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Gear, Growth, and Gains Ep. 014 Peptide Reconstitution Demystified, Emerging Data on Combined GLP-1 Agonists and Myostatin Inhibitors, Oral Steroids and the Heart, and Coach's Corner - Training Volume Myths Show Time 32 min, 26 sec Show Notes and Description In episode 14 of "Gear Growth and Gains," Type-IIx discusses evidence-based practices in enhanced bodybuilding. He debunks myths about peptide reconstitution, emphasizing normal saline as the optimal solvent. The episode reviews emerging clinical data on combining GLP-1 agonists with myostatin inhibitors for improved muscle retention during weight loss. Type-IIx explains why oral 17 alpha-alkylated steroids pose greater cardiovascular risks than injectables due to their effects on lipid metabolism. Finally, he clarifies that excessive training volume impairs hypertrophy, stressing the importance of quality, intensity, and recovery for muscle growth. Outline and Timestamps Introduction and Episode Overview (00:00:30) Type-IIx introduces the podcast, outlines the four main topics, and provides disclaimers and promotional info. Peptide Reconstitution: Myths and Best Practices (00:02:56) Explains misconceptions about peptide reconstitution, debunks bro science, and emphasizes normal saline as the best solvent. History of Bro Science in Peptide Use (00:04:07) Describes the origins of peptide reconstitution myths in early bodybuilding forums and how misinformation spread. NAD+ and Solvent Confusion (00:06:33) Discusses the rise of NAD+ injections, their ineffectiveness, and confusion about which solvents to use. Normal Saline vs. Bacteriostatic Water (00:08:02) Clarifies why normal saline is preferred for reconstitution, and addresses misconceptions about bacteriostatic water. Properties and Safety of Normal Saline (00:09:05) Explains what normal saline is, its isotonic properties, and why it’s safe and widely used. Risks of Bacteriostatic Water and Solvent Regulation (00:10:24) Compares the risks of homemade bacteriostatic water to normal saline and explains regulatory reasons. GLP-1 Agonists and Myostatin Inhibitors: New Data (00:11:32) Introduces the COURAGE trial and the rationale for combining GLP-1 agonists with trevogrumab. Strategies to Preserve Muscle on GLP-1 Drugs (00:12:38) Outlines three strategies to maintain muscle while using GLP-1 drugs, focusing on drug interventions. Myostatin Inhibitors: Mechanisms and Trials (00:13:48) Reviews the history, mechanisms, and clinical trials of myostatin inhibitors, including new combination therapies with trevogrumab. COURAGE Trial Results and Drug Synergy (00:14:59) Details the COURAGE trial’s experimental groups, results, and the synergy of combining the myostatin inhibitor trevogrumab with GLP-1 drugs. Molecular Pathways in Muscle Growth (00:15:59) Explains the molecular signaling pathways involved in muscle growth and how different drugs interact. Safety and Side Effects of Myostatin/Activin-A Inhibitors (00:16:14) Discusses the safety profile of new myostatin inhibitors like trevogrumab and the side effects of anti-activin A drugs. Oral Steroids and Cardiovascular Risk (00:17:31) Explains why 17 alpha-alkylated oral steroids like Anavar are more harmful to heart health than injectables. Mechanisms of Steroid-Induced Dyslipidemia (00:18:47) Describes how oral steroids negatively affect lipid profiles and increase cardiovascular risk. Estrogen’s Protective Role and Specific Steroid Effects (00:20:08) Covers the protective effects of estrogen on lipids and why certain steroids are harsher on the heart. Summary: Why Some Steroids Are Safer for Lipids (00:21:20) Summarizes why Dianabol is less harsh on lipids and why Trenbolone is still risky despite being injectable. Book Promotion: Bolus Guide (00:21:20) Promotes the Bolus guide for practical bodybuilding drug protocols and research interpretation. Bloodwork and Lab Testing Recommendations (00:23:07) Recommends Fitomics for blood work and explains how to sign up for lab testing and newsletters. Coach’s Corner: Training Volume Myths (00:24:10) Explains why more sets, reps, or sessions are not better for muscle growth and can be counterproductive. Mechanisms of Hypertrophy and Recovery (00:25:25) Discusses the science of muscle growth, the importance of recovery, and the difference between strength and size. Effective Reps and Optimal Training Volume (00:26:35) Emphasizes the importance of effective reps, diminishing returns of excessive volume, and the inverse dose-response curve. Conclusion and Outro (00:26:35) Wraps up the episode and promises more regular content in the future. Topics Gear Growth and Gains, Meso-Rx, enhanced bodybuilding, peptide reconstitution, peptides, broscience, normal saline, GLP-1, trevogrumab, GLP-1 agonists, myostatin inhibitors, Courage trial, semaglutide, muscle retention, fat loss, oral steroids, cardiovascular risk, 17 alpha-alkylated steroid...

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The use of GLP-1 Agonists has become a divisive topic in the fitness industry. In this episode of The Fitness Rants Podcast, we share our POV. We offer a simplified explaination of what GLP 1 Agonists are, how they work, and what they were initially developed for. Then we explore the reasons why they their use has created such a divide amongst coaches. We round out the podcast with our stance and how GLP-1 agonists could be applied meaningfully in practice. 🎙️ The episode will be live at noon, Friday, 25th July. For the audio version, subscribe on Apple Podcasts or Spotify: Apple Podcast: https://podcasts.apple.com/ae/podcast/the-fitness-rants-podcast/id1827967641 Spotify: https://open.spotify.com/show/4pVKhwRc2b3zYSN93v3s1g?si=qtIbpKcmSgaWafHjyNmjlw Connect with us on Instagram for Episode shorts and sneak peeks: https://www.instagram.com/fitnessrantspod/ Connect With Your Hosts: Ross - https://www.instagram.com/thephysiquecoach_/ Mal - https://www.instagram.com/thestrengthcurvecoach/

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Lizzo just shook the internet with her stunning weight transformation—rocking a hot pink Yitty set and embracing self-love like never before. Since 2023, she’s focused on mental health, self-acceptance, and body neutrality—not trends or quick fixes. No Ozempic. No shortcuts. Just consistent work, balance, and confidence. This is more than a glow-up—it’s a wellness revolution. #Lizzo #WeightLossJourney #BodyPositivity #Yitty #SelfLove #HealthOverHype #NoOzempic #BodyNeutrality #LizzoTransformation #WomensEmpowerment #ViralShorts

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North Carolina's state health plan will deny coverage of some GLP-1 weight loss drugs, including Novo Nordisk's (NVO) Wegovy and Ozempic, and Eli Lilly's (LLY) Mounjaro. The state claims the drugs are too expensive to cover. University of Pennsylvania Vice Provost for Global Initiatives Dr. Ezekiel Emanuel joins Yahoo Finance' Julie Hyman and Josh Lipton to discuss why he feels the drugs are cost-effective for certain patients, and offers strategies for the state to pay for the coverage. Emanuel explains how North Carolina State health officials advanced a limited view of cost-effectiveness: "If you look at the cost-effectiveness analyses of these drugs for patients who have obesity, they're cost effective. They, in fact, meet [the executive director of the health plan's] criteria, and they do a lot of good for patients who have obesity. Not only do they reduce weight, they also reduce their risk of cardiovascular disease by 20% in the first year. So, they meet his standard of cost-effectiveness. He did not actually do the calculations and examine whether they're cost-effective or not." #youtube #weightloss #yahoofinance About Yahoo Finance: Yahoo Finance provides free stock ticker data, up-to-date news, portfolio management resources, comprehensive market data, advanced tools, and more information to help you manage your financial life. - Get the latest news and data at finance.yahoo.com - Download the Yahoo Finance app on Apple (https://apple.co/3Rten0R) or Android (https://bit.ly/3t8UnXO) - Follow Yahoo Finance on social: X: http://twitter.com/YahooFinance Instagram: https://www.instagram.com/yahoofinance/?hl=en TikTok: https://www.tiktok.com/@yahoofinance?lang=en Facebook: https://www.facebook.com/yahoofinance/ LinkedIn: https://www.linkedin.com/company/yahoo-finance

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GET YOUR 8 FREE SERVINGS OF LMNT!! (You just pay for shipping!)👇🏻 https://www.DrinkLMNT.com/Autumn Thanks LMNT for sponsoring today's video! The BEST Fat Burning Walking For Weight Loss Schedule When you’re looking to create a walking for weight loss schedule, there are three times of day to consider. Your morning walk, your day time walk and your evening walk. Each of these walking times has different goals and purposes to help you achieve your weight loss goals with walking. Today, I’m sharing the BEST fat burning walking for weight loss schedule, taking all of these factors into consideration. THE STEP TRACKER I USE (contains affiliate link): https://amzn.to/3ltfXyB COMPLETE INTERMITTENT FASTING PROGRAM: https://www.autumnellenutrition.com/product-page/the-complete-intermittent-fasting-bundle SUBSCRIBE + JOIN THE AENPEEPS! https://www.youtube.com/c/autumnbates?sub_confirmation=1 *STAY CONNECTED* ~FREE WEEKLY NUTRITION NEWSLETTER: https://www.autumnellenutrition.com/subscribe ~BINGE THE BLOG: https://www.autumnellenutrition.com/blog ~INSTAGRAM: https://www.instagram.com/autumnelle_nutrition/ ~PINTEREST: https://www.pinterest.com/autumnellenutrition/ ~AUTUMN ELLE NUTRITION FACEBOOK GROUP: https://www.facebook.com/groups/495358827589380/?multi_permalinks=655889568202971¬if_id=1551908008215594¬if_t=group_activity NOTE: This description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is in NO WAY obligated to use these links. Thank you for your support! Disclaimer: This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a nutritionist-client relationship between Autumn Bates and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis and recommendation. Always seek the advice of a physician, Nutritionist or other qualified health provider with any questions you may have regarding a medical condition. Autumn Elle Nutrition Inc. is not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or site.

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Shop the best of Shark Tank products now: https://tinyurl.com/SharkTankShopin Click here to subscribe: https://www.youtube.com/c/sharktankindia 'Anuvad' is an innovative e-textile brand founded by Chhail Khalsa from Ahmedabad. The company specializes in creating textiles integrated with technology, such as musical fabrics crafted by Indian artisans. 'Fitelo' is a wellness platform dedicated to redefining weight loss through natural and sustainable methods. 'Nanighar' is an innovative platform founded by Mukherjee, an accomplished marketing professional and mother of three, the platform aims to empower homemakers by transforming them into home chefs, allowing them to showcase their culinary talents and earn income. Will the sharks be interested in investing? Watch the pitch to find out! For more exciting content: https://tinyurl.com/SharkTankIndiaS04 Stay tuned for the latest updates of Shark Tank India Season 4. #sharktankindiaseason4 #SharkTankIndia Follow us on: Instagram: https://www.instagram.com/sonypicturestvindia/ Facebook: https://www.facebook.com/SonyPicturesTelevisionIndia #sharktankindiaseason4 #startup #businesstvshow #funding #investment #indiansharktank #sharks #entrepreneur #idea #money #profit #loss #namitathapar #vineetasingh #peyushbansal #anupammittal #amangupta #kunalbahl #varundua #azhariqubal #investmentstrategies #buildingbrands #startupsuccess #sharksinaction #season4pitches #innovativeideas #futureofbusiness #dreambig #investmentinindia #bestpitches #newseason #nanighar #food #homecooked #womenledbusiness #supportwomen #localflavours #foodstartup #smartweightloss #healthyliving #wellnessrevolution #wellnessapp #nutritionmadeeasy #mindfuleating #fitnessgoal#anuvad #futureoffashion #smartclothing #handcraftedttech #textileinnovation #musicalfabrics #wearabletech #indianhandicrafts #madeinindia #sustainablefashion Shark Tank India S4 | Ep 43 | इन musical notes को सुनकर Sharks का मन हुआ calm | Full Episode

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NO SUGAR STRAWBERRY SMOOTHIE POWER BOWL - GLUTEN-FREE & VEGAN - https://meghnasfoodmagic.in/recipe/strawberry-smoothie-bowl/ Post workout do you feel hungry & crave for food to fill up the stomach ? Try this 3 ingredient Strawberry Smoothie bowl! 🍓🥣 This gluten-free and vegan treat is the perfect guilt-free indulgence. Packed with vitamins, nutrients, and antioxidants, it’s not only delicious but also great for you! Whether you’re looking for a quick breakfast or a refreshing afternoon snack, our Strawberry Smoothie bowl is the way to go. Ingredients : 10-12 strawberries 5-6 dates 4 tbs soaked oats And some water Method: - In a mixer grinder, take strawberries, dates, soaked oats, and some water - Blend it nicely - You can customize it with your favorite toppings like granola, chia seeds, or fresh fruit to make it your own It’s the perfect way to satisfy your sweet tooth while staying on track with your health goals. And the best part? You can customize it with your favorite toppings like granola, chia seeds, or fresh fruit to make it your own. So go ahead, give it a try and let us know what you think! Don’t forget to tag me in your stories - photos or video- for a chance to be featured on our stories. Enjoy! . [ No Sugar Strawberry Smoothie , Smoothie Power Bowl Recipe , Vegan Strawberry Bowl , Gluten-Free Smoothie Bowl , Healthy Strawberry Recipes , No Added Sugar Smoothie , Plant-Based Power Bowl , Natural Sweeteners in Smoothies , Easy Vegan Recipes , High Fiber Smoothie , Strawberry and Date Smoothie , Breakfast Smoothie Bowl , Dairy-Free Vegan Bowl , Antioxidant Smoothie Recipe , Low-Calorie Smoothies , Homemade Smoothie Bowl , Nutrient-Dense Breakfast Options , Organic Strawberry Snacks , No Sugar Added Recipes , Healthy Meal Prep Ideas ] . Love M #ChefMeghna #StrawberrySmoothieBowl #Healthyeats #VeganTreats 🍓🌱 #healthyEating #veganeats #GlutenFreeLiving #SmoothieBowl #HealthyTreats #PlantBased #Nutrition #StrawberryLove #healthyliving #EatWellLiveWell #Strawberry #smoothies #healthyEating #HealthyLifestyle #PostWorkoutMeal #ReelitFeelIt #FeelitReelit #ReelKaroFeelKaro #FeelKaroReelKaro #weightloss #nosugar #vegan #easypeasy #easypeasyrecipes #GetFitWithMeghna #SeasonsFreshWithMeghna