journey. DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. 00:00 Welcome to The Downsized 00:11 Discussing GLP-1 Side Effects 01:25 Our Weight Loss Journey 01:53 Experiences with Different Medications 02:42 Managing Side Effects 05:57 Travel and Medication 16:49 Diet and Eating Habits 22:03 Weekly Weight Loss Journey 22:37 Impact of Weight Watchers 23:23 Managing Medication Side Effects 24:13 Concerns About Long-Term Side Effects 26:05 Addressing Muscle Loss 27:57 Cost of Medication 32:49 Sustainable Eating Habits 37:04 Advice on Managing Side Effects 39:37 Importance of Doctor Support 42:16 Final Thoughts and Recommendations
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On today’s episode of Live Lean TV, I’m sharing 7 reasons why you can’t lose weight. How many of these fat loss mistakes are you making? 👉 Join Team Live Lean: https://bit.ly/3DtdwX9 👉 Free 7 Day Meal Plan And Recipes: https://bit.ly/3BhxjGE 👉 Live Lean Body Quiz: https://bit.ly/3BJlF8N Timestamps: 00:00 7 Reasons Why You Can't Lose Weight 00:45 Your Portion Sizes Are Whack 01:36 You’re Drinking Your Calories 02:11 You’re Eating Fattening “Health” Foods 02:38 You Watch Too Much TV 03:17 Alcohol Is Getting The Better Of You 03:39 Your Cheat Meals Are Turning Into Cheat Weeks 03:55 You Think You Can Out Exercise A Bad Diet If you think you’re doing everything you can, but you’re still not seeing any weight loss results, I’d be willing to bet you’re guilty of at least one of the following 7 reasons why you can’t lose weight. #1. Your Portion Sizes Are Whack More than likely, your portion sizes are much larger than they need to be. Next time you’re having cereal, measure the actual portion size listed on the nutrition label. I’ll bet your regular portion size of cereal, and the sugary dairy milk, is probably 2-3 times the recommended serving size on the label. If this is the case, it may make sense for you to dust off the food scale, and go back to the school of calorie counting for just 3-4 weeks, as a refresher. #2. You’re Drinking Your Calories Most of the time drinking your calories is a nasty habit, especially when those calories are nothing more than sugar. This overconsumption of sugar triggers your hunger and cravings even more. Focus only on hydrating with zero calorie natural drinks, such as water, tea, and coffee. A lot of the artificially sweetened zero calorie “diet” drinks have been shown to spike hunger. #3. You’re Eating Fattening “Health” Foods Just because a food label on the package says any of the following terms, it doesn’t mean it’s necessarily healthy: - Healthy - Natural - Low fat - Low sugar - High in fiber - High in protein Usually these processed and refined “health” foods are filled with hunger inducing chemicals and processed sugar. Next time you reach for your “healthy” yogurt, read the ingredients list and check out the sugar and fructose content. #4. You Watch Too Much TV Watching TV not only makes you snack more, you’re often not even aware of how much you’re actually eating while watching. If you are going to eat in front of the TV, always put your snack into a portion sized bowl, and stop once the bowl is empty. #5. Alcohol Is Getting The Better Of You Even if you think you’re consuming low calorie vodka and waters, when you’re consuming alcohol, you’re more than likely also snacking on party foods, such as potato chips, crackers, and dip. Also, if you’re waking up the next day hungover, more likely than not, you’re not going to hit the gym or feel like eating healthy. #6. Your Cheat Meals Are Turning Into Cheat Weeks I enjoy a weekly cheat meal, but I am also very disciplined to keep it to just that. If your cheat meals are turning into cheat weeks, it’s best for you to avoid them until you get a little more disciplined. #7. You Think You Can Out Exercise A Bad Diet The workouts you are doing are probably not burning as many calories as you think. In other words, you cannot out train a bad diet. Why else do you think so many gym rats are still overweight? These Are The 7 Reasons Why You Can’t Lose Weight If you’re not seeing the weight loss results you think you deserve, I hope this reality check really opens up your eyes. As you begin to get closer to your weight loss goals, it becomes more challenging to keep the body burning fat for fuel. Full Blog Post: https://bit.ly/3QMDLuV Subscribe Here! http://bit.ly/SubLiveLeanTV Check Out Our Top Videos! http://bit.ly/LiveLeanTVTopVideos WANT MORE DAILY TIPS ON HOW TO LIVE LEAN?: ✔ INSTAGRAM: http://www.instagram.com/bradgouthro ✔ INSTAGRAM: http://www.instagram.com/JessicaGouthroFitness ✔ INSTAGRAM: http://www.instagram.com/LiveLeanTV ✔ SNAPCHAT: http://www.snapchat.com/add/bradgouthro ✔ FACEBOOK: http://www.facebook.com/LiveLeanTV ✔ TWITTER: http://www.twitter.com/bradgouthro ✔ TWITTER: http://www.twitter.com/LiveLeanTV ✔ TIK-TOK: https://www.tiktok.com/@bradgouthro ✔ TIK-TOK: https://www.tiktok.com/@LiveLeanTv #FatLoss #WeightLoss #LiveLeanTV About Live Lean TV: Welcome to Live Lean TV. The online fitness and nutrition show, hosted by Brad and Jessica Gouthro, teaching you how to LIVE THE LEAN LIFESTYLE 365 days a year. Watch hundreds of fat blasting & muscle building workouts, easy and delicious recipes, as well as fitness and nutrition tips to get you your dream body (and maintain it 365 days a year). Make sure you click the SUBSCRIBE button for new fitness and nutrition episodes every week! Business Enquiries: [email protected] 7 Reasons You Can't Lose Weight | LiveLeanTV https://www.youtube.com/watch?v=eDHPWig7IHA Live Lean TV http://www.youtube.com/LiveLeanTV
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How does berberine work? Berberine is a bioactive compound found in various plants including barberry and goldenseal. One of the supplement’s main functions is to trigger an important enzyme, AMPK (activated protein kinase), that controls your metabolism, the process in which your body turns what you eat and drink into energy. Berberine can slow down digestion and make you feel full sooner. The supplement also makes your cells more sensitive to insulin to move glucose from your bloodstream into your cells where it’s used for energy. The better your glucose is controlled, the better chances you have of losing weight. How much weight can you lose on berberine? It’s unclear. There have been clinical studies, but there aren’t enough of them to say with certainty how much weight people will lose when taking berberine. Some studies show modest weight loss — between 5% and 7% of body weight. So, for example, if you weigh 150 pounds, you can expect to lose up to 10 1/2 lbs. If your goal is to shed some pounds and you decide to try berberine, it’s also necessary to make other dietary changes as well to ensure you’re getting enough nutrients, such as fiber and protein. Exercising regularly is important, too. Does berberine reduce belly fat? No, it doesn’t specifically reduce belly fat. No supplement trims your belly fat. A lot of noise out there on social media would have you believe there are pills you can take to trim down your belly fat, that fat is best eliminated through diet, exercise, regular sleep and reducing your stress. Berberine can lower blood glucose levels Berberine can improve your body’s ability to respond to insulin, the hormone your pancreas produces that allows your body’s cells to absorb glucose broken down from what you eat and drink, and turn it into energy. Sometimes people can become insulin-resistant. That’s when their cells aren’t responding as well to insulin as they used to. As a result, glucose isn’t entering the cells as much as it had been. When less glucose is taken up by the cells and used as energy, the glucose remains in your blood, leading to higher blood glucose levels. Metformin vs. berberine The medication metformin is currently the gold standard for helping people bring down high blood glucose levels. Berberine can also help your body respond to insulin better, but not likely as well as metformin. Taking metformin, you would typically see a faster and more significant decline in your A1C hemoglobin levels — your blood glucose levels averaged over a period of three months. If you’re taking berberine, you likely won’t see a decline in your A1C until three to six months after you begin taking the supplement. Is berberine safe to take daily? Berberine is safe to take every day. Still, it’s best to always talk with your health care provider before trying berberine or other supplements. Berberine has a half-life of several hours, so it doesn’t last in your system very long. Most berberine supplements contain 500 mg per capsule, and supplement labels often recommend taking berberine three times per day, before meals. Taking two to three capsules throughout the day would total 1,000 to 1,500 mg of berberine. Berberine is not meant to be taken with food. Take it before or in between meals, early in the day, rather than at night. Don’t take berberine if you’re pregnant, breastfeeding or under 18. Side effects of berberine Side effects of berberine aren’t common, and the benefits of the supplement typically outweigh side effects. Still, anyone considering taking berberine should first ask their health care provider. Main side effects of berberine: Gas Constipation Nausea Diarrhea A rare side effect of berberine is liver toxicity. Berberine can interact with some medications, including statins, anti-tumor medications and pain relievers such as acetaminophen (Tylenol), blood thinners such as warfarin or medicines that cause drowsiness or sedation. You need to be cautious if you’re also taking a potentially toxic medicine such as cyclosporine. Can you take berberine long-term? There’s little data on using berberine long-term. That’s true of other supplements as well, which is why some practitioners recommend taking periodic breaks from supplements. One approach may be to start by taking berberine for three months, then have your blood tested to see if your A1C went down and check your weight again. Some people will benefit from short-term uand others will see the benefits of continuing berberine supplementation over time. The bottom line Consider berberine an option for you to lose some weight and reduce your blood sugar levels. Sometimes, a supplement such as berberine is effective until it isn’t. In that case, you may have to take medication such as a GLP-1 or metformin to meet your goals. #lossweight #fatloss #caloriecounter #calorieburningworkout
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