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Extended info: News #270119 he 150106 he Alternative title:Budget airline Ryanair cuts passenger traffic goal again on Boeing delays.||| It has been reported that, US stocks soar more than 20% for second year in a row.||| OpenAI to face digital news firms of Mukesh Ambani, Gautam Adani in copyright battle. J&J to buy psychiatric drug developer Intra-Cellular for $14.6B.||| Eli Lilly CEO expects new weight loss pill to be approved next year.||| 1 million U.S. adults will develop dementia each year by 2060, study says. Check for more daily news and in Japanese, Spanish, Portguese and in other languages in our X account: https://twitter.com/NewsSrcCrawler Join our community : http://eepurl.com/izVuZI to receive daily digests in PDF from handpicked news in tech, politics, sports, crypto, markets and showbiz. We aim to deliver news which complement the story of the headline of the day We respect the privacy of our watchers, of which can be human or bot, and follow the legal guidelines by using reliable access providers for subscription to our production and digests. News Source Crawler: digests, updates and bulletins from reliable sources, to keep the minds updated, of the busy and the knowledge hungry. News videos are designed to fit all the necessary information with a simple title, prepared in English and in original language of the news source. News sources from USA, UK, Australia, Canada, France, Spain, Mexico, Brazil, Israel Middle East, China, Korea, Japan are sifted for newsworthy information, to the global citizen.

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Pfizer on Friday said it would stop developing the twice-daily version of its experimental weight loss pill after obese patients taking the drug lost weight but had trouble tolerating the drug in a mid-stage clinical study. The drugmaker observed high rates of adverse side effects, which were mostly mild and gastrointestinal, among patients. A significant share of patients also stopped taking the drug in the trial."At this time, twice-daily danuglipron formulation will not advance into Phase 3 studies," the company said. But Pfizer said it still plans to release phase two trial data on a once-a-day version of the drug in the first half of 2024, which will "inform a path forward." The pharmaceutical giant will wait to see that data before deciding whether to start a phase three study on the once-daily pill, which Wall Street views as the more competitive form of the treatment. Still, the data on the twice-daily drug is a blow to Pfizer's hopes to win a $10 billion slice of the booming weight loss drug market, which CEO Albert Bourla has said could grow to $90 billion. The company is betting on a successful weight loss pill to help it rebound from plummeting demand for its Covid products and a roughly 40% share price drop this year. But investors have been pessimistic about Pfizer's potential in the weight loss drug space since the company scrapped a different once-daily pill in June and proceeded with the less attractive danuglipron. Now, Friday's data puts Pfizer even further behind the dominant players in the weight loss drug market, Eli Lilly and Novo Nordisk, which are racing to develop more convenient pill versions of their blockbuster weight loss and diabetes injections. Pfizer's phase two trial on its twice-daily pill followed around 600 obese adults who did not have Type 2 diabetes. The trial examined the drug's effect on weight loss after 26 or 32 weeks, at different dosage amounts ranging from 40 milligrams to 200 milligrams. Like Novo Nordisk's Wegovy and Ozempic, Pfizer's pill works by mimicking a hormone produced in the gut called GLP-1, which signals to the brain when a person is full. All dose sizes of Pfizer's pill showed "statistically significant reductions" in body weight ranging from 6.9% to 11.7% at 32 weeks, and from 4.8% to 9.4% at 26 weeks. Meanwhile, patients on a placebo lost 8% to 13% of their body weight at 32 weeks and 5% to 9.5% at 26 weeks, Pfizer said. The company said high rates of adverse events were observed among patients in the study, with up to 73% experiencing nausea, up to 47% vomiting and up to 25% experiencing diarrhea. More than 50% of patients across all dose sizes stopped taking the pill, compared to roughly 40% among those on the placebo, according to Pfizer. No new safety issues were observed, and danuglipron was not associated with increased liver enzymes like Pfizer's other discontinued weight loss pill. All data is taken from the source: http://cnbc.com Article Link: https://www.cnbc.com/2023/12/01/pfizer-to-discontinue-twice-daily-version-of-weight-loss-pill.html #weight #newshour #newstodayheadlines #newstodayfox #newstodayupdate #newstodayworld #

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In a candid interview with Trisha Paytas on the Just Trish podcast, Lizzo shares her weight loss journey, revealing that while she tried Ozempic, it was a change in her diet that truly helped her. Lizzo discusses her transition from a vegan diet to incorporating whole foods like beef, chicken, and fish, which she found more satisfying and filling. She emphasizes that her approach may not work for everyone, as each body is different. Watch the full interview to hear Lizzo's insights on her health journey and the impact of dietary changes.

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