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#diabetes #weightloss #diabetesdrug Research Reveals Method to Improve Diabetes and Weight-Loss Drug Performance According to new research from the University of Michigan, a network of proteins found in the central nervous system could be leveraged to enhance the effectiveness and minimize the side effects of popular diabetes and weight-loss medications. The study, published in the Journal of Clinical Investigation, focused on two proteins, melanocortin 3 and melanocortin 4, primarily located on the surface of neurons in the brain. These proteins play a central role in regulating feeding behavior and maintaining the body's energy balance.Melanocortin 3 and 4 influence everything from sensing long-term energy stores to processing gut signals about short-term satiety. GLP-1 agonists, such as semaglutides (e.g., Ozempic) and tirzepatides (e.g., Mounjaro), have gained attention for effectively treating type 2 diabetes, obesity, heart disease, and potentially addiction. These drugs mimic a natural hormone produced by the gut when full, signaling the brain to reduce feeding behavior. In the study, researchers tested the effects of several hormones that reduce food intake in the mouse models and discovered that modifying the melanocortin system made mice more responsive to GLP-1 drugs and other hormones influencing feeding behavior. Mice treated with a combination of a GLP-1 drug and an MC4R agonist or MC3R antagonist experienced up to five times more weight loss and reduced feeding compared to those receiving only GLP-1 drugs. The researchers also measured brain activity in areas associated with nausea from GLP-1 drugs and found no increased activation when these drugs were combined with alterations to the melanocortin system. However, priming melanocortin neurons significantly boosted GLP-1 drug activation in hypothalamic feeding centers. The findings suggested that combining GLP-1 drugs with an MC4R agonist could increase the drugs' effectiveness by up to fivefold without enhancing side effects. This approach could allow patients sensitive to side effects to take lower doses or improve outcomes in those unresponsive to current dosages. Further drug development and clinical testing are needed to advance this strategy. Although this research has only been conducted in mouse models, researchers remain optimistic that the results will translate effectively to humans. "The melanocortin system is highly conserved in humans. Everything we've observed in the mouse over the past decades studying these proteins has also been found in humans, so I suspect that these results would also be translatable to patients,” said Cone, director of the U-M Life Sciences Institute Check full updates on Medical Dialogues Also check out - Medical Dialogues Academy, a renowned academic wing of Medical Dialogues - India's premier health and news online portal, proudly presents this comprehensive course tailored for healthcare professionals eager to delve into the realm of medical journalism. 🔗 Enroll Today: https://academy.medicaldialogues.in/courses/certificate-course-in-medical-journalism/ 📚 Explore More With Us: 📌 Medical Content Writing: https://academy.medicaldialogues.in/courses/medical-content-writing/ 📌 Certificate Course in Pharmaceutical Medico-Marketing: https://academy.medicaldialogues.in/courses/certificate-course-in-pharmaceutical-medico-marketing/ Join us on this enlightening journey and become a part of a community pushing the boundaries of healthcare communication and reporting. Get the latest medical and health news at medicaldialogues.in Follow us on Twitter: https://twitter.com/medicaldialogs Facebook: https://www.facebook.com/medicaldialogues/ Instagram: https://www.instagram.com/medicaldialogues LinkedIn: https://www.linkedin.com/company/medical-dialogues Website: https://medicaldialogues.in/
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In recent years, the ketogenic diet has taken the world by storm. Backed by extensive scientific evidence, the diet has proven to be helpful for weight loss, mental focus, increased energy, and a range of other purposes that not surprisingly have led to greater demands for keto-friendly foods on the market. As some entrepreneurs have relished ways to serve this growing demand for keto-friendly foods, it’s also befit some of these products to find their way on to the popular episode of Shark Tank on ABC, a reality entrepreneurial television programme where aspiring moguls pitch various products to a panel of multi-billionaire investors in the hopes of securing funding to further develop their products and expand their business.
Keto Shark: Navigating the Waters of Shark Tank’s Keto Offerings
One product that received attention on Shark Tank is Keto Shark, a line of keto-friendly snacks that claims to curb your cravings. The name is a double entendre referring to both the diet and the company’s founder, Mark Cuban, a wise entrepreneur who legitimises the project. Keto Shark sells flavoured treats such as Parmesan Cheese Crisps and Chocolate Almond Butter Cups. This is just one of many keto products that aim to fuel the increasingly explosive keto lifestyle. So, how does Keto Shark compete with the many other keto snacks out there?
In addition to all the diet books out there, another keto product that made a splash on Shark Tank is the ready-to-drink coffee Keto Coffee, which is not just a normal cup of green tea but one that’s got a splash of MCT oil and grass-fed butter, so it’s an energy-charged pick-me-up that keeps you in ketosis all day. Keto Coffee: the perfect solution for living the keto lifestyle – without the hard work – or is it? Skip to the end: There’s not enough research yet on the effectiveness of Keto Coffee – or any of these products promoted on Shark Tank – to consider them useful in staying in ketosis. You’re better off doing that the old-fashioned way.
One of Shark Tank’s most successful keto products is Keto Meal Prep, a subscription service that ships specially prepared meals to your front door (breakfast, lunch, and dinner). Less stress about meal planning, less time in the kitchen – it seems easy to continue this diet! But at what cost? And, considering that the quality of keto meals matters, are the meals really keto?
Keto Baking Mix, another keto product to land in the Shark Tank, is a baking mix that can be used to make just about any baked good, from bread to cookies to pancakes. The product is great for keto dieters – it allows them to enjoy their favourite foods without being kicked out of ketosis One of the most heated areas right now in entrepreneurship in the keto space is keto baking mixes. Are there too many of them? How do they compare? Let’s compare Keto Baking Mix versus others on the market.
At last, Shark Tank fans had a protein-rich snacking bar asset to the keto lifestyle: Keto Protein Bars have 20 grams of protein per bar, promising to keep you feeling full until your next meal. Available in flavours such as Caramel Peanut and Chocolate Chip Cookie Dough, the protein bars are convenient to fuel up on the go. But among the large selection of protein bars available, are Keto Protein Bars a good investment?
Summary and FAQ
The ascendancy of the keto diet has not been without consequence; the food and supplement market is being inundated with keto-friendly products, including several that have appeared on the reality TV show Shark Tank. There are snacks and drinks and even meal delivery services – plenty of food for keto.
Keto products are many. How is one supposed to navigate the sea of keto offerings and find the best and most useful products for your health? There is a best seller, featured on Shark Tank with answers to frequently asked keto questions. With or without the keto diet, why not learn about it and enjoy? Here is the summary of the keto products that have been featured on Shark Tank. Here are answers to common questions about the keto diet and how to lose weight ketogenically: 1. What is the keto or ketogenic diet? Above is a ketogenic meal – fat-rich meats, avocado, and broccoli. The keto diet (or ketogenic diet) is based on the idea that when your body breaks down its fat, which is its primary fuel, into ketones, something wonderful happens. Ketones are smaller energy particles that enter your cells and stimulate your physiological functions to wake up and burn more energy. The keto diet, unlike a calorie-restricted diet, helps you lose weight without depriving yourself. Not only do you burn fat, but you also feel satisfied without any feelings of hunger or weakness – at least for a while. 2. What are keto products? Keto products help you stick to the ketogenic diet. One of the reasons it is so easy to fail on any diet is that we have gone so far from natural and traditional foods that we are not only far from what is good or healthy for us. We are forgetting how to eat and take care of our bodies. It takes much more effort to cook from greens and meats than to grab a cup of coffee and yogurt. Some of the products, like the Keto Chew, the Keto Caramel, and Ketobar, resemble traditional treats that we miss on this diet like cookies, Coco and Halo bars, and snickers bars. Other products like fat bombs, the blissful Keto Kit, Primal Kitchen Foods, Quest carb-free bars help us keep up with our daily habits.
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