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BMO Capital Markets managing director of biopharma equity research Evan Seigerman joins Market Domination to discuss the best biotech plays outside of the GLP-1 weight-loss space. The sky-high demand for GLP-1 weight-loss drugs has led the biotech sector to reach new heights over the last year, and Seigerman believes the trend is as "hot as ever." He notes that the 2024 European Association for the Study of Diabetes (EASD) meeting revealed key data highlighting the importance of these weight-loss drugs, and he believes that players like Eli Lilly (LLY) and Novo Nordisk (NVO) continue to lead the industry's growth. However, he sees opportunities outside of the GLP-1 landscape, pointing specifically to Regeneron (REGN) and Vertex (VRTX) as prime examples. Vertex, a leader in cystic fibrosis research, makes up about $10 billion of its core franchise. The company is on track for early 2025 approval of its next-generation cystic fibrosis treatment as well as a non-opioid, non-addictive pain medication. In addition, Vertex has partnered with CRISPR Therapeutics (CRSP) and received approval for Casgevy, a cell therapy treatment for sickle cell disease and beta-thalassemia. Seigerman notes that the uptake has been slow as it requires patients to be in the hospital for at least a month as they go through the process. However, he explains that the therapy works and is "really transformational" for patients. While Seigerman is bullish on Vertex, he notes that the stock's price is rather high, trading in the upper $400s. The other risk he highlights is a non-opioid paid medication competitor coming to market. #youtube #stockmarket #news About Yahoo Finance: Yahoo Finance provides free stock ticker data, up-to-date news, portfolio management resources, comprehensive market data, advanced tools, and more information to help you manage your financial life. - Get the latest news and data at finance.yahoo.com - Download the Yahoo Finance app on Apple (https://apple.co/3Rten0R) or Android (https://bit.ly/3t8UnXO) - Follow Yahoo Finance on social: X: http://twitter.com/YahooFinance Instagram: https://www.instagram.com/yahoofinance/?hl=en TikTok: https://www.tiktok.com/@yahoofinance?lang=en Facebook: https://www.facebook.com/yahoofinance/ LinkedIn: https://www.linkedin.com/company/yahoo-finance
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As a mild mitochondrial poison, metformin carries a variety of downsides. Taking it may have about a 1-in-67,000 chance of killing you every year. This is the fourth video in a five-part series. If you missed any so far, see: • Naturally Boosting AMPK with Caloric Restriction for Life Extension (https://nutritionfacts.org/video/naturally-boosting-ampk-with-caloric-restriction-for-life-extension) • Naturally Boosting AMPK with Exercise for Life Extension (https://nutritionfacts.org/video/naturally-boosting-ampk-with-exercise-for-life-extension) • Does Metformin Work as a Life-Extension Drug? (https://nutritionfacts.org/video/does-metformin-work-as-a-life-extension-drug ) And stay tuned for The TAME Trial: Targeting Aging with Metformin (https://nutritionfacts.org/video/the-tame-trial-targeting-aging-with-metformin). AMPK is one of the anti-aging pathways I highlight in my longevity book, How Not to Age (https://nutritionfacts.org/book/how-not-to-age/), available in print, e-book, and audio. (All proceeds I receive from the book are donated directly to charity.) New subscribers to our e-newsletter always receive a free gift. Get yours here: https://nutritionfacts.org/subscribe/. Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/side-effects-of-metformin-as-a-life-extension-drug and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at https://nutritionfacts.org/video/side-effects-of-metformin-as-a-life-extension-drug. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages; you can find yours in the video settings. View important information about our translated resources: https://nutritionfacts.org/translations-info/ https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Books: https://nutritionfacts.org/books • Shop: https://drgreger.org • Facebook: https://www.facebook.com/NutritionFacts.org • Twitter: https://twitter.com/nutrition_facts • Instagram: https://www.instagram.com/nutrition_facts_org
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