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Considering GLP-1s for Weight Loss? Find Out How to Avoid Muscle Loss or Muscle Wasting with GLP-1 Semaglutides. Thinking about using Ozempic, Wegovy, Zepbound, or Mounjaro for weight loss but not sure if they cause muscle loss or muscle wasting along with burning fat? Curious why drug companies are doubling down on clinical trials focused on preserving lean muscle in addition to fat loss like new GLP-1 medications Retatrutide and CagriSema now in trials? Before you start, it’s critical to understand how GLP-1 drugs affect lean muscle mass, especially for women over 40. Research shows up to 40% of weight lost with semaglutide can come from muscle—not just fat. And that’s a problem for your metabolism, strength, and long-term health. In this video, I break down & answer the questions: - The real risk of muscle loss on GLP-1s - Does ozempic cause muscle loss? Is semaglutide muscle wasting real? - How to tell if you're losing fat or lean mass - Why Wegovy muscle loss or Zepbound muscle loss is a big deal. - Do you lose fat or muscle on ozempic - Why this matters more during perimenopause and menopause - The strength training and protein strategies I use with women over 40 on GLP-1s - How to approach weight loss without losing what makes your body strong I don’t cover the new GLP-1 weight loss drugs in clinical trials—like Retatrutide, CagriSema, or semaglutide + myostatin blockers—in depth, but if you’re considering medications like Ozempic, Wegovy, or Mounjaro, or want to understand the risks of muscle loss and metabolic slowdown, this is where to start. As an IFBB Fitness Pro and women’s fitness coach, I’ve helped thousands of women lose fat, build muscle, and feel confident in their bodies—without extremes. ✅ What you’ll learn: Fat loss vs. muscle loss on GLP-1s Signs you’re losing strength, not just weight Protein + strength training tips for women 40+ A smarter weight loss approach with long-term results WATCH NEXT: My 5 Secrets to Get Fit Over 40 - Science Backed Hacks https://youtu.be/Wjdp1NHmjqM?si=8Xp-On7hd361IESz Overnight Protein Oats Recipe: 29g Protein for Busy Mornings https://youtu.be/W-xFOVQDsws Cover Model Ab Secret Revealed: EASY Move for a Flatter Belly https://www.youtube.com/watch?v=dxZB8h95c0Y&list=PLr_YQSGJumkOgV9TgtzlU0raLJCwNe6eq&pp=gAQBiAQB 🔥 Top 5 Fat-Burning Barbell Moves | Compound Exercises to Lose Fat! https://youtu.be/id3PfAPY1-U?si=g4F8jIyBdquR_6Zo FOLLOW ME 📩 FREE FITBODY MAGAZINE: https://fitbodymagazine.com/ ℹ️ WEBSITE: https://julielohre.com/ 🏆 COACHING: https://julielohre.com/online-personal-training/ 💪 SUPPLEMENTS: http://fitbody.com/ 🎧 PODCAST: https://julielohre.com/fitbody-podcast/ 🏋️ EXERCISE LIBRARY: https://julielohre.com/exercise-library/ 00:00 Are GLP-1s Making You Skinny Fat? 00:20 Why You Might Be Losing Muscle with Zepbound and Wegovy 01:00 Real Talk: Support, Not Shame 01:45 What Is 'Skinny Fat'? 03:00 The Hidden Problem with Muscle Loss 04:15 It’s Not Just About Looks—It’s About Health 05:30 How GLP-1 Medications Work 06:45 Research: 40% of Weight Loss = Muscle 08:00 Why This Matters More for Women Over 40 09:00 Menopause, Estrogen, and Muscle Decline 10:15 Fat Loss vs. Weight Loss—The Big Shift 11:00 Strategy 1: Strength Training Is Non-Negotiable 12:20 Strategy 2: Protein Intake Targets for Women Taking Semaglutides 13:40 High-Protein Meal Ideas for Low Appetite 14:20 Strategy 3: Prioritize Recovery and Movement 15:00 Stop Obsessing Over the Scale 16:00 What to Track Instead of Just Weight 16:50 The Bottom Line: Stay Strong, Not Just Smaller 17:30 How I Can Help You Lose Fat & Build Muscle Bikou, Athanasia, et al. “A Systematic Review of the Effect of Semaglutide on Lean Mass: Insights from Clinical Trials.” Expert Opinion on Pharmacotherapy, vol. 25, no. 5, Apr. 2024, pp. 611–619. https://pubmed.ncbi.nlm.nih.gov/38629387/ Møller, N., et al. “Changes in Lean Body Mass with Glucagon‑Like Peptide‑1‑Based Therapies.” Diabetes, Obesity and Metabolism, 2024. https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.15728 Tamborlane, W. V., et al. “Weight Loss and Body Composition Outcomes with Once‑Weekly Semaglutide.” Journal of Clinical Endocrinology & Metabolism, vol. 109, no. 3, 2022, pp. 704–713. https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.16162 https://www.drugdiscoverytrends.com/glp-1-impact-lean-mass/ Latif, Wafa, Katerina J. Lambrinos, and Rolando Rodriguez. “Compare and Contrast the Glucagon‑Like Peptide‑1 Receptor Agonists (GLP1RAs).” StatPearls, StatPearls Publishing, 27 Mar. 2023. https://www.ncbi.nlm.nih.gov/books/NBK572120/ Massachusetts General Brigham. “Preserving Lean Body Mass in Patients Taking GLP‑1 for Weight Loss.” Endocrinology Advances in Motion, 6 June 2025. https://advances.massgeneral.org/endocrinology/article.aspx?id=1601

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