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👇 Visit The Proof website for the full show notes and supporting studies. 👇 https://theproof.com/podcast/ You’ve probably heard the claim: "If you’re lean and metabolically healthy, high LDL doesn’t matter." In low-carb circles, it’s more than a claim, it’s a permission slip to eat as much butter and bacon as you like. But is that confidence backed by science? In this solo episode, I break down the much-discussed KETO-CTA study that aimed to assess cardiovascular risk in lean individuals following a long-term ketogenic diet. With commentary from Dr. Alan Flanagan, who co-authored a formal critique of the study, we examine the actual data and how it was presented. Whether you follow keto, are concerned about your LDL, or just want clarity on cardiovascular risk, this episode cuts through the noise. What we cover: - Who are Lean Mass Hyper-Responders (LMHRs) and why they were studied - What the KETO-CTA study actually measured and why calling it a "trial" is misleading - The significance of Non-Calcified Plaque Volume (NCPV) and Percent Atheroma Volume (PAV) - Why the primary outcome data was omitted from the published paper and why that matters - ApoB levels and plaque progression: what the study showed and what it didn't - The role of exploratory vs. pre-registered outcomes in research - Problems with media coverage and misleading headlines - How this study compares to others using similar imaging methods - Why the average subject showed plaque growth 4x faster than expected - What this means for people on a ketogenic diet with elevated ApoB - The importance of responsible science communication Subscribe and stay connected: Found this episode valuable? Subscribe to The Proof on YouTube and hit the notification bell to stay updated. Listening on Spotify or Apple Podcasts? Follow the show to ensure you never miss an episode. Support the show: The best way to support the show is to use the products and services offered by our sponsors. Visit http://theproof.com/friends for exclusive discounts. If you have any additional questions you would like answered in the future, let me know in the comments. Enjoy, friends. Simon This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Head to https://38tera.com/?ref=SIMON and use code PROOF for 25% off at checkout. Bragg Bragg Organic Apple Cider Vinegar is raw, unfiltered, and naturally fermented with 100% organic apples, always with the live “Mother” in every bottle. Get 20% off your first order at https://www.bragg.com with promo code SIMON. IM8 With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on http://im8health.com/ Eight Sleep Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF for $350 off at http://eightsleep.com/theproof. Try it risk-free for 30 days, with worldwide shipping. LMNT Stay hydrated with LMNT. Get a free Sample Pack of LMNT’s most popular drink mix flavors with any purchase at http://drinklmnt.com/simon Find your favorite LMNT flavor, or share with a friend. And if you don’t like it? Full refund, no questions asked. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on http://join.whoop.com/simon. Simon Hill, MSc, BSc (Hons) - Creator of http://theproof.com/ - Host of https://theproof.com/podcast/ - Author of https://theproof.com/book/ Subscribe & Connect: - YouTube: https://www.youtube.com/c/TheProofWithSimonHill?sub_confirmation=1 - Apple Podcasts: https://podcasts.apple.com/au/podcast/the-proof-with-simon-hill/id1367773989 - Spotify: https://open.spotify.com/show/7bAIJCVgnquxXZuQCdZyTi?si=84831dc34dc9408b - Instagram: https://www.instagram.com/theproof/ - X: https://x.com/theproof - Facebook: https://facebook.com/theproofwithsimonhill - Nourish your gut with my https://theproof.com/ferments/ and download my https://theproof.com/mealplan.