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(USMLE topics) Methamphetamine: mechanism of action, short-term and long-term effects, addiction and overdose. Purchase a license to download a non-watermarked copy of this video on AlilaMedicalMedia(dot)com ©Alila Medical Media. All rights reserved. Voice by: Ashley Fleming All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition. Methamphetamine, also called meth or crystal meth, among other names, is a psychostimulant drug mainly known for its recreational use. Methamphetamine is chemically similar to amphetamine, a drug used to treat attention-deficit hyperactivity disorder, obesity and narcolepsy; but being more potent and highly addictive, methamphetamine is rarely prescribed for medical treatments. Most commonly, the drug is produced illegally, from pseudoephedrine, an ingredient in cold medicines. It can exist as white powder, pills, or bluish-white crystals, and can be consumed by swallowing, smoking, snorting, or injecting. Methamphetamine acts to increase the amount of a neurotransmitter called dopamine in the brain. Dopamine is at the basis of the brain reward pathway, which is designed to “reward” the body for important behaviors that are essential for survival, such as feeding when hungry. Engaging in enjoyable activities causes dopamine release from dopamine-producing neurons into a space between neurons, where it binds to and stimulates its receptors on the neighboring neuron. This stimulation is believed to produce pleasurable feelings or rewarding effect. Normally, dopamine molecules are promptly cleared from the synaptic space to ensure that the postsynaptic neurons are not over-stimulated. This is possible thanks to the action of dopamine-transporter, which channels dopamine back to the transmitting neuron. Methamphetamine binds to dopamine-transporter and blocks dopamine re-uptake. In addition, it can enter the transmitting neuron and trigger more dopamine release. The result is that dopamine builds-up in the synapse to a much greater amount than normal. This produces a continuous over-stimulation of receiving neurons and is responsible for the prolonged and intense euphoria experienced by drug users. At a low dose, methamphetamine stimulates the brain and can elevate mood and alertness; and by accelerating heart rate and breathing rate, it increases energy in fatigued individuals. It also reduces appetite and promotes weight loss. These seemingly “positive” effects keep users coming back for more, eventually leading to addiction and potential overdose. Long-term drug users may experience extreme weight loss, severe dental damage, and constant hyperactivity which results in anxiety, sleeping disorders and violent behaviors. Overdose takes the drug’s effects to the extreme and can cause psychosis, heart attacks, seizures, strokes, organ failures, and even death. Currently, there is no approved pharmacological treatment for methamphetamine addiction; the most effective treatments are cognitive behavioral therapies.

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Burn the Fat, Feed the Muscle __ free book, Fat Burning Secrets of the World’s Best Bodybuilders "Burn the Fat, Feed the Muscle" presents a comprehensive guide to achieving permanent fat loss and muscle gain. It challenges conventional low-calorie dieting, emphasizing the importance of combining nutrition with exercise tailored to individual body types and metabolic rates. The text stresses the need to create a calorie deficit through both reduced intake and increased activity and establish powerful goals to keep you motivated. It advocates for frequent meals, understanding macronutrient ratios, and the benefits of weight training. Additionally, the guide explores the role of cardio, supplements, and the necessity of adapting fitness plans based on progress and body feedback. The text stresses the importance of adjusting your nutrition and exercise to your unique needs to achieve long-term success in fitness. Here's a briefing document based on the provided excerpts from Tom Venuto's "Burn the Fat, Feed the Muscle": Briefing Document: "Burn the Fat, Feed the Muscle" by Tom Venuto Overview: "Burn the Fat, Feed the Muscle" by Tom Venuto presents a comprehensive system for achieving permanent fat loss. It emphasizes a holistic approach that combines proper goal setting, understanding the psychology of weight loss, adopting sustainable lifestyle habits, and mastering the science of nutrition and training. The book challenges conventional dieting, advocating instead for a focus on long-term behavioral changes and a deep understanding of how the body responds to different dietary and exercise strategies. Venuto aims to empower readers to become "fat loss experts" themselves. Key Themes and Ideas: 1. The Failure of Conventional Diets: • Venuto argues that most diets fail because they are temporary and based on severe restrictions. "A 'diet' could be defined as any temporary change in your eating behavior to help you lose weight. This entire concept is flawed." • He emphasizes that "The only way you'll ever lose fat and keep it off permanently is to adopt new habits and keep them for life." • Very low-calorie diets can trigger the body's "starvation response," leading to a slower metabolism, muscle loss, and increased fat storage. "Cutting calories backfires. The more you cut, the more your body fights to hold onto its fat stores as reducing calories signals the 'starvation response' where the body tries to 'survive' and hold onto its calorie reservoir known as fat." • "Dieting is not effective in controlling weight. You can get a temporary weight loss with a diet, but each scheme ultimately gives way to weight gain, and subsequent losses become increasingly difficult. Worst of all, you get progressively fatter on less food. Dieting actually makes you fatter!” 1. The Power of Goal Setting: • Goal setting is presented as a critical first step. "If you ignore this step – like most people do - you are destined to fail no matter what you do or how hard you try." • The book outlines an 11-step goal-setting formula. It emphasizes the importance of setting specific, measurable, attainable, realistic, and time-bound (SMART) goals. • The subconscious mind plays a vital role. "It works because it harnesses the awesome power of your subconscious mind, and your subconscious mind guides your behavior." • Visualization and affirmations are key tools for reprogramming the subconscious. "All thoughts which have been emotionalized and mixed with faith begin immediately to translate themselves into their physical equivalent." • The author presents the idea that the human brain and nervous system is a “perfect goal-striving servo-mechanism." Much like a self-guided torpedo or missile that seeks out its target and steers its way to it. • "The strangest secret in the world is that you become what you think about.” 1. Adopting a "Habit" Mindset: • The book encourages a shift from short-term "diets" to lifelong "habits." "Instead of adopting the mindset of short-term 'diets,' you must adopt the mindset of lifelong 'habits.'" • Permanent fat loss is achieved through sustainable changes in nutrition and exercise. • Depending on goals, the diet can be more or less restrictive at certain times, but a baseline of healthy eating habits should remain constant. #FatBurning #BodybuildingSecrets #FitnessModels #TomVenuto #WeightLossJourney #LeanMuscle #FatLossTips #FitnessGoals #HealthyLifestyle #WorkoutMotivation #FitnessInspiration #BodyTransformation #NutritionTips #GymLife #FitnessCommunity

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