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In continuation of my update "Metformin" GLP-1 receptor agonists, a class of drug used to treat type 2 diabetes, likely trump the widely prescribed metformin for curbing dementia risk in people with the condition, finds the largest study of its kind, published in the open access journal BMJ Open Diabetes Research & Care. The findings suggest that future clinical guidelines for the treatment of type 2 diabetes would do well to consider prioritizing drugs with both blood glucose and neuroprotective effects, say the researchers. Published research suggests that both GLP-1 receptor agonists and metformin, which are widely used to treat type 2 diabetes, protect the brains of people with the disease. But as yet there have been no direct real-world comparisons of the potential impact of these drugs on dementia risk—a risk that is around 70% higher in people with type 2 diabetes. To explore this further, the researchers drew on anonymized electronic health records from a global health research network (Trinetx) spanning the period 2004 to 2024 to track the development of dementia in patients with type 2 diabetes, treated with either GLP-1 receptor agonists or metformin (87,229 patients in each group; average age 58) for at least six consecutive months. There was no significant difference in vascular dementia risk between the two types of drug when used as first line therapy. But GLP-1 receptor agonist use was associated with a significantly lower cumulative (10%) risk of developing dementia, overall, with an incidence of almost 2.5% (2,130 people) compared with an incidence of nearly 5% (4,215 people) for metformin. And specifically, taking this type of drug was associated with a 12% lower risk of developing Alzheimer's disease, and a 25% lower risk of developing non-vascular dementias than metformin use. Further in-depth analyses showed that these positive effects were evident across all age groups, but with the strongest effect among the over 60s, women, and those of white ethnicity. Risk of death from any cause was also lower: nearly 5% of those treated with GLP-1 receptor agonists died compared with nearly 9% of those treated with metformin. "Both medications demonstrate neuroprotective properties, such as reducing neuroinflammation and oxidative stress, improving insulin sensitivity, and enhancing cerebrovascular health, which likely contribute to their benefits in overall dementia," explain the researchers. But unlike metformin, whose benefits primarily derive from systemic metabolic effects, GLP-1 receptor agonists exert direct central nervous system effects by crossing the blood-brain barrier, they add. "However, the multifactorial nature of [vascular dementia], driven by cerebrovascular damage, such as small vessel disease and white matter lesions, poses significant challenges for pharmacological interventions targeting metabolic or neurodegenerative pathways," they continue. This is an observational study, and as such, no firm conclusions can be drawn about cause and effect. And the researchers point out that the tracking period, while sufficient for observing dementia outcomes, may not fully capture long-term cognitive effects, especially given the progressive nature of Alzheimer's disease. REF:https://www.med-chemist.com/2025/07/glp-1-diabetes-drugs-likely-trump.html

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Muscular endurance! Core stability! Stamina! Body awareness! Controlling of the dumbbell! Lots of energy! That’s what you’ll need for this workout! It’s all in this 20 minute dumbbell cardio workout! The timer will be on for 30 seconds per exercise, with 4 exercises to build each giant set! There will be no specific rest period between each giant set so it is essentially 2 minutes of work! This is not HIIT, this is moderate intensity cardio where your heart rate will be elevated for most of the workout! During HIIT, the heart rate is spiked throughout and this dumbbell cardio is more moderate level sustained throughout! This doesn’t mean any less intensity that HIIT though! It’s just as challenging just in a different way! Sweat throughout too! 😅 All you will need for this sweaty workout is a pair of dumbbells and your mat! The dumbbells I am using for your reference are 6kg each! There is no jumping in this workout as I don’t incorporate jumping with weight very often. However I do ‘hop’ back into the plank however you can simply step back into the plank if preferred! Although this is with lighter weights, it is important to treat those dumbbells with respect! Control the dumbbells at all times! SQUAT TO PRESS SQUAT SQUAT TO PRESS SQUAT SPRAWL RENEGADE ROW SPRAWL RENEGADE ROW REAR LUNGE TO SQUAT LUNGE (same side) REAR LUNGE TO SQUAT (switch) LUNGE (same side) HANDS TO FLOOR BURPEE DEADSTOP PUSH UPS HANDS TO FLOOR BURPEE DEADSTOP PUSH UPS SQUAT TO PRESS (one side) SWITCH SIDE! SWITCH SIDE! SWITCH SIDE! FRONTAL RAISE SQUAT WALKS FRONTAL RAISE SQUAT WALKS CURTSEY TO SQUAT SWITCH SIDE! SWITCH SIDE! SWITCH SIDE! SUPINE ROW CLOSE SQUATS SUPINE ROW CLOSE SQUATS It is a challenge to pace the full 2 minutes but the 30 seconds changing movement becomes very welcomed! Have fun and enjoy the sweat! Cx Always ensure you warm up before any workout. Here’s my 5 Min Warm Up Routine: https://youtu.be/c0VxUFHdYzs Today’s Optional Add-on: https://youtu.be/5bgVXyP0IIM Christmas Workout Advent Playlist: https://www.youtube.com/playlist?list=PLhu1QCKrfgPVKViubrzd6hP3ziAs60qfD Join The Caroline Girvan Community ▶ Instagram: https://instagram.com/carolinegirvan ▶ Private Facebook Group: https://facebook.com/groups/carolinegirvan My Amazon Stores ▶ My Amazon UK Page: https://amazon.co.uk/shop/carolinegirvan ▶ My Amazon US Page: https://amazon.com/shop/carolinegirvan ▶ Business Enquiries Email: [email protected] Disclaimer: If you are new to exercise or planning on embarking on a new fitness programme, you should consult your physician. This video may offer health, fitness or nutritional information and is meant for educational purposes only. This information is not meant as an alternative to seeking professional medical advice or suggested treatment. Please know that performing any exercise or programme is solely at your own risk. Disclaimer: As an Amazon Associate I earn from qualifying purchases

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