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Welcome to another insightful episode of Midlife Unleashed! Today, we're diving into the exciting and at times controversial world of GLP1 medications, hailed by some as a weight-loss game-changer. Our host, Doug Dorsey, the fitness professor, discuss the buzz around medications like Ozempic, Wegovy, and Mounjaro. We'll explore their powerful impact on the weight-loss industry, backed by science, but not without controversy. Doug, with his extensive experience working with patients, shares intriguing insights into how these medications function beyond merely suppressing appetite. We'll unpack their roles in regulating blood sugar, enhancing insulin sensitivity, and improving metabolic health. Furthermore, we'll address the importance of proper medical supervision and lifestyle changes to ensure safe and sustainable weight loss journeys. Whether you're curious about the science behind these medications or seeking guidance on their safe use, this episode promises to be a game-changer in its own right. So, tune in as we unravel the myths, truths, and potential these medications hold for millions navigating their weight-loss journeys in midlife. Timestamps: 00:00 "GLP1 Medications: Weight Loss Revolution" 03:12 Balanced Approach to Muscle Loss Management 08:28 Insulin's Extensive Health Benefits 09:48 Lilly & Novo's Broad Health Research 15:28 Risks of DIY Weight Loss Advice 18:27 Comprehensive Health Consultation Benefits 19:59 Client Intake and Health Management 24:08 Diverse Weight Loss Experiences 26:55 Medication-Free Weight Loss Possible 32:45 Goal Attainment Before Medication Adjustment 34:42 Controlled Weight Loss Management Advice 37:34 Repeated Habits Reverse Weight Loss 43:04 Eating Challenges on Medication 45:33 "Zepbound/Mounjaro Outperform Wegovy/Ozempic" 48:40 "Medication for Weight Loss: Not Cheating" 49:46 Medication Use in Lifestyle Success 53:02 Comprehensive Weight Loss Guidance 56:48 "GLP1 Guidance and Expertise" Quotes, Hooks, & Timestamps: "The Broader Benefits of Medication Beyond Appetite Suppression": "And then with some of the cardiovascular markers, it's pretty impressive. I mean, I think the medication has been approved for people who have had heart disease and certain other heart issues. And so, you know, calling this an appetite suppressant is a little bit, I don't want to say naive, but it's not giving it its full due." — Doug Dorsey [00:08:46 → 00:09:09] "Dangers of Unverified Weight Loss Advice on Social Media": "And people are going online and TikTok and social media. And they're getting their advice not from a medical professional, but somebody who has experienced weight loss and is saying this is the way you do it when they've got a completely different body and you don't even know what their situation is." — Doug Dorsey [00:15:33 → 00:15:53] "Ensuring Qualified Medical Screening in Weight Loss Clinics": "You got someone who's been working with these medications since before they were popular, who's actually doing the screening." — Doug Dorsey [00:17:39 → 00:17:46] The Importance of Comprehensive Medical Consultations: "I think the first thing is you gotta have the person who's qualified who can ask the question and follow up questions related to where you are with your health and then making sure that they're doing and they have the knowledge to do what's in your best interest." — Doug Dorsey [00:19:21 → 00:19:38] "Comprehensive Health Planning": "We go through all of this information and I kind of build a customized nutrition plan for them. But we use that as the starting point and we can chart their process all along." — Doug Dorsey [00:20:39 → 00:20:51] "Individualized Weight Loss Journey": "There's no stress that we put on people to lose at a certain time. What we do is we emphasize the importance of following the guidelines that we provide and actually building healthy habits." — Doug Dorsey [00:22:40 → 00:23:31] Managing Weight Loss: "People gain the weight back when they just jump off. People gain the weight back when they don't do the work, meaning that they haven't learned how to live a healthy lifestyle." — Doug Dorsey [00:35:39 → 00:35:51] "Trusting the Experts: 'Which medication you should use based on your health history and based off of your blood work, that has to be done with a medical professional who's knowledgeable to make sure you get rolling and you're on the right track.'" — Doug Dorsey [00:47:19 → 00:47:35] "Rethinking Weight Loss and Medication Myths": "If somebody's experiencing perimenopause or menopausal weight gain, who takes medication to kind of help support their journey or for losing that weight is cheating, right? And I don't know why." — Doug Dorsey [00:48:48 → 00:49:03] Midlife Unleashed Show Website - https://midlifeunleashedshow.com/ Doug Dorsey's Clinic's Website - https://ctmedweightloss.com/ TopHealth Media Website - https://tophealth.care/

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Gear, Growth, and Gains Ep. 014 Peptide Reconstitution Demystified, Emerging Data on Combined GLP-1 Agonists and Myostatin Inhibitors, Oral Steroids and the Heart, and Coach's Corner - Training Volume Myths Show Time 32 min, 26 sec Show Notes and Description In episode 14 of "Gear Growth and Gains," Type-IIx discusses evidence-based practices in enhanced bodybuilding. He debunks myths about peptide reconstitution, emphasizing normal saline as the optimal solvent. The episode reviews emerging clinical data on combining GLP-1 agonists with myostatin inhibitors for improved muscle retention during weight loss. Type-IIx explains why oral 17 alpha-alkylated steroids pose greater cardiovascular risks than injectables due to their effects on lipid metabolism. Finally, he clarifies that excessive training volume impairs hypertrophy, stressing the importance of quality, intensity, and recovery for muscle growth. Outline and Timestamps Introduction and Episode Overview (00:00:30) Type-IIx introduces the podcast, outlines the four main topics, and provides disclaimers and promotional info. Peptide Reconstitution: Myths and Best Practices (00:02:56) Explains misconceptions about peptide reconstitution, debunks bro science, and emphasizes normal saline as the best solvent. History of Bro Science in Peptide Use (00:04:07) Describes the origins of peptide reconstitution myths in early bodybuilding forums and how misinformation spread. NAD+ and Solvent Confusion (00:06:33) Discusses the rise of NAD+ injections, their ineffectiveness, and confusion about which solvents to use. Normal Saline vs. Bacteriostatic Water (00:08:02) Clarifies why normal saline is preferred for reconstitution, and addresses misconceptions about bacteriostatic water. Properties and Safety of Normal Saline (00:09:05) Explains what normal saline is, its isotonic properties, and why it’s safe and widely used. Risks of Bacteriostatic Water and Solvent Regulation (00:10:24) Compares the risks of homemade bacteriostatic water to normal saline and explains regulatory reasons. GLP-1 Agonists and Myostatin Inhibitors: New Data (00:11:32) Introduces the COURAGE trial and the rationale for combining GLP-1 agonists with trevogrumab. Strategies to Preserve Muscle on GLP-1 Drugs (00:12:38) Outlines three strategies to maintain muscle while using GLP-1 drugs, focusing on drug interventions. Myostatin Inhibitors: Mechanisms and Trials (00:13:48) Reviews the history, mechanisms, and clinical trials of myostatin inhibitors, including new combination therapies with trevogrumab. COURAGE Trial Results and Drug Synergy (00:14:59) Details the COURAGE trial’s experimental groups, results, and the synergy of combining the myostatin inhibitor trevogrumab with GLP-1 drugs. Molecular Pathways in Muscle Growth (00:15:59) Explains the molecular signaling pathways involved in muscle growth and how different drugs interact. Safety and Side Effects of Myostatin/Activin-A Inhibitors (00:16:14) Discusses the safety profile of new myostatin inhibitors like trevogrumab and the side effects of anti-activin A drugs. Oral Steroids and Cardiovascular Risk (00:17:31) Explains why 17 alpha-alkylated oral steroids like Anavar are more harmful to heart health than injectables. Mechanisms of Steroid-Induced Dyslipidemia (00:18:47) Describes how oral steroids negatively affect lipid profiles and increase cardiovascular risk. Estrogen’s Protective Role and Specific Steroid Effects (00:20:08) Covers the protective effects of estrogen on lipids and why certain steroids are harsher on the heart. Summary: Why Some Steroids Are Safer for Lipids (00:21:20) Summarizes why Dianabol is less harsh on lipids and why Trenbolone is still risky despite being injectable. Book Promotion: Bolus Guide (00:21:20) Promotes the Bolus guide for practical bodybuilding drug protocols and research interpretation. Bloodwork and Lab Testing Recommendations (00:23:07) Recommends Fitomics for blood work and explains how to sign up for lab testing and newsletters. Coach’s Corner: Training Volume Myths (00:24:10) Explains why more sets, reps, or sessions are not better for muscle growth and can be counterproductive. Mechanisms of Hypertrophy and Recovery (00:25:25) Discusses the science of muscle growth, the importance of recovery, and the difference between strength and size. Effective Reps and Optimal Training Volume (00:26:35) Emphasizes the importance of effective reps, diminishing returns of excessive volume, and the inverse dose-response curve. Conclusion and Outro (00:26:35) Wraps up the episode and promises more regular content in the future. Topics Gear Growth and Gains, Meso-Rx, enhanced bodybuilding, peptide reconstitution, peptides, broscience, normal saline, GLP-1, trevogrumab, GLP-1 agonists, myostatin inhibitors, Courage trial, semaglutide, muscle retention, fat loss, oral steroids, cardiovascular risk, 17 alpha-alkylated steroid...Connie S Weight Loss Journey Sound Muted Due To Copyright Infringements

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