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Time stamps 0:30 what are ketones The 3 ketone bodies are acetone, acetoacetate and beta hydroxybutyrate Your liver makes ketones from acetyl-CoA 1:02 why does breath smell weird on keto (keto breath) 1:43 what is beta hydroxybutyrate (the best ketone for brain health) 1:55 how are ketones made (ketogenesis) Ketogenesis is the pathway that makes ketones, ketogenesis happens in your liver only Long chain fatty acids are oxidized in the mitochondria to yield acetyl-CoA (beta oxidation) In a ketogenic state / keto metabolic state the acetyl-coa is favourably directed into ketogenesis instead of the tricarboxylic acid / citric acid cycle Under normal conditions (normal carbohydrate diet / fed) the long chain fatty acids are oxidized to acetyl-coa and the acetyl-coa will then enter the tricarboxylic acid / citric acid cycle In starvation states or proper keto diets, if the TCA cycle is slowed or deplete of intermediates then the acetyl-coa enters ketogenesis Ketogenesis should only happen in extreme starvation or on true keto diets 3:13 ketogenic pathway biochemistry Enzymes essential to ketogenesis… Thiolase, HMG-CoA synthase, HMG-CoA lyase, acetoacetate decarboxylase, betahydroxybutyrate dehydrogenase 4:47 acetoacetate can be cleaved to give CO2, acetone and betahydroxybutyrate 5:37 what is BHB 6:46 how do ketones give you energy (metabolism basics) Acetyl-coa is the common entry point to the tricarboxylic acid / citric acid cycle - glucose, fatty acids and amino acids can all be metabolized into ACoA ACoA can enter the TCA cycle for complete oxidation and to yield large amounts of energy Ketogenesis is when you make ketones from ACoA in the liver, the ketones then enter circulation, travel to the brain where they are converted back into ACoA, now in your brain the ACoA enters the TCA cycle for complete and rapid oxidation thus yielding large amounts of energy 9:02 How to get into ketosis / when are you in ketosis 9:37 what happens when you are starving 10:39 what is keto diet Keto diet macro distribution 5% calories from carbohydrate 25% calories from protein 70% calories from fat 11:12 why is starvation bad for you (protein sparing effect / TCA cycle depletion) 11:59 long term fasting / prolonged fasting diets 13:40 ketosis acidifies your blood and damages organs (ketoacidosis)

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This simple homemade electrolyte drink is a natural hydrator that helps your body bounce back and burn fat! Water keeps you refreshed and supports every cell, while a pinch of sea salt restores essential minerals lost through sweat—perfect after a workout or on a hot day. Fresh lemon juice adds a burst of vitamin C to support your immune system and kickstart digestion, and a touch of raw honey gives just enough natural sweetness along with trace antioxidants. It's light, zesty, and energizing—your body will thank you with every sip. Sip smart. Burn fat. Feel your best. Add the filtered water, lemon juice, sea salt, and raw honey (if using) to a large glass or jar. Stir well until the salt and honey are fully dissolved. Add a few ice cubes if desired for a refreshing chill. Sip slowly and enjoy as a natural, fat-burning hydration boost any time of day. Subscribe now and start your wellness journey — one drink at a time! 🥤🔥 🥤 Drink to Lose https://youtube.com/@DrinktoLose 🍴 Eat to Lose https://youtube.com/@EattoLose 🍴🥤 Eat & Drink to Lose https://youtube.com/@EatDrinktoLose ⚠️ Disclaimer All content on Drink to Lose is for informational purposes only. It is not medical advice. Always consult a healthcare professional before making any changes to your diet, lifestyle, or health routine.

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The more fiber-rich foods we eat, the more we boost our natural GLP-1 activity, which positively impacts our health, appetite, satiety, and much more. New subscribers to our e-newsletter always receive a free gift. Get yours here: https://nutritionfacts.org/subscribe/. Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/using-prebiotics-intact-grains-thylakoids-and-greens-to-boost-our-glp-1-for-weight-loss and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at https://nutritionfacts.org/video/using-prebiotics-intact-grains-thylakoids-and-greens-to-boost-our-glp-1-for-weight-loss. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages; you can find yours in the video settings. View important information about our translated resources: https://nutritionfacts.org/translations-info/ https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Books: https://nutritionfacts.org/books • Shop: https://drgreger.org • Facebook: https://www.facebook.com/NutritionFacts.org • Twitter: https://twitter.com/nutrition_facts • Instagram: https://www.instagram.com/nutrition_facts_org

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