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Pfizer on Friday said it would stop developing the twice-daily version of its experimental weight loss pill after obese patients taking the drug lost weight but had trouble tolerating the drug in a mid-stage clinical study. The drugmaker observed high rates of adverse side effects, which were mostly mild and gastrointestinal, among patients. A significant share of patients also stopped taking the drug in the trial."At this time, twice-daily danuglipron formulation will not advance into Phase 3 studies," the company said. But Pfizer said it still plans to release phase two trial data on a once-a-day version of the drug in the first half of 2024, which will "inform a path forward." The pharmaceutical giant will wait to see that data before deciding whether to start a phase three study on the once-daily pill, which Wall Street views as the more competitive form of the treatment. Still, the data on the twice-daily drug is a blow to Pfizer's hopes to win a $10 billion slice of the booming weight loss drug market, which CEO Albert Bourla has said could grow to $90 billion. The company is betting on a successful weight loss pill to help it rebound from plummeting demand for its Covid products and a roughly 40% share price drop this year. But investors have been pessimistic about Pfizer's potential in the weight loss drug space since the company scrapped a different once-daily pill in June and proceeded with the less attractive danuglipron. Now, Friday's data puts Pfizer even further behind the dominant players in the weight loss drug market, Eli Lilly and Novo Nordisk, which are racing to develop more convenient pill versions of their blockbuster weight loss and diabetes injections. Pfizer's phase two trial on its twice-daily pill followed around 600 obese adults who did not have Type 2 diabetes. The trial examined the drug's effect on weight loss after 26 or 32 weeks, at different dosage amounts ranging from 40 milligrams to 200 milligrams. Like Novo Nordisk's Wegovy and Ozempic, Pfizer's pill works by mimicking a hormone produced in the gut called GLP-1, which signals to the brain when a person is full. All dose sizes of Pfizer's pill showed "statistically significant reductions" in body weight ranging from 6.9% to 11.7% at 32 weeks, and from 4.8% to 9.4% at 26 weeks. Meanwhile, patients on a placebo lost 8% to 13% of their body weight at 32 weeks and 5% to 9.5% at 26 weeks, Pfizer said. The company said high rates of adverse events were observed among patients in the study, with up to 73% experiencing nausea, up to 47% vomiting and up to 25% experiencing diarrhea. More than 50% of patients across all dose sizes stopped taking the pill, compared to roughly 40% among those on the placebo, according to Pfizer. No new safety issues were observed, and danuglipron was not associated with increased liver enzymes like Pfizer's other discontinued weight loss pill. All data is taken from the source: http://cnbc.com Article Link: https://www.cnbc.com/2023/12/01/pfizer-to-discontinue-twice-daily-version-of-weight-loss-pill.html #weight #newshour #newstodayheadlines #newstodayfox #newstodayupdate #newstodayworld #

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Are you losing weight with Ozempic® or Wegovy® (semaglutide) but worried about losing muscle too? You’re not alone. GLP-1 medications are game-changers for fat loss—but without the right strategies, they can lead to unwanted muscle loss. Here are 3 science-backed tips to protect your muscle while shedding pounds: 💪 Prioritize Protein: Eat high-quality protein with every meal to support muscle maintenance and recovery. 🏋️ Incorporate Resistance Training: Strength training 2–3 times a week helps preserve lean mass, improve metabolism, and enhance overall body composition. 🔬 Stay Ahead with New Treatments: Watch for innovations like semaglutide + bimagrumab, a promising combo that targets fat loss while preserving muscle mass. Need Personalized Guidance? Find a certified medical provider near you: https://www.certifiedmedicalproviders.com/ 🎓 Healthcare professional? Expand your services with GLP-1 weight loss training through IAPAM. Learn evidence-based strategies, hands-on protocols, and grow a cash-based practice that gets real results. 👉 Start here: https://cme.iapam.com/free-cme-application-glp1-yt/ #Semaglutide #OzempicWeightLoss #WegovyResults #GLP1Tips #WeightLossWithoutMuscleLoss #protein #MusclePreservation #ProteinMatters #StrengthTraining #FitOnGLP1 #FatLossTips #IAPAMTraining #MedicalWeightLoss #WeightLossJourney #DoctorEntrepreneur #SideHustleMD #FunctionalFitness #OzempicJourney #WeightLoss2025

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Struggling with stubborn belly fat? In this video, we’ll show you the best exercises to lose belly fat fast and get a toned core. These workouts target your abs, burn calories, and speed up fat loss. Whether you're a beginner or advanced, these moves will help you see results quickly! Pair them with a healthy diet for the best outcome. Exercises Included: ✔️ High-Intensity Interval Training (HIIT) ✔️ Crunches & Leg Raises ✔️ Planks & Mountain Climbers ✔️ Cardio & Strength Training 🔥 Get ready to burn fat and sculpt your abs! Watch now and start your fitness journey today! Lose belly fat fast Best exercises for belly fat Belly fat burning workout Flat stomach exercises Home workout for belly fat HIIT for fat loss Abs workout at home Fat burning exercises Cardio for belly fat #LoseBellyFat #BellyFatWorkout #FatBurning #HomeWorkout #FitnessJourney #AbsWorkout #WeightLoss #HIITWorkout #FlatStomach #WorkoutMotivation

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The most common reason why my patients stop taking Metformin is because it tears up their stomach. Bloating, Gas, Diarrhea are the most common things that we see. It doesn't have to be this way for everybody though. There are 4 tried and true ways that you can try and avoid these side effects and be able to tolerate this important medication. Here are the steps: 00:58 - Take with Food 01:30 - Ask for Extended Release Pills 02:12 - Start Low and Go Slow! 02:53 - Avoid those Carbs! Hopefully these will help you have success taking Metforin. Thanks for watching! Learn more about our practice at: https://ridgeviewfamily.com/ ** The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/mental health professional ** All images and additional video segments contained in the Thumbnails and/or B-roll segments are used in strict compliance with the appropriate permissions and licenses required from https://pixabay.com,https://stock.adobe.com, https://storyblocks.com, https://soundstripe.com, https://elements.envato.com/ and in accordance with the YouTube Partner Program, Community guidelines & YouTube terms of service

Fat Burning Exercise Part 31exercise Yoga Weightloss Shorts

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What Are the Health Risks of Eating Biscuits | Indian Weight Loss Diet by Richa Unhealthy snacks like biscuits are a big no for your health! These sugar-loaded snacks can lead to overeating, causing motapa and obesity-related diseases such as diabetes, high blood pressure, fatty liver, migraines, and PCOS/PCOD. But don't worry! You can stay healthy and lose weight by enjoying tasty weight loss meals and steering clear of unhealthy snacks. 🍽️🚫 🌟 Want to lose up to 12 kgs in a month with the right guidance? 🌟 Start your weight loss transformation journey today: 📲 Download our app: Indian Weight Loss Diet (Available on Android & iOS) Achieve amazing fat loss and inch loss results with our guidance! ✨️ Do subscribe to our channel for more updates about your weight loss. Follow us on Instagram - https://www.instagram.com/indianweightlossdiet/ Visit our Website - https://indianweightlossdiet.com/ Download our App from Android - https://play.google.com/store/apps/details?id=com.iwldbyricha Download our App from iOS - https://apps.apple.com/in/app/indian-weight-loss-diet/id6462674579 #WeightLossTransformation #WeightLoss #FatToFit #FatLossTransformation #FatLoss #HealthyDiet #BeforeAndAfterWeightLoss #LoseWeightFast #WeightLossMotivation #WeightLossSuccess #WeightLossCoach #IndianWeightLossDiet #WeightLossChallenge

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Ständig hungrig. Frustriert. Scham nach jedem Rückfall. Und das Gefühl, dass nichts hilft – außer Aufgeben. Aber dann hat sie verstanden, was wirklich in ihrem Körper passiert. GLP-1 war der Gamechanger. Kein Wundermittel. Aber ein medizinischer Hebel, der endlich geholfen hat. Diese Geschichte ist echt. Und sie zeigt: Du bist nicht allein. Und du bist nicht schuld. 🧠💉 Wenn du dich auch fragst, ob dir die Abnehmspritze helfen könnte – mach einfach unser kostenloses Online-Screening (Link in Bio). 🔍 Medizinisch geprüft. Empathisch. Ohne Druck. Ohne Scham. 👇 Schreib mir in die Kommentare, wenn du dich darin wiedererkennst. Wir sehen dich. Und wir hören dich. ❤️ #ovellia #abnehmspritze #glp1 #körperverstehen #frauen40plus #abnehmenohnescham #hormonbalance #emotionaleseating #ovelliajourney